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1.
Clin. transl. oncol. (Print) ; 20(1): 75-83, ene. 2018. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-170470

RESUMO

Head and neck cancer (HNC) is defined as malignant tumours located in the upper aerodigestive tract and represents 5% of oncologic cases in adults in Spain. More than 90% of these tumours have squamous histology. In an effort to incorporate evidence obtained since 2013 publication, Spanish Society of Medical Oncology (SEOM) presents an update of HNC diagnosis and treatment guideline. The eighth edition of TNM classification, published in January 2017, introduces important changes for p16-positive oropharyngeal tumours, for lip and oral cavity cancer and for N3 category. In addition, there are new data about induction chemotherapy and the role of immunotherapy in HNC (AU)


No disponible


Assuntos
Humanos , Neoplasias de Cabeça e Pescoço/terapia , Neoplasias Orofaríngeas/terapia , Quimioterapia de Indução/métodos , Guias de Prática Clínica como Assunto , Fatores de Risco , Tabagismo/complicações , Infecções por Papillomavirus/complicações
2.
Clin Transl Oncol ; 20(1): 75-83, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29159792

RESUMO

Head and neck cancer (HNC) is defined as malignant tumours located in the upper aerodigestive tract and represents 5% of oncologic cases in adults in Spain. More than 90% of these tumours have squamous histology. In an effort to incorporate evidence obtained since 2013 publication, Spanish Society of Medical Oncology (SEOM) presents an update of HNC diagnosis and treatment guideline. The eighth edition of TNM classification, published in January 2017, introduces important changes for p16-positive oropharyngeal tumours, for lip and oral cavity cancer and for N3 category. In addition, there are new data about induction chemotherapy and the role of immunotherapy in HNC.


Assuntos
Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/terapia , Humanos
3.
Oral Oncol ; 63: 38-43, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27938998

RESUMO

OBJECTIVES: To examine the relationship between polymorphisms of the epidermal growth factor receptor (EGFR) pathway and toxicity in head and neck squamous cell carcinoma (HNSCC) patients treated with cetuximab. MATERIAL AND METHODS: Multicenter, retrospective, observational pilot study which included 110 patients with histologically-confirmed human papillomavirus (HPV) negative HNSCC in locally advanced stages (III-IVA-B) and who were treated with chemotherapy and radiotherapy plus cetuximab between 2003 and 2013. Genetic analyses for single nucleotide polymorphisms (SNP) in genes EGFR, CCDN1, FCGR2A, FCGR3A and KRAS-LCS6 were performed though available allelic discrimination assay and/or polymerase chain reaction-restriction fragment length polymorphism methods. RESULTS: Acneiform rash was observed in 55.5% of patients, dry skin in 45.5% and pruritus in 20.9%. A significant association with dry skin and global cetuximab-related toxicity was observed for the KRAS-LCS6 (rs61764370) variant (p<0.05); carriers of the G allele (genotypes TG+GG) in the dominant model were observed to have a decreased susceptibility of developing dry skin (OR=0.287 [95%CI=0.119-0.695]). Carriers of the A (GA+AA) allele for EGFR (rs2227983) showed a decreased risk of suffering from pruritus (OR=0.345 [0.124-0.958]). Similarly, KRAS (rs1801274) was related with lower global cetuximab-related toxicity (OR=0.266 [0.114-0.622]). CONCLUSION: This pilot study provides preliminary evidence supporting genetic variation of EGFR (rs2227983), KRAS (rs61764370) and FCGR2A (rs180127) as useful biomarkers for predicting reduced skin toxicity in HNSCC patients treated with a cetuximab-based therapy. Alternative therapeutic options should be explored for these patients.


