Association of the new visceral adiposity index with coronary artery calcification and arterial stiffness in Korean population.

BACKGROUND AND AIMS: The new visceral adiposity index (NVAI) is an indirect marker of visceral adipose tissue recently developed using a Korean population. Here we examined the association of NVAI with coronary artery calcification and arterial stiffness in asymptomatic Korean patients. METHODS AND RESULTS: We analyzed data from 60,938 asymptomatic Korean adults. Odds ratios and 95% confidence intervals (CIs) for coronary artery calcification score (CACS) > 100 and brachial-ankle pulse wave velocity (baPWV) ≥14 m/s were calculated across NVAI tertiles using multiple logistic regression analysis. Receiver operating characteristic (ROC) and area under the curve (AUC) analyses were used to assess the ability of NVAI to predict moderate to high risk of cardiovascular disease. The prevalence of moderate and high risk of cardiovascular disease increased significantly as the NVAI tertile increased. The odds ratio (95% CI) of the highest NVAI tertile for CACS >100 was 5.840 (5.101-6.686) for men and 18.916 (11.232-31.855) for women, after adjusting for confounders. All NVAI AUC values were significantly higher than the AUC values for other visceral adiposity markers. CONCLUSIONS: This study provides the evidence that NVAI is independently and positively associated with coronary calcification and arterial stiffness in asymptomatic Korean adults.

[2+2] Photocycloaddition of Cinnamates in Flow and Development of a Thiourea Catalyst.

Cyclobutanes derived from the dimerization of cinnamic acids are the core scaffolds of many molecules with potentially interesting biological activities. By utilizing a powerful flow photochemistry platform developed in our laboratory, we have evaluated the effects of flow on the dimerization of a range of cinnamate substrates. During the course of the study we also identified a bis(thiourea) catalyst that facilitates better reactivity and moderate diastereoselectivity in the reaction. Overall, we show that carrying out the reaction in flow in the presence of the catalyst affords consistent formation of predictable cyclobutane diastereomers.

Expression and characterization of an extremely thermostable ß-glycosidase (mannosidase) from the hyperthermophilic archaeon Pyrococcus furiosus DSM3638.

Genomic analysis of the hyperthermophilic archaeon Pyrococcus furiosus revealed the presence of an open reading frame (ORF PF0356) similar to the enzymes in glycoside hydrolase family 1. This ß-glycosidase, designated PFTG (P. furiosus thermostable glycosidase), was cloned and expressed in Escherichia coli. The expressed enzyme was purified by heat treatment and Ni-NTA affinity chromatography. The gene was composed of 1,452 bp encoding 483 amino acids for a protein with a predicted molecular mass of 56,326 Da. The temperature and pH optima were 100°C and 5.0 in sodium citrate buffer, respectively. The substrate specificity of PFTG suggests that it possesses characteristics of both ß-galactosidase and ß-mannosidase activities. However, through kinetic studies by ITC (Isothermal Titration Colorimetry) which is very sensitive method for enzyme kinetics, PF0356 enzyme revealed the highest catalytic efficiency toward p-nitrophenyl-ß-d-mannopyranoside (3.02 k(cat)/K(m)) and mannobiose (4.32 k(cat)/K(m)). The enzyme showed transglycosylation and transgalactosylation activities toward cellobiose, lactose and mannooligosaccharides that could produce GOS (galactooligosaccharides) and MOS (maltooligosaccharides). This novel hyperthermostable ß-glycosidase may be useful for food and pharmaceutical applications.

Adolescents' peer-rated mental health, peer-acceptance, and irrational beliefs.

Based on the notion of positive psychology, the interrelationships among peer-rated mental health, social acceptance and irrational beliefs were examined using Korean youth. We predicted that adolescents who were rated by their peers to be relatively more mentally healthy, compared to those who were rated to be less mentally healthy, would (a) receive higher social acceptance from peers and (b) report fewer irrational beliefs. 476 adolescents (252 boys and 224 girls; M age = 16.7 yr., SD=.46), all recruited from a single high school in an upper middle-class area in Seoul, Korea, rated each others' mental health in five areas of mental health, i.e., concern for others, contentment with life, creativity and industry, good interpersonal relationships and ability to cope with stressful situations and social acceptance and responded to a questionnaire measuring irrational beliefs. Analysis showed that those adolescents who were rated by their peers to be more mentally healthy received higher social acceptance from those peers than those rated as less mentally healthy; however, this effect size was small. Implications of the study are discussed.

Does sex of client affect counselors' evaluation?

This study examined whether clients' positive or negative self-disclosure and sex affected counselors' evaluation of the clients. 80 counselors (30 certified, 45 master's and five doctoral trainees; six men and 74 women), after viewing a video-taped counseling interview in which the client self-disclosed either largely positive or negative contents responded to the Clinical Impression Scale which contained 8 clinical characteristics of clients (assertiveness, overall coping skills, anxiety, attitude toward counseling, motivation to change, self-esteem, insight, and depression). When the client self-disclosed largely negative content about self, counselors evaluated male client more negatively, i.e., less assertive, poor coping skills, higher anxiety, more negative attitude toward counseling, less eager to change, lower self-esteem, less insight, and higher depression) than female client. However, when the client self-disclosed largely positive content, there was no statistically significant sex difference between the two groups. The implications are discussed.

Clients' attributions of recalled important or helpful events in a counseling interview.

Clients' causal explanations for recalled important or helpful events between those of early and of late sessions of counseling interview have been examined. We predicted that (a) for clients' recalled important or helpful events, there will be more internal attribution in late than in early sessions and (b) clients' evaluation of counseling sessions would be positively related to their internal attribution of the recalled important or helpful events. Data were generated from 84 sessions of therapy, with 12 counselor-client dyads conducting seven sessions of therapeutic interviews each. Immediately after each interview, clients were requested to recall and explain the most important or helpful events that happened during the session. Clients' causal explanations of the events were analyzed by two trained judges. Results showed no statistically significant differences in frequencies of internal attribution. Similarly, internal attribution did not covary with clients' evaluation of counseling sessions. The implications of the results are discussed.

Opacification of a hydrophilic acrylic intraocular lens with exacerbation of Behçet's uveitis.

Behçet's disease is 1 of the most common causes of uveitis in the Eastern world. Its common ocular complications are uveitis, cataract, and obliteration of retinal vessels. Phacoemulsification with intraocular lens (IOL) implantation in patients with Behçet's disease is known to be a safe procedure. We managed a patient with Behçet's disease who had aggravated uveitis and opacification of a hydrophilic acrylic IOL (ACRL-C160, Ophthalmed) 4 months after cataract surgery. Recalcitrant uveitis despite maximum tolerable medication and IOL opacification with vitreous opacity necessitated an IOL exchange and trans pars plana vitrectomy. After the procedure, the eye became quiescent. However, the visual acuity was 20/200 because of the obliteration of retinal vessels.