RESUMO
This article presents the medical history and management of a 44-year-old Hispanic male with metastatic extra-abdominal gastrointestinal stromal tumor including a literature review on this rare clinical presentation.
Assuntos
Neoplasias Ósseas/secundário , Neoplasias Esofágicas/secundário , Osso Frontal , Tumores do Estroma Gastrointestinal/secundário , Hispânico ou Latino , Adulto , Humanos , MasculinoRESUMO
We report a case of a young female patient presenting with a high serum beta-HCG levels, amenorrhea, nausea and anemia which mimicked pregnancy followed by upper gastrointestinal bleeding. A gastric tumor was shown on endoscopy. Histopathologic evaluation revealed Primary Gastric Choriocarcinoma (PGC). The patient was treated with three cycles of standard nongestational choriocarcinoma chemotherapy. Tumor persistence was evidenced by CT Scans and high serum beta-HCG levels. The patient died approximately six months after diagnosis. Our case report suggest that PGC is a highly aggressive tumor that is often associated with liver and lungs metastasis without evidence of pelvic organ abnormality and is associated with some hormonal effects, such as amenorrhea, anemia, nausea and vomiting mimicking pregnancy in young adult female
Assuntos
Coriocarcinoma não Gestacional/diagnóstico , Erros de Diagnóstico , Neoplasias Gástricas/diagnóstico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Biomarcadores Tumorais/sangue , Bleomicina/administração & dosagem , Coriocarcinoma não Gestacional/tratamento farmacológico , Coriocarcinoma não Gestacional/secundário , Gonadotropina Coriônica Humana Subunidade beta/sangue , Cisplatino/administração & dosagem , Etoposídeo/administração & dosagem , Evolução Fatal , Feminino , Humanos , Ifosfamida/administração & dosagem , Neoplasias Hepáticas/secundário , Neoplasias Pulmonares/secundário , Metotrexato/administração & dosagem , Paclitaxel/administração & dosagem , Gravidez , Gravidez Ectópica/diagnóstico , Terapia de Salvação , Neoplasias Gástricas/tratamento farmacológico , Adulto JovemRESUMO
Paroxysmal nocturnal hemoglobinuria is a rare hematological disorder. It is an uncommon cause of intravascular hemolysis, thrombosis and bone marrow suppression. We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria. The patient responded well to treatment with blood transfusions, steroids and eculizumab. We discuss the underlying pathophysiology, clinical manifestations and treatment of this rare entity.
Assuntos
Hemoglobinúria Paroxística/diagnóstico , Feminino , Doenças Hematológicas , Humanos , Adulto JovemRESUMO
In this report, we describe a patient with Follicular Lymphoma with central nervous system involvement, rarely reported in indolent lymphomas. Central nervous system involvement in indolent non-Hodgkin's lymphoma is a rare and unexpected complication and should be considered in the differential diagnosis of patients presenting with de-novo neurological signs.