Assuntos
Antineoplásicos Imunológicos/efeitos adversos , Carcinoma de Células Escamosas/tratamento farmacológico , Cetuximab/efeitos adversos , Receptores ErbB/genética , Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Polimorfismo Genético , Antineoplásicos Imunológicos/uso terapêutico , Cetuximab/uso terapêutico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Espanha , Carcinoma de Células Escamosas de Cabeça e Pescoço
4.
Clin. transl. oncol. (Print) ; 18(11): 1114-1122, nov. 2016. tab
Artigo em Inglês | IBECS | ID: ibc-156877

RESUMO

Purpose. Head and neck cancer is a highly heterogeneous disease comprising a large number of tumors located in the cervicofacial area. This study aimed to determine the epidemiological characteristics of squamous-cell carcinomas of the head and neck in the Spanish population, and the distribution of risk factors based on tumor locations. Methods/patients. A cohort of 459 patients (75 oral cavity, 167 oro-/hypopharyngeal and 217 laryngeal cancers) recruited in 19 hospitals participating in the Spanish head and neck cancer cooperative group were included over 3 years (2012-2014). Epidemiological parameters and risk factors were obtained from a self-administered questionnaire, and tumor characteristics were obtained from clinical records. Multivariate multinomial logistic regression was used to assess factors associated with tumor location. Results. Most patients were males (88.4 %), smokers (95 %) and drinkers (76.5 %). Relative to laryngeal cancer, pharyngeal cancer and oral cancer were more common in women than men (OR 3.58, p = 0.003 and 4.33, p = 0.001, respectively); pharyngeal cancer was more associated with rural environment (OR 1.81, p = 0.007) and weekly alcohol intake (10-140 g: OR 2.53, p = 0.012; 141-280 g: OR 2.47, p = 0.023; >280 g: OR 3.20, p = 0.001) and less associated with pack-years of smoking (21-40 packs: OR 0.46, p = 0.045; 41-70 packs: OR 0.43, p = 0.023; ≥71 packs: OR 3.20, p = 0.015). Conclusions. The distribution of these tumors differs between the sexes, with a higher proportion of oral cavity and pharyngeal tumors in women than in men. Oro-/hypopharyngeal cancers were more strongly associated with rural areas and with alcohol consumption, although less strongly associated with smoking than laryngeal tumors (AU)


No disponible


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/epidemiologia , Carcinoma de Células Escamosas/diagnóstico , Fatores de Risco , Neoplasias Laríngeas/complicações , Estudos de Coortes , Análise Multivariada , Inquéritos e Questionários
5.
Clin Transl Oncol ; 18(11): 1114-1122, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27112939

RESUMO

PURPOSE: Head and neck cancer is a highly heterogeneous disease comprising a large number of tumors located in the cervicofacial area. This study aimed to determine the epidemiological characteristics of squamous-cell carcinomas of the head and neck in the Spanish population, and the distribution of risk factors based on tumor locations. METHODS/PATIENTS: A cohort of 459 patients (75 oral cavity, 167 oro-/hypopharyngeal and 217 laryngeal cancers) recruited in 19 hospitals participating in the Spanish head and neck cancer cooperative group were included over 3 years (2012-2014). Epidemiological parameters and risk factors were obtained from a self-administered questionnaire, and tumor characteristics were obtained from clinical records. Multivariate multinomial logistic regression was used to assess factors associated with tumor location. RESULTS: Most patients were males (88.4 %), smokers (95 %) and drinkers (76.5 %). Relative to laryngeal cancer, pharyngeal cancer and oral cancer were more common in women than men (OR 3.58, p = 0.003 and 4.33, p = 0.001, respectively); pharyngeal cancer was more associated with rural environment (OR 1.81, p = 0.007) and weekly alcohol intake (10-140 g: OR 2.53, p = 0.012; 141-280 g: OR 2.47, p = 0.023; >280 g: OR 3.20, p = 0.001) and less associated with pack-years of smoking (21-40 packs: OR 0.46, p = 0.045; 41-70 packs: OR 0.43, p = 0.023; ≥71 packs: OR 3.20, p = 0.015). CONCLUSIONS: The distribution of these tumors differs between the sexes, with a higher proportion of oral cavity and pharyngeal tumors in women than in men. Oro-/hypopharyngeal cancers were more strongly associated with rural areas and with alcohol consumption, although less strongly associated with smoking than laryngeal tumors.


