RESUMO
Space constancy was investigated in seven blindfolded left-neglect patients by driving them along routes involving one or two, left or right, 90 degrees turns. At the end of each route patients had to indicate its starting point while still blindfolded. On average, no considerable left/right differences were found in pointing accuracy. The entailments of this finding for the understanding of neglect phenomena are briefly discussed.
Assuntos
Atenção , Dano Encefálico Crônico/diagnóstico , Dominância Cerebral , Locomoção , Orientação , Percepção Espacial , Adulto , Idoso , Atenção/fisiologia , Dano Encefálico Crônico/fisiopatologia , Dano Encefálico Crônico/psicologia , Mapeamento Encefálico , Córtex Cerebral/fisiopatologia , Percepção de Distância/fisiologia , Dominância Cerebral/fisiologia , Feminino , Humanos , Locomoção/fisiologia , Masculino , Rememoração Mental/fisiologia , Pessoa de Meia-Idade , Testes Neuropsicológicos , Orientação/fisiologia , Resolução de Problemas/fisiologia , Privação Sensorial/fisiologia , Percepção Espacial/fisiologiaRESUMO
The present study concerns the relation between the therapeutic activity of some FANS in formulation for topical use and their lipophylic nature. The efficacy of topic formulations of three widely used FANS: cinnoxicam, piroxicam and diclofenac have been evaluated through the decrease of plantar edema induced by egg's white in the rat's hind paw. The volume increases after one hour were 55% in the group of rats treated with cinnoxicam, 64% in the animals treated with piroxicam and 79% in those treated with diclofenac, against 86% of control group. The partition coefficient (P) of the three active drugs have been detected. The P found for the three drugs 4.9, 3.3, 0.9 respectively demonstrate the direct correlation between the pharmacological activity of the topic formulation and its lipophylic nature.
