Assuntos
Fertilização , Poliploidia , Animais , Embrião de Mamíferos/ultraestrutura , Técnicas In Vitro , Cariotipagem , CamundongosAssuntos
Aberrações Cromossômicas/efeitos dos fármacos , Desoxirribonucleases/farmacologia , Divisão Celular/efeitos dos fármacos , Linhagem Celular , Células Cultivadas , Histonas/farmacologia , Humanos , Hidrocortisona/farmacologia , Soluções Hipertônicas , Técnicas In Vitro , Pulmão/embriologia , Sulfato de Magnésio/farmacologia , Pâncreas/enzimologia , Ribonucleases/farmacologiaAssuntos
Divisão Celular , Cromossomos Humanos 16-18 , Cromossomos Humanos 21-22 e Y , Trissomia , Anormalidades Múltiplas/genética , Autorradiografia , Biópsia , Células Cultivadas , Síndrome de Down , Fibroblastos , Humanos , Recém-Nascido , Cariotipagem , Mitose , Pele , Crânio/anormalidades , Síndrome , Timidina , Fatores de Tempo , TrítioRESUMO
Mosaicism of normal and chromosomally aberrant cells was detected in 14 of 20 spleens from adult New Zealand Black (NZB) mice reared under conventional conditions, a strain that spontaneously develops autoimmunity and lymphoreticular malignancy. No abnormalities were found in marrows from these same animals or in spleens from NZB mice younger than 3 months. The prevalence of chromosomal aberrations was significantly higher in spleens from NZB mice than in spleens from the two other strains studied-SJL/J, which has high frequency of reticulum cell neoplasia and paraproteinemia but no autoimmunity, and BALB/c, which has essentially no autoimmunity and only a low incidence of generalized lymphoid neoplasms and plasmacytomas in ageing animals. Causes for the chromosomal abnormalities in NZB mice are considered in terms of other features in these mice-immunoproliferation, autoimmunity, and the presence of murine leukemia ("C"-type) virus particles.