Assuntos
Carcinoma de Células Escamosas/epidemiologia , Carcinoma de Células Escamosas/patologia , Neoplasias de Cabeça e Pescoço/epidemiologia , Neoplasias de Cabeça e Pescoço/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Consumo de Bebidas Alcoólicas/efeitos adversos , Carcinoma de Células Escamosas/etiologia , Feminino , Neoplasias de Cabeça e Pescoço/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Fumar/efeitos adversos , Espanha/epidemiologia , Carcinoma de Células Escamosas de Cabeça e Pescoço
6.
Clin. transl. oncol. (Print) ; 12(11): 742-748, nov. 2010. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-124368

RESUMO

Head and neck cancer constitutes the fifth highest cause of cancer in Spain. It is a neoplasm with a high possibility of cure if it is diagnosed in early stages, but unfortunately two thirds of the patients are diagnosed at an advanced loco-regional stage (stage III and IV, without metastasis). The multidisciplinary team, bringing together all professionals who specialize in the diagnosis and treatment of these tumors make the decision to establish the best sequence of individualized diagnosis, staging and treatment for each patient. This guide gives recommendations for diagnosis, staging and treatment for squamous cell carcinoma of the head and neck. In order to simplify the amount of information about any subsite of the head and neck area, the treatment recommendations are summarized as local disease, locally advance resectable and unresectable stages, function-preserving laryngeal treatment and recurrent and metastatic disease (AU)


Assuntos
Humanos , Masculino , Feminino , Carcinoma de Células Escamosas/terapia , Neoplasias de Cabeça e Pescoço/terapia , Carcinoma de Células Escamosas/epidemiologia , Guias de Prática Clínica como Assunto , Algoritmos , Oncologia/métodos , Oncologia/organização & administração , Oncologia/tendências , Sociedades Médicas/organização & administração , Sociedades Médicas/normas , Sociedades Médicas , Espanha/epidemiologia
7.
Clin. transl. oncol. (Print) ; 12(11): 749-752, nov. 2010. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-124369

RESUMO

Nasopharyngeal carcinoma is an unusual tumour in Spain. It has differences in epidemiology, histology, clinical behaviour, treatment and prognosis from those of other head and neck neoplasms, which justifies separate analysis. It is a neoplasm with a high possibility of cure with a combined treatment if even it is diagnosed in an advanced locoregional stage (stage III or IV, without metastasis). The multidisciplinary team, bringing together all professionals who specialize in the diagnosis and treatment of these tumors make the decision to establish the best sequence of individualized diagnosis, staging and treatment for each patient. This guide gives recommendations for diagnosis, staging and treatment for nasopharyngeal carcinoma. The treatment recommendations are summarized as local disease, locally advance and recurrent and metastatic disease (AU)


Assuntos
Humanos , Masculino , Feminino , Carcinoma/epidemiologia , Carcinoma/terapia , Neoplasias Nasofaríngeas/epidemiologia , Neoplasias Nasofaríngeas/terapia , Guias de Prática Clínica como Assunto , Algoritmos , Oncologia/métodos , Oncologia/organização & administração , Oncologia/tendências , Sociedades Médicas/organização & administração , Sociedades Médicas/normas , Sociedades Médicas , Espanha/epidemiologia
8.
Oncología (Barc.) ; 25(10): 460-465, oct. 2002. tab, graf
Artigo em Es | IBECS | ID: ibc-19730

