1.
Chimia (Aarau)
; 71(12): 836-840, 2017 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29289244
RESUMO
Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases.