A practical approach for finding anti-debugging routines in the Arm-Linux using hardware tracing.

As IoT devices are being widely used, malicious code is increasingly appearing in Linux environments. Sophisticated Linux malware employs various evasive techniques to deter analysis. The embedded trace microcell (ETM) supported by modern Arm CPUs is a suitable hardware tracer for analyzing evasive malware because it is almost artifact-free and has negligible overhead. In this paper, we present an efficient method to automatically find debugger-detection routines using the ETM hardware tracer. The proposed scheme reconstructs the execution flow of the compiled binary code from ETM trace data. In addition, it automatically identifies and patches the debugger-detection routine by comparing two traces (with and without the debugger). The proposed method was implemented using the Ghidra plug-in program, which is one of the most widely used disassemblers. To verify its effectiveness, 15 debugger-detection techniques were investigated in the Arm-Linux environment to determine whether they could be detected. We also confirmed that our implementation works successfully for the popular malicious Mirai malware in Linux. Experiments were further conducted on 423 malware samples collected from the Internet, demonstrating that our implementation works well for real malware samples.

iSCNT embryo culture system for restoration of Cervus nippon hortulorum, presumed to be sika deer in the Korean Peninsula.

Sika deer inhabiting South Korea became extinct when the last individual was captured on Jeju Island in Korea in 1920 owing to the Japanese seawater relief business, but it is believed that the same subspecies (Cervus nippon hortulorum) inhabits North Korea and the Russian Primorskaya state. In our study, mt-DNA was used to analyze the genetic resources of sika deer in the vicinity of the Korean Peninsula to restore the extinct species of continental deer on the Korean Peninsula. In addition, iSCNT was performed using cells to analyze the potential for restoration of extinct species. The somatic cells of sika deer came from tissues of individuals presumed to be Korean Peninsula sika deer inhabiting the neighboring areas of the Primorskaya state and North Korea. After sequencing 5 deer samples through mt-DNA isolation and PCR, BLAST analysis showed high matching rates for Cervus nippon hortulorum. This shows that the sika deer found near the Russian Primorsky Territory, inhabiting the region adjacent to the Korean Peninsula, can be classified as a subspecies of Cervus nippon hortulorum. The method for producing cloned embryos for species restoration confirmed that iSCNT-embryos developed smoothly when using porcine oocytes. In addition, the stimulation of endometrial cells and progesterone in the IVC system expanded the blastocyst cavity and enabled stable development of energy metabolism and morphological changes in the blastocyst. Our results confirmed that the individual presumed to be a continental deer in the Korean Peninsula had the same genotype as Cervus nippon hortulorum, and securing the individual's cell-line could restore the species through replication and produce a stable iSCNT embryo.

UnSafengine64: A Safengine Unpacker for 64-Bit Windows Environments and Detailed Analysis Results on Safengine 2.4.0.

Despite recent remarkable advances in binary code analysis, malware developers still use complex anti-reversing techniques that make analysis difficult. Packers are used to protect malware, which are (commercial) tools that contain diverse anti-reversing techniques, including code encryption, anti-debugging, and code virtualization. In this study, we present UnSafengine64: a Safengine unpacker for 64-bit Windows. UnSafengine64 can correctly unpack packed executables using Safengine, which is considered one of the most complex commercial packers in Windows environments; to the best of our knowledge, there have been no published analysis results. UnSafengine64 was developed as a plug-in for Pin, which is one of the most widely used dynamic analysis tools for Microsoft Windows. In addition, we utilized Detect It Easy (DIE), IDA Pro, x64Dbg, and x64Unpack as auxiliary tools for deep analysis. Using UnSafengine64, we can analyze obfuscated calls for major application programming interface (API) functions or conduct fine-grained analyses at the instruction level. Furthermore, UnSafengine64 detects anti-debugging code chunks, captures a memory dump of the target process, and unpacks packed files. To verify the effectiveness of our scheme, experiments were conducted using Safengine 2.4.0. The experimental results show that UnSafengine64 correctly executes packed executable files and successfully produces an unpacked version. Based on this, we provided detailed analysis results for the obfuscated executable file generated using Safengine 2.4.0.

Habitat suitability and connectivity modeling predict genetic population structure and priority control areas for invasive nutria (Myocastor coypus) in a temperate river basin.

