RESUMO
An indigenous herbal extract IM-133N containing extracts of Prosopis glandulosa Torr and Symplocos racemosa Roxb were evaluated for potential immunomodulatory effects using RAW264.7 and THP-1 cells. The incubation of the cells for 24 h with IM-133N over a dose range 0-125 µg/ml did not cause cytotoxicity that exceeded 10%. The results indicated that non-cytotoxic doses of IM-133N effectively up-regulated iNOS, TNFα, IL-6, IL-10, IL-8 and IFNγ gene expression in both the RAW264.7 and THP-1 cells. The results also indicated IM-133N elicited dose-related increases in nitric oxide (NO) and tumor necrosis factor (TNF)-α production by RAW264.7 or THP-1 cells. These results demonstrated that IM-133N could stimulate NO and induced pro-inflammatory cytokine expression by monocytes/macrophages. As clinical studies have shown IM-133N to be an effective immunomodulator without any adverse effects, the results of the present study provide further support for the potential use of this agent as an immunostimulant or as an immunotherapy adjuvant.
Assuntos
Citocinas/imunologia , Fatores Imunológicos/imunologia , Macrófagos/imunologia , Monócitos/imunologia , Extratos Vegetais/farmacologia , Prosopis/química , Animais , Linhagem Celular Tumoral , Humanos , Fatores Imunológicos/química , Macrófagos/citologia , Camundongos , Monócitos/citologia , Extratos Vegetais/químicaRESUMO
Recent advances in low-power wireless technologies for health are instrumental in bringing EEG monitoring from the hospital to the home environment. This talk provides an overview of imec's research on low-power wireless EEG monitoring. Enabling technologies, integrated systems and remaining challenges are discussed.
Assuntos
Diagnóstico por Computador/instrumentação , Fontes de Energia Elétrica , Eletroencefalografia/instrumentação , Monitorização Ambulatorial/instrumentação , Processamento de Sinais Assistido por Computador/instrumentação , Telemetria/instrumentação , Desenho de Equipamento , Análise de Falha de EquipamentoAssuntos
Ferricianetos/uso terapêutico , Insuficiência Cardíaca/tratamento farmacológico , Nitroprussiato/uso terapêutico , Ensaios Clínicos como Assunto , Insuficiência Cardíaca/fisiopatologia , Hemodinâmica/efeitos dos fármacos , Humanos , Nitroprussiato/efeitos adversos , Respiração/efeitos dos fármacosRESUMO
In this double-blind, placebo-controlled study, treatment of 60 acute hepatitis patients with ribavirin resulted in a more rapid reduction of abnormal laboratory values when compared with the placebo group. Moreover, improved clinical status as reflected by increased appetite with resultant weight gain was noted to be significantly greater in the ribavirin-treated patients. Ribavirin was well tolerated. With this dosage regimen, there were no side effects or changes in laboratory values that could be associated with drug-related toxicity. Since hepatitis A is one of the most common viral infections afflicting the Indian population, the use of a safe and effective therapeutic agent, such as ribavirin, will be necessary to treat these cases.
