Monkeypox Virus: A comprehensive narrative review.

Monkeypox virus, now known as Mpox virus is a large, enveloped, double stranded deoxyribonucleic acid (DNA) virus belonging to the Orthopox viridae genus of the Poxviridae family. Though, Mpox, have earlier been endemic to only African countries, the 2022 outbreak has shown its rapid spread throughout the world. The May 2022 outbreak have shown primarily human to human transmission in contrast to animal to human transmission that had been seen previously. Recent data also suggest a possibility of a pre symptomatic spread. After an incubation period of 9 days, patients with Mpox can present with a prodrome of symptoms followed by a rash. If untreated, severe complications develop in the high-risk groups especially children and pregnant woman. Such groups of people will benefit from antiviral treatments. The current approach to prevent against it is pre-exposure and post exposure prophylaxis with vaccines. The vaccines that have been approved by Food and Drug Administration to date is ACAM2000 and JYNNEOS. Several diagnostic methods exist, among which polymerase chain reaction has proven to be the most specific and sensitive. In this review, we will discuss its epidemiology, the clinical manifestations, diagnostic modalities, complications, treatment approaches and preventive measures.

Comparison of Two Entry Methods for Laparoscopic Port Entry.

Background The first step in laparoscopic surgery is to establish the pneumoperitoneum for which many approaches have been introduced to minimize the complications. Although controversies exist regarding the most efficient technique, till now the best entry technique is still unsettled. Objective To compare the safety, operating time and outcome of Direct Trocar Insertion with a well-established and widely practised Open Access Technique. Method This is a prospective study at Nobel Medical College Teaching Hospital from November 2019 to February 2021. Patients were grouped into either of the two groups, Group 1 for Direct Trocar Insertion and Group 2 for Open Access Technique. They were later analysed for major and minor complications of the technique and a comparison of either method was done at the end of the study period. Result A total of 823 patients were enrolled in the study. Among the study population, 411 patients had Direct Trocar Insertion while 412 patients had Open Access Technique. The majority of the operation that was done during the study period was laparoscopic cholecystectomy. Patients in the Open Access Technique group experienced more complications compared to Direct Trocar Insertion group. Conclusion Despite the fear of adopting the Direct Trocar Insertion, this is a safe, better and quick technique for laparoscopic port entry. However, any surgeon practising laparoscopic surgery should be competent to adopt either technique to overcome failure in either process during port entry.

Toothbrush, an Unusual Foreign Body.

Accidental consumption of foreign body is a common presenting complain among patients especially in young age group. Majority of patients can be discharged safely after reassurance while a fraction of patient requires observation and further management. Here we report a case of a 35-year-old gentleman who presented to the out-patient department of our hospital in June 2021 for accidental ingestion of toothbrush. After detailed history and physical examination upper gastrointestinal endoscopy was planned for the patient. Failed endoscopic removal was considered the indication for surgery. A supraumbilical midline incision was used to remove the toothbrush. Following the surgical removal, he was managed conservatively and was discharged without significant complications. We describe this case in detail in addition to reviewing the pertinent literature.

Clinico-demographic Profile of Poisoning Cases Admitted in Intensive Care Unit of Bharatpur Hospital, A Tertiary Referral Center in Nepal.

Background Poisoning is a major cause of death in young adults. The epidemiological factors such as geography, occupation, literacy rate can influence the clinical presentation and outcome of the poisoning patients. Poisoning has a significant impact on the economic and social life of individuals. Objective The main objective of this study is an effort to evaluate the characteristic of poisoning cases and identify the reasons for Intensive Care Unit (ICU) admission. Method This was a prospective observational study at Bharatpur Hospital ICU over a period of one year. Demographic profiles, poison characteristics, types and reasons for poisoning, duration of hospital stay, and outcome of the patients were studied. Result A total of 156 patients were admitted with poisoning. Females were affected more than males with a ratio of F:M= 1.6:1. The age group that consumed poison the most was 16-25 years, and the mean age group of males was 35±14 years and 29±11 years respectively. The main cause of poisoning was conflicts/quarrel. Organophosphorus compound was the most common poisoning with 53% of total cases due to it. There were 07 cases of accidental poisoning secondary to mushroom poisoning. The mean duration of stay in ICU of these patients was 04 days. The total fatality rate due to poisoning was 07%. Conclusion The significant proportion of Intensive Care Unit admission was due to organophosphorus compounds. It was more common among females and young age groups. This calls for special health education on chemical safety among vulnerable people along with efficient supervision in regulatory controls on chemicals and its use.