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1.
Gut Liver ; 9(3): 381-7, 2015 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-25071069

RESUMO

BACKGROUND/AIMS: Microscopic colitis is characterized by chronic watery diarrhea with specific pathological changes that can be diagnosed by microscopic examination. We performed immunohistochemical analysis of proinflammatory cytokines to investigate the pathogenic mechanism of microscopic colitis. METHODS: This study consisted of six patients with lymphocytic colitis, six patients with collagenous colitis, and six patients with functional diarrhea but normal pathology. We performed an immunohistochemical analysis of the colonic mucosal biopsies to assess the expression of cyclo-oxygenase-2, interleukin-17, nuclear factor-κB, interferon-γ, inducible nitric oxide synthase, and tumor necrosis factor-α. We compared the quantity score of immunohistochemical staining among the groups. RESULTS: The microscopic colitis group showed significantly higher expression of cyclo-oxygenase-2, interleukin-17, nuclear factor-κB, and interferon-γ compared with the control group. Cytokine expression was similar between collagenous colitis and lymphocytic colitis. However, the expression of cyclo-oxygenase-2 was higher in collagenous colitis. CONCLUSIONS: Proinflammatory cytokines, including interleukin-17 and interferon-γ, are highly expressed in microscopic colitis. The expression of cyclo-oxygenase-2 was higher in collagenous colitis than in lymphocytic colitis. This study is the first on interleukin-17 expression in microscopic colitis patients.


Assuntos
Colite Microscópica/metabolismo , Ciclo-Oxigenase 2/metabolismo , Interleucina-17/metabolismo , Óxido Nítrico Sintase Tipo II/metabolismo , Biópsia , Colo/patologia , Citocinas/metabolismo , Diarreia/metabolismo , Humanos , Interferon gama/metabolismo , Mucosa Intestinal/patologia , NF-kappa B/metabolismo , Fator de Necrose Tumoral alfa/metabolismo
2.
Intest Res ; 12(1): 66-9, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25349566

RESUMO

Crohn's disease (CD) may involve any part of the gastrointestinal tract, from the mouth to the anus. Approximately >90% of cases occur in the small bowel and colon. Upper gastrointestinal involvement, especially duodenal manifestation, is relatively rare. Therefore, adequate medical treatment for duodenal CD has not yet been established. We report a case of CD with duodenal involvement. A 46-year-old man with Crohn's ileocolitis presented to our hospital with right upper quadrant pain. An endoscopy showed a deep excavated ulcer with deformity at the duodenal bulb, and he was initially treated with azathioprine (1 mg/kg), Pentasa (3.0 g/day), and a proton pump inhibitor for 1 year. However, the deep ulcer did not heal. Therefore, infliximab infusion therapy was initiated, and the duodenal lesion completely resolved on follow-up esophagogastroduodenoscopy. We report a case of duodenal CD that completely resolved following infliximab infusion, with a review of the literature.

3.
Korean J Gastroenterol ; 49(2): 110-3, 2007 Feb.
Artigo em Coreano | MEDLINE | ID: mdl-17322791

RESUMO

Ischemic colitis is one of the most common intestinal ischemic injury in which more than 90% of patient are over 60 year-old. It results from impaired perfusion of blood to the bowel and is rarely caused by vasculitis such as systemic lupus erythematosus, polyarteritis nodosa, and Takayasu's arteritis. Takayasu's arteritis affects the aortic arch, medium-sized and large arteries but rarely involves inferior mesenteric artery. We report a case of Takayasu's arteritis involving inferior mesenteric artery which developed ischemic colitis in a 70 year old female. To the author's knowledge this is the first case report in Korea. A 70 year old woman who had suffered from Takayasu's arteritis for 5 years was admitted for sudden abdominal pain and hematochezia. On sigmoidoscopy, there were multiple segmental longitudinal ulcerations around splenic flexure and diffuse hemorrhagic edematous mucosa from descending colon to sigmoid colon. On abdominal CT angiography, inferior mesenteric artery was not traced. We diagnosed it as ischemic colitis combined with Takayasu's arteritis. After the conservative treatment, abdominal pain and hematochezia disappeared. She was followed up to 2 years without recurrence of symptoms.


Assuntos
Colite Isquêmica/diagnóstico , Arterite de Takayasu/diagnóstico , Dor Abdominal/diagnóstico , Idoso , Colite Isquêmica/etiologia , Colite Isquêmica/patologia , Feminino , Hemorragia Gastrointestinal , Humanos , Imageamento Tridimensional , Sigmoidoscopia , Arterite de Takayasu/complicações , Arterite de Takayasu/patologia , Tomografia Computadorizada Espiral
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