RESUMO
Hepatotoxicity may complicate therapy with methotrexate in patients with rheumatoid arthritis. Prevention of cirrhosis may depend upon early identification of liver damage, usually accomplished by serial biopsy. To determine the adequacy of noninvasive methods for identifying hepatotoxicity, 22 sets of data were obtained in patients undergoing therapy with methotrexate for rheumatoid arthritis. Comparisons were made between liver biopsy, hepatocellular enzymes and two noninvasive radioisotopic methods that have been shown to be abnormal in hepatocellular disease: the rate constant of excretion of the 14C-aminopyrine and the time from injection to peak hepatic activity of 99mTc-diisopropylimidodiacetic acid. The hepatocellular enzymes and the time-to-peak-activity of diisopropylimidodiacetic acid were not useful predictors of methotrexate-induced hepatotoxicity. The aminopyrine breath test was abnormal in approximately half the patients with hepatotoxicity but showed poor specificity. Noninvasive methods remain inferior to biopsy for the detection of mild to moderate methotrexate-induced hepatotoxicity in patients with rheumatoid arthritis.
Assuntos
Artrite Reumatoide/tratamento farmacológico , Fígado/efeitos dos fármacos , Metotrexato/efeitos adversos , Adulto , Idoso , Alanina Transaminase/sangue , Aminopirina , Aspartato Aminotransferases/sangue , Biópsia , Testes Respiratórios , Ensaios Enzimáticos Clínicos , Humanos , Iminoácidos , Fígado/diagnóstico por imagem , Fígado/enzimologia , Fígado/patologia , Cirrose Hepática/induzido quimicamente , Cirrose Hepática/diagnóstico , Pessoa de Meia-Idade , Compostos de Organotecnécio , Valor Preditivo dos Testes , Cintilografia , Sensibilidade e Especificidade , Disofenina Tecnécio Tc 99mRESUMO
Polyvinyl alcohol sponge (PVA) radiolabeled with 99mTc-sulfur colloid was used to evaluate a large hepatic arteriovenous malformation (AVM) in a 71-yr-old white female prior to embolization. The patient had hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu) with severe left-to-right shunting through the hepatic AVM which resulted in high-output congestive heart failure. The patient also had severe pulmonary hypertension. Scintigraphic imaging of the embolized radiolabeled PVA particles allowed us to be certain that the particles did not flow through the liver and inadvertently embolize the lungs; with the patient's already poor pulmonary status, embolization could have been fatal.
Assuntos
Malformações Arteriovenosas/diagnóstico por imagem , Embolização Terapêutica , Artéria Hepática , Polivinil/uso terapêutico , Coloide de Enxofre Marcado com Tecnécio Tc 99m , Telangiectasia Hemorrágica Hereditária/complicações , Idoso , Malformações Arteriovenosas/terapia , Débito Cardíaco Elevado/complicações , Feminino , Insuficiência Cardíaca/complicações , Artéria Hepática/anormalidades , Humanos , Hipertensão Pulmonar/complicações , CintilografiaRESUMO
It is widely known that narcotics, such as morphine, cause spasm of the sphincter of Oddi, increasing pressure in the common bile duct. This pharmacologic effect has been applied to hepatobiliary scintigraphy in patients with chronic cholecystitis or cholestasis to reducing the time required for a diagnostic study. However, this feature of narcotics could result in delayed or nonvisualization of the small bowel, simulating a distal common bile duct obstruction, in patients requiring parenteral narcotic analgesics who must undergo hepatobiliary scintigraphy. We report on three patients where administration of intravenous naloxone hydrochloride (Narcan), a narcotic antagonist, was helpful in distinguishing narcotic-induced spasm of the sphincter of Oddi from true obstruction of the common bile duct.