RESUMO
A series of N,N'-polyalkylenebis[4-(substituted-amino)pyridines] has been prepared, and members have been evaluated as potential anti-dental plaque agents. From among the most active members of the series, one compound, N,N'-[1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene]bis(1-octanam ine) dihydrochloride, octenidine, was selected as a candidate for clinical study.
Assuntos
Aminopiridinas/uso terapêutico , Placa Dentária/tratamento farmacológico , Humanos , Relação Estrutura-AtividadeRESUMO
Investigations were undertaken to evaluate nonresorbable, particulate ceramic hydroxylapatite (durapatite) for augmentation of deficient alveolar ridges. One hundred and fifteen augmentations in both jaws were reported for 110 patients over a 33-month postoperative period. Subjective and objective data show that the implant was successful for all classes of ridges augmented; height, bulk, contour, and ridge form generally improved, and soft tissue overlying the augmented ridges was firm and immobile. Impressions for dentures were usually obtained four to six weeks after surgery, and the dentures were more stable, retentive, and esthetically pleasing than the preoperative prostheses and required fewer relinings. Other than transiently altered sensations resulting from mental nerve manipulation during surgery, patients had few complications. No infection or bone resorption beneath the implant was observed throughout these studies. It was concluded that hydroxylapatite particles placed through a subperiosteal tunnel offer a highly successful method of ridge augmentation and eliminate the most serious problems associated with the use of autogenous or banked bone, namely, morbidity, risk, costliness, and poor results.
Assuntos
Aumento do Rebordo Alveolar/métodos , Alveoloplastia/métodos , Hidroxiapatitas , Procedimentos Cirúrgicos Pré-Protéticos Bucais/métodos , Próteses e Implantes , Adulto , Idoso , Transplante Ósseo , Retenção de Dentadura , Durapatita , Feminino , Humanos , Masculino , Mandíbula/anatomia & histologia , Pessoa de Meia-Idade , Complicações Pós-OperatóriasAssuntos
Processo Alveolar/diagnóstico por imagem , Aumento do Rebordo Alveolar , Mandíbula/cirurgia , Procedimentos Cirúrgicos Pré-Protéticos Bucais , Processo Alveolar/anatomia & histologia , Alveoloplastia , Durapatita , Humanos , Hidroxiapatitas , Mandíbula/anatomia & histologia , Mandíbula/diagnóstico por imagem , Boca Edêntula/cirurgia , Próteses e Implantes , Radiografia PanorâmicaAssuntos
Terapia Comportamental , Hipnose , Hábito de Roer Unhas/terapia , Adulto , Doença Crônica , Feminino , Humanos , Masculino , Hábito de Roer Unhas/psicologiaRESUMO
A new polycrystalline form of hydroxylapatite, CHA, has been shown to closely mimic dental enamel, in vitro, in regard to rate and degree of plaque formation and effectiveness of antiplaque drugs. The material has successfully been exploited as a standardized hydroxylapatite plaque growth substrate in conjuntion with a mass antidental plaque drug screening program.
