RESUMO
En los últimos tiempos, las técnicas computacionales se han constituido en valiosas herramientas para la investigación de sistemas biológicos. Ellas pueden guiar proyectos y complementar métodos experimentales en diversas áreas de aplicación, como la medicina, alimentación y agricultura. En este artículo resumimos y actualizamos los principales conocimientos acerca de los métodos utilizados por la bioinformática y brindamos algunos ejemplos de sus contribuciones en distintos campos. Enfatizamos en el diseño y descubrimiento de nuevas drogas de origen natural, principalmente antimicrobianas. En este sentido, la búsqueda de nuevos medicamentos y estrategias farmacológicas está plenamente justificada por distintas razones, que incluyen la emergencia de resistencia e interacciones farmacológicas, particularmente en pacientes inmunocomprometidos.
In the last times, computational techniques have become valuable tools for research of biological systems. They can lead and complementexperimental methods in different fields of application such as medicine, bromatology and agriculture.In this review we summarize the main knowledge on bioinformatic tools and give some examples of their contributions in diverseknowledge areas. We make emphasis in the design and discovery of new potential drugs, mainly antimicrobial agents of natural origin.In this sense, the search for new medicaments or pharmacological strategies is fully justified because of different reasons, includingemergence of resistance and pharmacological interactions, in particular in immunocompromised patients.
Assuntos
Humanos , Produtos Biológicos , Biologia Computacional , Anti-Infecciosos/farmacologia , Anti-Infecciosos/uso terapêutico , Desenho de Fármacos , Interações Medicamentosas , Modelos EducacionaisAssuntos
Gengiva/fisiologia , Gengivoplastia/métodos , Contenções Periodontais , Extração Dentária/métodos , Aumento do Rebordo Alveolar , Transplante Ósseo/métodos , Estética Dentária , Gengiva/transplante , Regeneração Tecidual Guiada Periodontal , Humanos , Incisivo , Membranas Artificiais , Projetos Piloto , Resultado do Tratamento , CicatrizaçãoRESUMO
A reproducible method is described for the determination of the MICs of ketoconazole, miconazole, fluconazole, and itraconazole with sharp endpoints when employed with either yeasts or molds. A semisolid medium is used with controlled pH and standardized inoculum. The time of reading results is a critical factor in the conduct of this test. The medium is simple to prepare and has a relatively long refrigerator shelf life in a user-ready state, requiring only the addition of a freshly prepared inoculum after restoration to room temperature.
Assuntos
Antifúngicos/farmacologia , Azóis/farmacologia , Fungos/efeitos dos fármacos , Fluconazol , Humanos , Itraconazol , Cetoconazol/análogos & derivados , Cetoconazol/farmacologia , Miconazol/farmacologia , Testes de Sensibilidade Microbiana/métodos , Triazóis/farmacologiaRESUMO
We have presented two clinical case reports of patients with TMJ dysfunction syndrome as an example of coordinated treatments between dentists and physical therapists. The clinical profiles of these patients with craniocervical pain were compiled from comprehensive physical therapy and dental-orthopedic evaluations. The significance of the relationship between the rest position of the mandible and forward head posture has been shown by the changes observed after correction of the postural deviations and vertical resting dimensions by dental treatments and physical therapy. Additional research is necessary to determine long-term effects of this combined approach in TMJ dysfunction syndrome.