1.
Bioorg Med Chem Lett
; 11(16): 2133-6, 2001 Aug 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11514154
RESUMO
The design, synthesis, and use of lerisetron-based molecular probes to investigate the 5-HT(3)R binding site are described. A SAR study, which involved distance and electronic parameter modifications of lerisetron's N-benzyl group, resulted in the discovery of a partial agonist.