Acoustic Fractional Propagation in Terms of Porous Xerogel and Fractal Parameters.

This article portrays solid xerogel-type materials, based on chitosan, TEGylated phenothiazine, and TEG (tri-ethylene glycol), dotted with a large number of pores, that are effectively represented in their constitutive structure. They were assumed to be fractal geometrical entities and adjudged as such. The acoustic fractional propagation equation in a fractal porous media was successfully applied and solved with the help of Bessel functions. In addition, the fractal character was demonstrated by the produced fractal analysis, and it has been proven on the evaluated scanning electron microscopy (SEM) pictures of porous xerogel compounds. The fractal parameters (more precisely, the fractal dimension), the lacunarity, and the Hurst index were calculated with great accuracy.

AI Evaluation of Imaging Factors in the Evolution of Stage-Treated Metastases Using Gamma Knife.

BACKGROUND: The study investigated whether three deep-learning models, namely, the CNN_model (trained from scratch), the TL_model (transfer learning), and the FT_model (fine-tuning), could predict the early response of brain metastases (BM) to radiosurgery using a minimal pre-processing of the MRI images. The dataset consisted of 19 BM patients who underwent stereotactic-radiosurgery (SRS) within 3 months. The images used included axial fluid-attenuated inversion recovery (FLAIR) sequences and high-resolution contrast-enhanced T1-weighted (CE T1w) sequences from the tumor center. The patients were classified as responders (complete or partial response) or non-responders (stable or progressive disease). METHODS: A total of 2320 images from the regression class and 874 from the progression class were randomly assigned to training, testing, and validation groups. The DL models were trained using the training-group images and labels, and the validation dataset was used to select the best model for classifying the evaluation images as showing regression or progression. RESULTS: Among the 19 patients, 15 were classified as "responders" and 4 as "non-responders". The CNN_model achieved good performance for both classes, showing high precision, recall, and F1-scores. The overall accuracy was 0.98, with an AUC of 0.989. The TL_model performed well in identifying the "progression" class, but could benefit from improved precision, while the "regression" class exhibited high precision, but lower recall. The overall accuracy of the TL_model was 0.92, and the AUC was 0.936. The FT_model showed high recall for "progression", but low precision, and for the "regression" class, it exhibited a high precision, but lower recall. The overall accuracy for the FT_model was 0.83, with an AUC of 0.885. CONCLUSIONS: Among the three models analyzed, the CNN_model, trained from scratch, provided the most accurate predictions of SRS responses for unlearned BM images. This suggests that CNN models could potentially predict SRS prognoses from small datasets. However, further analysis is needed, especially in cases where class imbalances exist.

Mercury Bonding to Xerogel: The Interface Fractal Dynamics of the Interaction between Two Complex Systems.

This study describes novel solid substances founded on chitosan and TEGylated phenothiazine that have a high ability for hydrargyrum recovery from watery liquid solutions. These compounds were taken into account, consisting of two distinct entity interactions inside of the classic fractal dynamics conjecture of an "interface". They were assimilated through fractal-type mathematical objects and judged as such. The bi-stable behavior of two fractally connected objects was demonstrated both numerically and graphically. The fractal character was demonstrated by the fractal analysis made using SEM images of the xerogel compounds with interstitial fixed hydrargyrum. For the first time, SEM helped to verify such samples from two distinct bodies, with the multifractal parameter values being listed in continuation. The fractal dimension of the rectangular mask is D1 = 1.604 ± 0.2798, the fractal dimension of the square mask is D2 = 1.596 ± 0.0460, and the lacunarity is 0.0402.

Fractal Analysis of Four Xerogels Based on TEGylated Phenothiazine and Chitosan.

The present article describes novel massive materials (in the solid phase) based on TEGylated phenothiazine and chitosan that possess great capability to recover mercury ions from constituent aqueous solutions. These were produced by chitosan hydrogelation accompanied by formyl subsidiary item of TEGylated phenothiazine, attended by lyophilization. The delineation and structure description of the obtained material or supramolecular assembly were realized by FTIR (Fourier transform infrared) spectroscopy, X-ray diffraction, and POM (Polarized Light Optical Microscopy). The morphology of their texture was kept under observation by SEM (Scanning Electron Microscopy). The obtained SEM images were evaluated by fractal analysis. The fractal parameters of interest were calculated, including the fractal dimension and lacunarity.

Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of 5-Fluorouracil Release from Chitosan-Based Matrix.