The nutria (Myocastor coypus), also known as the coypu, is a semi-aquatic, invasive rodent native to South America that causes damage to natural riverine and wetland habitats in many parts of the world, including South Korea. Understanding habitat use, connectivity, and gene flow of nutria populations is critical for the sound management of local and regional ecosystems. Here, we assessed habitat suitability and connectivity in relation to the genetic structure of nutria populations in the Nakdong River Basin of South Korea. A total of 321 nutria occurrence sites and seven environmental variables were used to perform ensemble habitat suitability modeling using five species distribution models (SDMs), including boosted regression trees, maximum entropy model, random forest, generalized linear model, and multivariate adaptive regression splines. Using graph and circuit theory approaches, we assessed the population gene flow and current flow betweenness centrality (CFBC) of suitable habitats derived from the ensemble SDM. All SDMs performed well with a range of test AUC values from 0.962 to 0.970 (mean = 0.966) with true skill statistic values over 0.8. The minimum temperature of the coldest month, mean temperature of the warmest quarter, precipitation of the driest quarter, and distance from water bodies were important predictors in nutria habitat modeling. Nutria population gene flow was significantly correlated with the least-cost path distance on a cost resistance surface based on ensemble habitat suitability modeling and roads (Mantel's r = 0.60, p < 0.05). Finally, the CFBC positively correlated with the genetic diversity of nutria populations was used to identify priority control areas. Habitat suitability and connectivity modeling not only revealed environmental conditions and areas that support the survival and spread of nutrias, but also improved our understanding of the animals' genetic population structure, thereby indicating priority areas to target for eradication.

Porcine endometrial 3D co-culture: Morphological changes in 3D endometrium tissues according to hormonal changes.

Cells cultured as monolayers proliferate well, but do not sustain their differentiation characteristics. Previous studies have investigated the interactions between cells and growth factors or cytokines by establishing either in vivo or in vitro three-dimensional (3D) cultures. Using porcine uterine epithelial cells and endometrial cells, the current study was designed to develop a 3D uterine culture system and investigate the response to hormone treatment. Formation of the 3D uterine model was similar to that of uterus from the group supplemented with calcium and magnesium, and the addition of these ions altered the spectrum of basement membrane degrading enzyme expression and activity. In particular, the epithelial cell junctions in the 3D model most closely resembled those of an actual uterus when the medium was supplemented with calcium and magnesium; the intercellular basement membrane structure was also tall under these conditions. The study confirmed that Casp-3 expression was lowest in the P4 (progesterone) treatment group, and this hormone was the most potent stimulus for formation of the endometrial cell layer. Therefore, the addition of calcium and magnesium plays an important role in the formation of a 3D uterine model, and the addition of P4 hormone mimics uterine thickening by stimulating growth of the epithelial cell layer.

The complete chloroplast genome of a moss Korea Climacium dendroides (Hedw.) F. Weber & D. Mohr.

The complete chloroplast (cp) genome sequence of Climacium dendroides, determined using Illumina sequencing data, is presented herein. The DNA sequence of C. dendroides is 124,957 bp in length and has an overall CG content of 29.0%, including 82 protein-coding genes, 36 transfer RNA genes, and 8 ribosomal RNA genes. Phylogenetic trees were constructed based on the cp genome sequences of 10 bryophytes downloaded from GenBank and one acquired from this study.

DDR-coin: An Efficient Probabilistic Distributed Trigger Counting Algorithm.

A distributed trigger counting (DTC) problem is to detect w triggers in the distributed system consisting of n nodes. DTC algorithms can be used for monitoring systems using sensors to detect a significant global change. When designing an efficient DTC algorithm, the following goals should be considered; minimizing the whole number of exchanged messages used for counting triggers and even distribution of communication loads among nodes. In this paper, we present an efficient DTC algorithm, DDR-coin (Deterministic Detection of Randomly generated coins). The message complexity-the total number of exchanged messages-of DDR-coin is O(nlogn(w/n)) in average. MaxRcvLoad-the maximum number of received messages to detect w triggers in each node-is O(logn(w/n)) on average. DDR-coin is not an exact algorithm; even though w triggers are received by the n nodes, it can fail to raise an alarm with a negligible probability. However, DDR-coin is more efficient than exact DTC algorithms on average and the gap between those is increased for larger n. We implemented the prototype of the proposed scheme using NetLogo 6.1.1. We confirmed that experimental results are close to our mathematical analysis. Compared with the previous schemes-TreeFill, CoinRand, and RingRand- DDR-coin shows smaller message complexity and MaxRcvLoad.

