[The pulsatile administration of LHRH in the differential diagnosis of hypogonadotropic hypogonadism]. / Administración pulsátil de LHRH en el diagnóstico diferencial de los hipogonadismos hipogonadotróficos.

The results of the pulsating administration of LHRH (APLHRH) using a portable infusion pumps of national fabrication (TECENSA-AIP-GZ) at doses of 18.2 mcq every 90 min., via subcutanea, in abdominal anterior wall are presented. This was carried out in order to localise the hypogonadotropic hypogonadism. There were statistically significant differences between the group of hypothalamic origin and that of hypophyseal origin after the APLHRH administration. In the first group named, the response patterns of LH and FSH were similar to those obtained in adults, while in the second group there was no response. These differences were not observed at basal conditions nor with acute stimuli of LHRH. We concluded, highlighting the efficacy of this test to diagnose the different types of hypogonadotropic hypogonadism.

[The current possibilities in the diagnosis of hypogonadotropic hypogonadism]. / Posibilidades actuales en el diagnóstico de los hipogonadismos hipogonadotróficos.

The diagnosis of hypogonadotropic hypogonadism must be clinically suspected. They produce differential diagnosis problems. The possibilities of diagnosis are reviewed (static hormonal determination, dynamic test-clomiphene test, LHRH acute test, etc.), highlighting the pulsating administration of LHRH which, together with endogenous pulsating of LHRH study (more difficult), are the most useful procedures in differentiating the level of the lesion of hypogonadotropic hypogonadism, as well as differentiating the puberty delayed cases.

[The dynamics of pulsatile LHRH (GnRH) secretion]. / Dinámica de la secreción pulsátil de LHRH (GnRH).

A review of the features of RHLH, especially of the pulsating secretion, which is very important to the correct function of the reproduction system, is presented. Now it is accepted that this pulsating secretion is the producer of the episodic release of gonadotrophins, the gonadal steroids being the modulator of the frequency and the extent of the LHRH pulses. Several experiences showed that changes in the pulse frequency of GnRH, can dynamically modify the seric concentration of LH and FSH.