RESUMO

Objetivo: Revisión retrospectiva de nuestra experiencia en el tratamiento del carcinoma de nasofaringe. Material y método: Analizamos 38 pacientes (26 hombres, 12 mujeres). Realizamos análisis de supervivencia mediante el método de Kaplan y Meier. Resultados: La mediana de edad de la serie fue de 44 años (15-78). El 93 por ciento de los pacientes presentaban estadios avanzados al diagnóstico. El tratamiento fue: radioterapia 12 pacientes (32 por ciento), radioterapia y quimioterapia 24 casos (63 por ciento), radioterapia y cirugía 1 paciente (3 por ciento) y cirugía 1 caso (3 por ciento). Tasa de respuesta fue de 87 por ciento (82 por ciento RC, 5 por ciento RP). La tasa de recaída fue del 50 por ciento. La mediana del tiempo hasta la progresión fue de 16.6 meses y la de supervivencia de 54 meses con una supervivencia proyectada a 10 años del 38 por ciento. Conclusiones: El carcinoma de nasofaringe es un tumor diferente al resto de tumores de cabeza y cuello. La radioterapia ha sido clásicamente el tratamiento estándar. Actualmente en tumores no metastáticos la combinación de quimioterapia y radioterapia debe ser el tratamiento estándar. El papel de la quimioterapia como tratamiento adyuvante está por definir. (AU)


Assuntos
Adolescente , Adulto , Idoso , Feminino , Masculino , Pessoa de Meia-Idade , Humanos , Neoplasias Nasofaríngeas/terapia , Estudos Retrospectivos , Intervalo Livre de Doença , Progressão da Doença , Resultado do Tratamento
9.
Rev Clin Esp ; 199(11): 725-8, 1999 Nov.
Artigo em Espanhol | MEDLINE | ID: mdl-10638237

RESUMO

BACKGROUND: The diagnosis of second malignancies in patients with multiple myeloma is uncommon. It is debatable whether this tumor is in itself a risk factor for the incidence of second malignancies. Etiopathogenic factors which might account for this association were analyzed. MATERIALS AND METHODS: Retrospective analysis of a series of 210 patients with myeloma controlled by a Medical Oncology Department from 1984 to 1998. After searching for the diagnosis of a second malignancy, thirteen patients were identified with both diagnoses. A descriptive statistical study was elaborated as well as an analysis of survival. RESULTS: There were seven males and six females, with a mean age at diagnosis of 69 years (57-80). The Durie-Salmon stages at diagnosis were: I-A (3), I-B (1), II-A (4), III-A (4). Associated solid malignancies included: hepatocarcinoma (2), prostate adenocarcinoma (2), soft tissue sarcoma (2), lung adenocarcinoma (1), cholangiocarcinoma (1), breast carcinoma (1), endometrial carcinoma (2) and bladder carcinoma (1). At diagnosis, seven of the solid malignancies were metastatic. At the time of this analysis, eleven patients had died, eight because of progression of the solid cancer, two because of progression of myeloma and one because of therapy toxicity. Two patients are still alive with stability of the myeloma and solid malignancy controlled after surgical resection. CONCLUSIONS: The association was observed in 6.2% of patients with myeloma and occurs at an advanced age. IgG myelomas and in early stages predominated. Solid malignancies were diagnosed in advanced stages in most cases. A short term high mortality rate was observed due to progression of the solid malignancy. The frequency of the association did not seem to be higher than the overall incidence of second malignancies in patients with cancer.


