1.
Chem Commun (Camb)
; 47(38): 10569-71, 2011 Oct 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21863200
RESUMO
Glycosylated analogues of novobiocin, discovered using a broad library of enzymes, have 100-fold improved activity against breast, brain, pancreatic, lung and ovarian cancers and ablated associated off-target activity leading to an up to 2.7 × 10(4) fold increase in selectivity.