1.
J Org Chem
; 88(6): 3965-3969, 2023 Mar 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36854174
RESUMO
The synthesis of a new family of naphthalenoid C2-symmetric clefts has been realized through a four-step synthetic sequence giving three C2-symmetric clefts and a rare nonsymmetric example. Subsequently, stereoselective reduction of the carbonyl groups at C-8 and C-16 then provides cleft molecules with hydrogen bonding potential. Using single-crystal X-ray and computational analysis, the cleft angle of the dione has been determined.