[Mechanisms of the protective action of plant preparation erakond in influenza]. / Mekhanizmy protektivnogo deistviia fitopreparata érakond pri grippe.

The results of the study of some mechanisms of the protective action of Erakond, a phytopreparation intended for use in acute influenza infection are presented. In controlled animal observations Erakond was shown to induce the synthesis of antibodies in infected and immunized mice, the production of lymphokine, endogenic interferon; to increase the phagocytic and adhesive activity of mononuclears. The preparation facilitated the normalization of the process of the peroxide oxidation of lipids in mice and rendered a positive effect on the course of the inflammatory process in the lungs of mice at the final stage of influenza infection.

[Effect of macrophage decay products on the incorporation of H3-thymidine into pulmonary cells in rats]. / Vliianie produktov razrusheniia makrofaga na vkliuchenie 3H-timidina v kletki legkikh u krys.

3H-thymidine is injected to Wistar rats 60 min before their sacrifice, that is performed 24 h after intratracheal administration of isotonic solution of natrium chloride (control), and in the test animals--24 or 72 h after similar injection of macrophage decay products (MDP). The MDP are prepared by freezing-thawing of syngenic peritoneal macrophages repeated 5 times in the dose corresponding to 10(8) of the destroyed cells per 100 g of body mass. During the first period after MDP injection the labelling index of macrophages, histiocytes and cells of the alveolar epithelium increases up to 4.07 +/- 0.21%, during the second--up to 3.34 +/- 0.17% (in the control--1.90 +/- 0.18%). The results obtained are discussed according to modern ideas on the role of the interstitial cell pool as an immediate source for mobilization of alveolar macrophages, and together with the data previously accumulated, on the role of MDP in the autoregulatory control of various links of the macrophagal pulmonary reaction.

[Ultrastructural changes in central nervous system cells due to arboviruses]. / Ul'trastrukturnye izmeneniia v kletkakh tsentral'noi nervnoi sistemy, vyzyvaemye arbovirusami.

The paper systematizes the data of the literature on ultrastructural changes in the central nervous system (CNS) of experimental animals infected with arboviruses of the Togaviridae family. The main site of virus reproduction in the CNS was found to be nerve cells in which the ultrastructural lesions typical for this group of viruses developed. The main features of these lesions consist in degeneration of rough membranes, ribosomes, and polysomes of the cell, hyperplasia and hypertrophy of smooth membranes, formation of various vacuoles and vesicles in the cell hyaloplasm. Mature virions accumulate in cisterns and cavities of the endoplasmic reticulum, lamellar complex, in vacuoles and vesicles. Each of arboviruses produces in the cells not strictly specific but typical ultrastructural lesions. In the CNS the viruses spread hematogenically, in intercellular and perivascular spaces and dendrites of the nerve cells.

[Primary pathological changes in cells infected with tick-borne encephalitis virus]. / Pervichnye patologicheskie izmeneniia v kletkakh, zarazhennykh virusom kleshchevogo éntsefalita

Synthesis and the content of RNA and protein in cells of the pig embryo kidneys infected with tick--borne encephalitis virus were studied by means of autoradiography and cytophotometry. Acceleration of synthesis and accumulation of RNA (in cellular structures) were estimated as over 125--200% of the initial level followed by a decrease in 12 hr when the virus release from the cells occurred. By the 2nd and 6--8th hr of infection (in the period of synthesis of early and late virus material), two peaks of protein contents over 123--131% were observed. The RNA and protein shifts are well correlated with the virus reproduction stages.