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J Nat Med ; 67(4): 743-9, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23314829

RESUMO

α,ß-Epoxy-carvone (EC) is a monoterpene found in the essential oils of many species of plants. It can also be obtained by organic synthesis. EC exerts a depressant effect on the central nervous system and is also known to have anticonvulsant, antimicrobial and antioxidant effects. The present study investigated the antinociceptive and anti-inflammatory effects of EC. Intraperitoneal administration of EC at doses of 100, 200 or 300 mg/kg promoted a significant antinociceptive effect, as shown in the acetic acid-induced abdominal writhing test. EC also provoked a reduction in formalin-induced nociception in the first (300 mg/kg) and second phases (200 and 300 mg/kg). In the hot-plate test, an increase in response latency was found at 30 min (at 100, 200 and 300 mg/kg), and at 60 and 120 min (at 300 mg/kg) following administration of EC, an effect that was reversed by naloxone. Intraperitoneal administration of EC (300 mg/kg) inhibited the increased vascular permeability provoked by acetic acid. These findings suggest that EC inhibited the acute inflammatory reaction, with a pronounced peripheral and central antinociceptive effect in mice that is probably associated with activation of the opioidergic system, which appears to play a role in the antinociceptive activity induced by EC.


Assuntos
Analgésicos/farmacologia , Anti-Inflamatórios/farmacologia , Monoterpenos/farmacologia , Ácido Acético/toxicidade , Analgésicos/química , Animais , Anti-Inflamatórios/química , Monoterpenos Cicloexânicos , Formaldeído/toxicidade , Masculino , Camundongos , Monoterpenos/química
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