RESUMO
2-(benzoylamino) pyridinium benzoate (BAPB) has exhibited an antisickling effect with homozygous S/S erythrocytes in vitro. This study suggests that BAPB prevents sickling by inhibiting the gelation of hemoglobin S.
Assuntos
Antidrepanocíticos , Hemoglobina Falciforme , Compostos de Piridínio/farmacologia , Adolescente , Adulto , Eritrócitos Anormais/efeitos dos fármacos , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
The administration of aflatoxin B1 to rats on days 17 and 19 of pregnancy caused increased synthesis of the total lipids and the fatty acids, and decreased synthesis of the phosphatidyl choline in 21-day-old fetal lung. Aflatoxin B1 caused toxicity in the fetal lung as evidenced by the excessive accumulation of the lamellar bodies and the osmiophilic spheroids in the type II cells and the alveolar lumen, respectively. The rearrangement of the lamellar form to the continuous sheet-like tubular myelin form was reduced in the alveolar lumen of the treated lung.
