Duración de días de hospitalización psiquiátrica en pacientes con diagnósticos GES con y sin comorbilidades / Length of stay in psychiatric hospitalization in patients with GES diagnoses and its comorbidities

There are several descriptive studies of the use of mental health Services in the population served in the public system, however there are few references concerning the private system. Objective: To characterize a population with GES mental health pathology admitted in private mental health system in relation to the length of stay. Material and Methods: Medical charts were reviewed for 1,544 patients discharged from hospital admissions in private mental health centers. The following variables were recorded: age at diagnosis, sex, length of stay, number of hospitalizations and multiaxial diagnosis. Results: The average hospital stay for the sample was 21.05 days. The average hospital stay of men was 3.71 ± 2.46 days more than average women (p = 0.05). The average LOS was higher in younger patients. With regards to axis I, 68.52% of patients had severe major depression, 21.87% bipolar disorder in severe depressive phase and 6.87% schizophrenia. Axis I comorbidity was present in 17.94% of the sample. For Axis II, 57.97% of patients had personality disorders, with the borderline personality being the most frequent in both sexes (51.06% of patients with disorder of personality). The analysis of information shows that comorbidities did not significantly influence average days of hospitalization. Conclusions: This study is contributes to estimate the costs and the average stay in inpatient GES mental health patients in the private system.

Existen diversos estudios descriptivos del uso de servicios de Salud Mental en la población atendida en el sistema público, sin embargo, se encuentran pocas referencias respecto al sistema privado. Objetivo: Caracterizar a una población con patología de salud mental GES internada en centros privados de salud mental en relación a los días de hospitalización. Material y Método: Se revisaron 1.544 fichas de pacientes egresados de hospitalizaciones en centros privados de salud mental registrando las siguientes variables: edad al momento del diagnóstico, sexo, días de hospitalización, número de hospitalizaciones y diagnóstico según eje. Resultados: El promedio de días de hospitalización de la muestra fue de 21,05 días. El promedio de días de hospitalización de los hombres fue 3,71 ± 2,46 días mayor que el promedio de las mujeres (p = 0,05). El promedio de días de hospitalización fue más alto en los pacientes jóvenes. En el eje I, el 68,52% de los pacientes presentaron patología del ánimo en su forma monopolar; 21,76% patología del ánimo en su forma bipolar y un 6,87% fueron diagnosticados con esquizofrenia. La comorbilidad en el eje I se presentó en un 17,94% de la muestra. Respecto al eje II, el 57,97% presenta algún trastorno de la personalidad, siendo el trastorno de personalidad limítrofe el más frecuente en ambos sexos (51,06% del total de pacientes con trastorno de la personalidad). Del análisis de la información destaca que las comorbilidades no influyeron de forma significativa en el promedio de los días de hospitalización. Conclusiones: Este estudio constituye un aporte para estimar los costos y la estadía promedio en una hospitalización de pacientes GES de salud mental en el sistema privado.

Imidazole derivatives with potential biological activity.

A series of 1-substituted imidazole-5-carbohydroxamic acids Ia, Ib and Ic were prepared from the corresponding 5-methoxycarbonyl imidazoles (IX) obtained by a univocal synthesis starting with the reaction of the amines (III) with ethylchloroacetate. On treatment of 4(5)-methoxycarbonyl imidazoles (XI) with alkylaryl halides (X), on the contrary, mixtures of 1-substituted-4(or 5)-methoxycarbonyl imidazoles were obtained that, when separated by thin-layer chromatography, gave the carbohydroxamic acids Ia, Ib, Id and Ie and IIa leads to f. The structure of the imidazole derivatives were obtained by means of IR, NMR and UV spectra. On carrying out tests of biological activity on these compounds, it had been found that the 5-carbohydroxamic acids possess, compared to the 4-carbohydroxamic ones, a greater activity. Particularly Ib and Ib--HCl seem fairly active against Klebsiella pneumoniae and Clostridium bifermentans, Ib--HCl against Bacillus subtilis, too.

Synthesis of sulphonamidoquinoline derivatives.

In a research for new antimicrobial agents effective in therapy a new series of sulphonamidoquinoline derivatives have been studied. Their molecules, have got the feature of both 1-alkyl-1,4-dihydro-4-oxopyridine-3-carboxylic acid and sulphonamides. The structure of such compounds has been confirmed by chemical and physico-chemical methods and their antimicrobial activity has been tested.