Exercising in Air Pollution: The Cleanest versus Dirtiest Cities Challenge.

Background: Aerobic exercise is recommended to improve health. However, the increased ventilation might increase the doses of inhaled air pollutants, negating the health benefits in highly polluted areas. Our objective was to estimate the inhaled dose of air pollutants during two simulated exercise sessions at cleanest and dirtiest cities reported by World Health Organization (WHO) considering air quality. Methods: Minute ventilation data were extracted from laboratory-based exercise of 116 incremental running tests and used to calculate total ventilation of a hypothetical 30-min moderate continuous exercise routine. Afterwards, total ventilation values were combined with particulate matter (PM) data reported by the WHO for the 10 cleanest and 10 dirtiest cities, to calculate inhaled doses and the relative risk of all-cause mortality by exercising in different air pollution concentrations. Findings: The dirtiest cities are located at less developed countries compared to cleanest cities. The inhaled dose of PM2.5 and PM10 were significantly higher in the dirtiest cities compared to the cleanest cities at rest and exercise, and significantly higher during exercise compared to the rest at dirtiest cities. The relative risk of all-cause mortality analysis showed that, while exercise in the cleanest cities improved health benefits throughout up to 90 min, there were no further health benefits after 15 min of exercise in the dirtiest cities, and the air pollution health risks surpassed the exercise benefits after 75 min. Interpretation: Our findings suggest that a traditional 30-min of moderate aerobic exercise session might induce inhalation of high levels of pollutants when performed at dirtiest cities. Considering several adverse health effects from air pollutants inhalation, so the results suggest that the air pollution levels of the cities should be taken into account for physical exercise recommendations.

Parasympathetic activity delayed after self-paced exercise.

The main purpose of this study was to compare the effect of the constant load and self-paced exercise with similar total work on autonomic control after endurance exercise. Ten physically active men were submitted to (i) a maximal incremental exercise test, (ii) a 4-km cycling time trial (4-km TT), and (iii) a constant workload test with identical total external work performed at 4-km TT. Gas exchange was measured throughout the tests, while blood lactate, heart rate, and heart rate variability (HRV) were measured during the passive recovery. Power output measured at the last lap (i.e. 3600-4000 m) of 4-km TT (316 ± 89 W) was statistically higher than power output measured at the end of the constant workload exercise (211 ± 42 W). The 4-km TT produced higher values of blood lactate concentration (8.8 ± 2.1 mmol L-1) than the constant workload test (7.8 ± 2.1 mmol L-1). The heart rate recovery measured at 60 s (constant workload: 37 ± 7 bpm; 4-km TT: 30 ± 6) and 120 s (constant workload: 57 ± 9 bpm; 4-km TT: 51 ± 9 bpm) were higher in the constant workload than in the self-paced exercise. The HRV (i.e. RMSSD30s) was statistically higher in the constant load exercise measured at 120, 420, 450, 480, 540, and 570 s than the self-paced exercise. These findings suggest that the autonomic control responses were dependent of the endurance exercise modalities, with parasympathetic activity being delayed after self-paced exercise, as evidenced by post-exercise heart rate indices.

ACtn3 e desempenho esportivo: um gene candidato ao sucesso em provas de curta e longa duração / ACTN3 gene and sports performance: a candidate gene to success in short and long duration events

O presente estudo revisou evidências acerca da relação entre o polimorfismo R577X do gene ACTN3 e o desempenho esportivo. Foram acessados estudos na base Pubmed através das palavras-chave: ACTN3 gene e sports performance. O gene ACTN3 codifica para uma proteína presente nas fibras musculares esqueléticas tipo II, a α-actinina-3. A maioria dos estudos demonstra uma relação entre a presença da α-actinina-3 e a capacidade de geração de força muscular. Porém, estudos recentes apontam que a ausência da forma funcional dessa proteína pode regular a utilização de substratos durante o exercício, priorizando o metabolismo oxidativo, poupando glicogênio muscular e favorecendo o desempenho em atividades de longa duração. Porém, ainda são necessários mais estudos envolvendo humanos para elucidar melhor esse papel metabólico.

The aim of the present study was to review the evidence on the relationship between the R577X polymorphism of the ACTN3 gene and sports performance. The Pubmed database was searched using ACTN3 gene AND sports performance as keywords. The ACTN3 gene encodes a muscle-specific protein, called α-actinin-3, which is only present in type II fibers. Most studies have demonstrated a relationship between the presence of α-actinin-3 and the ability of muscle to generate force. However, recent studies suggest that the absence of the functional form of this protein may regulate substrate utilization during exercise, giving priority to oxidative metabolism, sparing muscle glycogen, and improving performance in long-duration events. Nevertheless, further studies involving humans are needed to better understand the metabolic role of this protein.

É possível determinar a economia de corrida através do teste progressivo até a exaustão? / Is possible to predict running economy using maximal incremental exercise test?

O objetivo do presente estudo foi verificar a possibilidade de se estimar a economia de corrida (EC) a partir do coeficiente angular gerado pela relação VO2 vs. intensidade de testes progressivos até a exaustão (EC INCLINA). Para tanto, 16 corredores de provas de longa duração (idade 32 ± 7 anos, massa corporal 70,0 ± 6,7 kg, estatura 173,3 ± 5,0 cm, O2máx 57,9 ± 5,8 ml·kg-1·min-1) foram submetidos a um teste incremental e a dois testes de cargas constantes (12 km·h-1 e a intensidade de 90 por cento do segundo limiar ventilatório) para a mensuração da EC. Foram detectadas correlações fracas entre o EC INCLINA e a EC estabelecida a 12 km·h-1 (r = 0,49; p = 0,054) e na intensidade de 90 por cento do segundo limiar ventilatório (r = 0,55; p = 0,027). Além disso, o EC INCLINA também estava negativamente correlacionado com a concentração sanguínea de lactato (r = -0,75; p = 0,001) e a razão de troca respiratória (r = -0,80; p < 0,001) mensuradas ao final no teste progressivo. Portanto, esses achados sugerem que, embora a sua aplicação para determinar a EC seja limitada, o EC INCLINA pode ser um parâmetro alternativo empregado para o diagnóstico da aptidão de corredores de provas de longa duração devido a sua relação com o metabolismo anaeróbio.

The purpose of the present study was to investigate the association between running economy (RE) and the slope of the regression line obtained as the individual relationship between oxygen uptake and the corresponding intensity in the incremental test (EC INCLINA). Sixteen recreational long-distance runners (age 32 ± 7 years, body mass 70,0 ± 6.7 kg, height 173.3 ± 5.0 cm, VO2max 57.9 ± 5.8 ml·kg-1·min-1) performed a progressive incremental test and two submaximal workload tests (at 12 km·h-1 and 90 percent second ventilatory threshold) to determine the RE. There was significant correlation between EC INCLINA and RE measured at 12 km·h-1 (r = 0.49; p = 0.054) and at 90 percent second ventilatory threshold (r = 0.55; p = 0.027). In addition, EC INCLINA also was negatively correlated with peak blood lactate (r = -0.75; p = 0.001) and peak respiratory exchange rate (r = -0.80; p < 0.001). These findings suggest that EC INCLINA would be an alternative parameter employed to determine the endurance performance in recreational long-distance runners.