Assuntos
Cateterismo Cardíaco , Ablação por Cateter , Proteção Radiológica , Radiografia Intervencionista , Abdome/efeitos da radiação , Angioplastia Coronária com Balão , Dorso/efeitos da radiação , Técnicas Eletrofisiológicas Cardíacas , Feminino , Fluoroscopia , Virilha/efeitos da radiação , Humanos , Masculino , Pessoa de Meia-Idade , Proteção Radiológica/instrumentação , Dosimetria TermoluminescenteRESUMO
Torsades de pointes (TdP) is polymorphic ventricular tachycardia occurring in the setting of a prolonged cardiac repolarization. Drug interactions between macrolide antibiotics such as erythomycin and pharmacologic agents that prolong the QT interval have been known to cause TdP. However, clarithromycin is thought to be less frequently associated with drug induced TdP, because it inactivates hepatic cytochrome P-450 to a lesser extent than erythromycin. We describe a case of TdP caused by a drug interaction in a 76-year-old woman taking long-term disopyramide after she was given clarithromycin concomitantly for chronic bronchitis.
Assuntos
Antiarrítmicos/efeitos adversos , Antibacterianos/efeitos adversos , Claritromicina/efeitos adversos , Disopiramida/efeitos adversos , Torsades de Pointes/induzido quimicamente , Idoso , Interações Medicamentosas , Feminino , HumanosRESUMO
A single coronary artery is a rare cause of cardiac ischemia, congestive heart failure, and sudden death. We report the second known antemortem diagnosis of a single right coronary artery supplying the entire myocardium.
Assuntos
Anomalias dos Vasos Coronários/diagnóstico , Angiografia Coronária , Anomalias dos Vasos Coronários/complicações , Feminino , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-IdadeRESUMO
Tight transcriptional control of foreign genes introduced into the germline of transgenic mice would be of great experimental value in studies of gene function. To develop a system in which the spatial and temporal expression of candidate genes implicated in cardiac development or function could be tightly controlled in vivo, we have generated transgenic mice expressing a tetracycline-controlled transactivator (tTA) under the control of a rat alpha myosin heavy chain promoter (MHC alpha-tTA mice), as well as mice harboring a candidate target gene implicated in the control of differentiation, Id1 (tet-Id1 mice). No expression of the target transgene was detected in any tissues of hemizygous tet-Id1 mice. Genetic crosses with MHC alpha-tTA mice resulted in transactivation of the Id1 transgene, but expression was restricted to heart, where tTA was expressed. Furthermore, transactivation of the target gene was tightly and reversibly controlled by systemic therapy with tetracycline, both in utero and postnatally. These studies demonstrate the feasibility of such a binary approach for tightly controlling the timing and extent of expression of transgenes in vivo. This approach should be generally useful for the ectopic expression of candidate genes in selected tissues during delineated developmental stages.