Assuntos
Mieloma Múltiplo/complicações , Segunda Neoplasia Primária , Adenocarcinoma/diagnóstico , Adenocarcinoma/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Antineoplásicos/uso terapêutico , Neoplasias dos Ductos Biliares/diagnóstico , Neoplasias dos Ductos Biliares/tratamento farmacológico , Ductos Biliares Intra-Hepáticos , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/tratamento farmacológico , Carcinoma Hepatocelular/diagnóstico , Carcinoma Hepatocelular/tratamento farmacológico , Colangiocarcinoma/diagnóstico , Colangiocarcinoma/tratamento farmacológico , Neoplasias do Endométrio/diagnóstico , Neoplasias do Endométrio/tratamento farmacológico , Feminino , Humanos , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/tratamento farmacológico , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Mieloma Múltiplo/tratamento farmacológico , Segunda Neoplasia Primária/diagnóstico , Segunda Neoplasia Primária/tratamento farmacológico , Neoplasias da Próstata/diagnóstico , Neoplasias da Próstata/tratamento farmacológico , Estudos Retrospectivos , Sarcoma/diagnóstico , Sarcoma/tratamento farmacológico , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/tratamento farmacológico , Neoplasias da Bexiga Urinária/diagnóstico , Neoplasias da Bexiga Urinária/tratamento farmacológico
11.
Rev Clin Esp ; 197(11): 768-70, 1997 Nov.
Artigo em Espanhol | MEDLINE | ID: mdl-9580063

RESUMO

Multiple primary neoplasms are increasing in clinical practice, which is mainly due to the longer survival of cancer patients. Radiotherapy at an early stage of Hodgkin disease or lymphoma is well known to be associated with the future occurrence of secondary thyroid cancer. Nevertheless, the synchronous presentation of these two types of neoplasms is exceptional. We report here three cases of synchronic diagnosis of thyroid carcinoma and a malignant lymphoproliferative disease in patients who had not previously received radiotherapy nor chemotherapy. In malignant tumours of synchronic presentation, there is usually and underlying genetic predisposition involved in the etiology. In our patients, no carcinogenic environmental factor was demonstrated and, while this neoplastic association might be casual, an investigation on the possible individual predisposing factors would be warranted.


Assuntos
Doença de Hodgkin , Linfoma não Hodgkin , Neoplasias Primárias Múltiplas , Neoplasias da Glândula Tireoide , Adolescente , Adulto , Feminino , Doença de Hodgkin/diagnóstico , Doença de Hodgkin/terapia , Humanos , Linfoma não Hodgkin/diagnóstico , Linfoma não Hodgkin/terapia , Masculino , Neoplasias Primárias Múltiplas/diagnóstico , Neoplasias Primárias Múltiplas/terapia , Neoplasias da Glândula Tireoide/diagnóstico , Neoplasias da Glândula Tireoide/terapia
13.
An Med Interna ; 8(9): 448-50, 1991 Sep.
Artigo em Espanhol | MEDLINE | ID: mdl-1958781

RESUMO

The group of rounded small-cell tumors include different neoplasias involving different therapies; we can name neuroblastoma, Ewing' sarcoma, embrionary rhabdomyosarcoma, lymphoma and other pathology such as Askin's tumor or small cell tumor of the thorax area. Based on microscopic and immunohistochemistry findings, it is suggested that it originates from the neural crest or pluri-potential cells from the neuroectodermy. This has a very aggressive behaviour and is usually resistant to oncologic therapies.


Assuntos
Neoplasias Torácicas/patologia , Adolescente , Adulto , Feminino , Humanos , Masculino , Neoplasias Torácicas/terapia
14.
An Med Interna ; 6(12): 651-5, 1989 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-2491478

RESUMO

Thymomas are non-frequent neoplasias which are interesting because of their special association with the immune system pathology; although the pathogenic relationship has yet to be confirmed. A literature review is carried out on clinical aspects, prognosis and treatment, basically chemotherapy in advanced cases. Although they are classically categorized as benign, they are nevertheless considerably aggressive and maintain a low response to most active oncology treatment.


Assuntos
Timoma , Neoplasias do Timo , Terapia Combinada , Humanos , Cuidados Pré-Operatórios , Timectomia , Timoma/classificação , Timoma/diagnóstico , Timoma/patologia , Timoma/terapia , Neoplasias do Timo/classificação , Neoplasias do Timo/diagnóstico , Neoplasias do Timo/patologia , Neoplasias do Timo/terapia
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