RESUMO
Forty-one adult males volunteered for a study designed to investigate the thrombogenicity of the Valium® vehicle. Utilizing a standardized protocol, each subject received a sedative dose of Injectable Valium® in the antecubital fossa of one arm and an equivalent volume of vehicle in the contralateral arm. Both were administered with a continuous infusion drip of 5 per cent dextrose in water. Post-operative evaluation extended over 10 weeks and included clinical observation and palpation. Ultrasonic tests for occluded or impaired blood flow were performed with a Doppler Flowmeter.Five subjects (12.2 percent) had venous sequelae with the Valium® and two (4.8 percent) developed sequelae with the vehicle. The incidence of venous sequelae reported in the present study was considerably lower than in previous investigations (66.6 per cent and 37.5 per cent) utilizing the same protocol. The present study indicates that time of continuous infusion appears to contribute to thrombophlebitis subsequent to intravenous injection of Valium®. It also appears that the diazepam vehicle is not the major factor in the occurrence of thrombophlebitis.
Assuntos
Diazepam/efeitos adversos , Veículos Farmacêuticos/efeitos adversos , Tromboflebite/induzido quimicamente , Adulto , Anestesia Intravenosa , Diazepam/administração & dosagem , Humanos , Injeções Intravenosas , MasculinoRESUMO
The sharpness of surgical instruments is of particular importance to the periodontist. In order to study the effects of sterilization on the cutting edges of periodontal curets and scalers, new sharpened instruments were sterilized 10 cycles with saturated steam, formalin-alcohol vapor or dry heat. The instruments were evaluated before and after sterilization with a scanning electron microscope. No visual damage to the cutting edges of stainless steel instruments was evident after sterilization by saturated steam at 250 degrees F, formalin-alcohol vapor at 270 degrees F or dry heat up to 340 degrees F. Carbon steel instruments were not damaged by formalin-alcohol vapor at 270 degrees F or dry heat up to 340 degrees F. Saturated steam caused oxidation and dulling of carbon steel instruments.