Genetic diversity and genetic structure of the Siberian roe deer (Capreolus pygargus) populations from Asia.

BACKGROUND: The roe deer, Capreolus sp., is one of the most widespread meso-mammals of Palearctic distribution, and includes two species, the European roe deer, C. capreolus inhabiting mainly Europe, and the Siberian roe deer, C. pygargus, distributed throughout continental Asia. Although there are a number of genetic studies concerning European roe deer, the Siberian roe deer has been studied less, and none of these studies use microsatellite markers. Natural processes have led to genetic structuring in wild populations. To understand how these factors have affected genetic structure and connectivity of Siberian roe deer, we investigated variability at 12 microsatellite loci for Siberian roe deer from ten localities in Asia. RESULTS: Moderate levels of genetic diversity (H(E) = 0.522 to 0.628) were found in all populations except in Jeju Island, South Korea, where the diversity was lowest (H(E) = 0.386). Western populations showed relatively low genetic diversity and higher degrees of genetic differentiation compared with eastern populations (mean Ar = 3.54 (east), 2.81 (west), mean F(ST) = 0.122). Bayesian-based clustering analysis revealed the existence of three genetically distinct groups (clusters) for Siberian roe deer, which comprise of the Southeastern group (Mainland Korea, Russian Far East, Trans-Baikal region and Northern part of Mongolia), Northwestern group (Western Siberia and Ural in Russia) and Jeju Island population. Genetic analyses including AMOVA (F(RT) = 0.200), Barrier and PCA also supported genetic differentiation among regions separated primarily by major mountain ridges, suggesting that mountains played a role in the genetic differentiation of Siberian roe deer. On the other hand, genetic evidence also suggests an ongoing migration that may facilitate genetic admixture at the border areas between two groups. CONCLUSIONS: Our results reveal an apparent pattern of genetic differentiation among populations inhabiting Asia, showing moderate levels of genetic diversity with an east-west gradient. The results suggest at least three distinct management units of roe deer in continental Asia, although genetic admixture is evident in some border areas. The insights obtained from this study shed light on management of Siberian roe deer in Asia and may be applied in conservation of local populations of Siberian roe deer.

Fully roll-to-roll gravure printable wireless (13.56 MHz) sensor-signage tags for smart packaging.

Integration of sensing capabilities with an interactive signage through wireless communication is enabling the development of smart packaging wherein wireless (13.56 MHz) power transmission is used to interlock the smart packaging with a wireless (13.56 MHz) reader or a smart phone. Assembly of the necessary componentry for smart packaging on plastic or paper foils is limited by the manufacturing costs involved with Si based technologies. Here, the issue of manufacturing cost for smart packaging has been obviated by materials that allow R2R (roll-to-roll) gravure in combination with R2R coating processes to be employed. R2R gravure was used to print the wireless power transmission device, called rectenna (antenna, diode and capacitor), and humidity sensor on poly(ethylene terephtalate) (PET) films while electrochromic signage units were fabricated by R2R coating. The signage units were laminated with the R2R gravure printed rectenna and sensor to complete the prototype smart packaging.

The role of temporalis fascia for free mucosal graft survival in small nasal septal perforation repair.

Temporalis fascia has been used widely as a interposition graft for mucosal rotation flap in nasal septal perforation repair. However, the exact role of temporalis fascia in healing process has not yet been clarified. For the pedicle of rotation flap has been considered as a major vehicle for nutrition distribution, the role of temporalis fascia has been devaluated. In this study, we experienced small nasal septal perforation repairs using free mucosal graft not having pedicles but covered by temporalis fascia. Three patients with small nasal septal perforations not larger than 1 × 1 cm were included. In 2 patients, the perforations were repaired using free composite grafts from the inferior turbinate mucosa covered by continuous temporalis fascia not divided, and the surgical results were successful with complete healings. In 1 patient, however, the temporalis fascia was divided into 2 parts to better fit the shape of the perforation, and the graft failed to survive. These surgical results suggest that the temporalis fascia might have an important role in healing process of nasal septal defect and could be used as a beneficial options for small mucosal defect repair surgeries using free mucosal grafts.

Mitochondrial genetic diversity, phylogeny and population structure of Hydropotes inermis in South Korea.

The water deer (Hydropotes inermis) is one of the rarest species of deer in the family Cervidae. Only two subspecies exist in East Asia, and few studies have examined the genetic characteristics of the species. Here, we investigated the genetic diversity, phylogeny and population differentiation of the Korean subspecies (H. inermis argyropus). Seventeen mitochondrial D-loop haplotypes (822 bp) were detected and analyzed from 107 individual samples, together with a Chinese subspecies (H. inermis inermis) haplotype. The genetic diversity of the Korean subspecies is lower (π = 0.756%, h = 0.867) than that of the Chinese subspecies estimated in a previous study. This low genetic diversity may result from historical anthropogenic disturbances and/or a founder effect during the glacial period. The phylogenetic tree and median-joining network showed no location-specific distribution of D-loop haplotypes, but revealed two major lineages, A and B, of water deer. The A and B lineages were separated from each other at the beginning of the Pleistocene era (2.1-1.3 million years ago), with a genetic divergence of 1.332 ± 0.340%. The genetic divergence within lineages A and B was 0.525 ± 0.167% and 0.264 ± 0.113%, respectively. This suggests that climate change affected the division of the two lineages. Water deer sampled from the three Korean regions (26 locations) were slightly distinct in their genetic structure (AMOVA: F(ST) = 0.28416, P < 0.00001; Φ(ST) = 0.19239, P < 0.00001). Such slight population differentiation may be derived from differential dispersal ability in males and females. The use of genetic markers, such as nuclear microsatellite and Y-linked DNA markers, and samples collected from various localities in East Asia should improve our understanding of the water deer's genetic characteristics.

Fully roll-to-roll gravure printed rectenna on plastic foils for wireless power transmission at 13.56 MHz.

Wireless power transmission to inexpensive and disposable smart electronic devices is one of the key issues for the realization of a ubiquitous society where sensor networks such as RFID tags, price tags, smart logos, signage and sensors could be fully interconnected and utilized by DC power of less than 0.3 W. This DC power can be provided by inductively coupled AC from a 13.56 MHz power transmitter through a rectenna, consisting of an antenna, a diode and a capacitor, which would be cheap to integrate with inexpensive smart electronic devices. To integrate the rectenna with a minimum cost, a roll-to-roll (R2R) gravure printing process has been considered to print the rectenna on plastic foils. In this paper, R2R gravure printing systems including printing condition and four different nanoparticle based inks will be reported to print the rectenna (antenna, diode and capacitor) on plastic foils at a printing speed of 8 m min(-1) and more than 90% device yield for a wireless power transmission of 0.3 W using a standard 13.56 MHz power transmitter.

Simultaneous expression of allogenic class II MHC and B7.1 (CD80) molecules in A20 B-lymphoma cell line enhances tumor immunogenicity.

We expressed the allogenic class II MHC antigen and B7.1 (CD80) co-stimulatory molecule in A20 beta-lymphoma cells in order to test their efficacy as immuno-stimulating adjuvant agents in inducing tumor-specific immunity. The transduction of the allogenic I-Ab alpha and beta chain genes into A20 cell resulted in a surface expression of the allogenic class II MHC molecules. The expression of the allogenic class II MHC antigen (I-Ab) in A20 cells enhanced the proliferation of T cells in a mixed lymphocyte tumor culture and in vitro cytotoxic T lymphocyte (CTL) generation against parental cells. The B7.1 gene, which is known to be a potent co-stimulatory molecule, was also transduced and expressed in A20 cells, either alone or in combination with I-Ab. The B7.1 transduction alone leads to a similar in vitro immune enhancing effect as I-Ab. When both the I-Ab and B7.1 genes were transduced, the in vitro immunostimulating capacity was further enhanced. Finally, we also tested the A20 cells that were transduced with I-Ab and/or B7.1 for their efficacy as preventive tumor vaccines in vivo. The results indicate that the A20 cells that express both the I-Ab and B7.1 have more potent vaccinating potential, compared to the cells that express only one of the molecules.