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J Nat Prod ; 69(4): 580-4, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16643030

RESUMO

As part of our ongoing chemical investigation of biologically active metabolites from marine fungi, three new compounds, p-hydroxyphenopyrrozin (1) and diketopiperazines (3, 4), have been isolated from the marine-derived fungus Chromocleista sp. In addition, the fungus gave the known compound phenopyrrozin (2), four known diketopiperazines (6-9), N-acetyltryptamine (10), and agathic acid (11). Another new diketopiperazine (5) was separated and identified as a decomposition product of 3 and 4. The structures of the new metabolites were determined on the basis of mass spectroscopy, NMR experiments, and derivatization methods. The absolute configuration of 1 was determined by X-ray crystallography studies.


Assuntos
Ascomicetos/química , Pirróis/química , Pirróis/isolamento & purificação , Animais , Candida albicans/efeitos dos fármacos , Cristalografia por Raios X , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Leucemia P388 , Biologia Marinha , Camundongos , Testes de Sensibilidade Microbiana , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Oceanos e Mares , Pirróis/farmacologia , Células Tumorais Cultivadas
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