1.
Bioorg Med Chem Lett
; 10(8): 805-9, 2000 Apr 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10782691
RESUMO
A series of 3-(4-piperidinylthio)-1H-indoles was synthesized and evaluated in mice in the phenylbenzoquinone(PBQ)-induced writhing and hot plate tests. Most of these compounds are good analgesics with activities comparable to that of morphine. Among them compound 1i (UP 237-61), which has a strong serotonin binding profile, has an interesting antinociceptive activity which is not reversed by naloxone.