Four medicament delivery formulations based on 5-fluorouracil in a chitosan substantial matrix were realized in situ via 3,7-dimethyl-2,6-octadienal element hydrogelation. Representative samples of the final realized compounds were investigated from an analytic, constitutional, and morphological viewpoint via Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The SEM images of the formulations were investigated in concordance with fractal analysis, and the fractal dimensions and lacunarity were computed. The developed mathematical multifractal model is necessarily confirmed by the experimental measurements corresponding to the 5-fluorouracil release outside the chitosan-formed matrix.

A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix.

A suite of four drug deliverance formulations grounded on 5-fluorouracil enclosed in a chitosan-founded intercellular substance was produced by 3,7-dimethyl-2,6-octadienal with in situ hydrogelation. The formulations have been examined from a morphological and structural point of view by Fourier transform infrared (FTIR) spectroscopy and microscopy with polarized light, respectively. The polarized optical microscopy (POM) pictures of the three representative formulations obtained were investigated by fractal analysis. The fractal dimension and lacunarity of each of them were thus calculated. In this paper, a novel theoretical method for mathematically describing medicament deliverance dynamics in the context of the polymeric medicament constitution limit has been advanced. Assuming that the polymeric drug motion unfolds only on the so-called non-differentiable curves (considered mathematically multifractal curves), it looks like in a one-dimensional hydrodynamic movement within a multifractal formalism, the drug-release physics models are provided by isochronous kinetics, but at a scale of resolution necessarily non-differentiable.

Time Estimation of Polymer Translocation through Nano-Membrane.

In this paper, the charged polymer escapement phenomenon, via a little hole of nano-metric dimensions arranged in a constitutive biological membrane, is studied. We will present the case of the transport process of an ideal polymer in a 3-dimensional extended region separated by a fine boundary named membrane in a free energy barrier attendance. Additionally, the general translocation time formula, respectively, the transition time from the cis area to the trans area, is presented. The model for estimation of the likelihood, designated by P(x, t), as a macromolecular chain of lengthiness equal to x, to be able to pass by the nanopore in escape period t, was optimized. The longest-lasting likely escape time found with this model is indicated to be tp = 330 µs. Thus, the results obtained with the described formula are in good agreement with those announced in the specialized literature.

Polymer Translocation through Nanometer Pores.

In this paper the loaded polymer transport and its escape via a nanometer size aperture, virtually by nanomembrane, the polymer being moved by an exterior electrostatic field, has been studied. Assuming a linear dependency of the friction coefficient on the number of segments m and a parabolic behavior for the open-free (Gibbs) energy, in attendance of a present electrical potential across nanopore, an explicit flux formula for the polymers passed over a dimensional restricted pore, was derived. In addition, the linear polymers transport through a nanometer-sized pore under the action of a constant force is presented. The important mechanical effects of superimposed steady force and the monomers number of macromolecule chain on the polymer translocation process by nanomembranes, in a 2D diffusion model, have been demonstrated. The escape time by a three-dimensional graph as a function of the electric field intensity and monomers number of polymer was represented.

Fractal Modeling of Polymer Plasma Laser Ablation, Plasma Plume Tsallis Entropy and Its q-Statistics Interpretation, Part I: Theory.

Polymer plasma produced by laser ablation is investigated in a theoretical manner. In relation to the fact that the charge carrier circulation is assumed to take place on fractal curves, the so-called fractality type, electrical charge transport can be resolved by an extended scale relativity method. In addition, an elegant mathematical model, utilizing a conjecture of fractal space-time, is elaborated. The complete solution and its graphical representation for temperature distribution in two-dimensional and three-dimensional cases are successfully introduced. The discrete physical behavior and irrevocable transformation of nanoscale microdomain substructures by laser ablation are realistically examined. Further, benefiting from the interpretation of the fractal analysis, each of the experimental results can be fairly explained. On top of that, this paper presents a proof of Tsallis nonextensive q-statistics, especially for the plasma plume studied. Tsallis entropy in direct connection with fractal dynamics and chaotic-type mechanics of the plasma plume and time-series representation of plasma temperature is introduced for the first time in the present publication, and the q-statistics of the plume plasma temperature are also studied, among others.

Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings.

Supramolecular hydrogels based on chitosan and monoaldehydes are biomaterials with high potential for a multitude of bioapplications. This is due to the proper choice of the monoaldehyde that can tune the hydrogel properties for specific practices. In this conceptual framework, the present paper deals with the investigation of a hydrogel as bioabsorbable wound dressing. To this aim, chitosan was cross-linked with 2-formylphenylboronic acid to yield a hydrogel with antimicrobial activity. FTIR, NMR, and POM procedures have characterized the hydrogel from a structural and supramolecular point of view. At the same time, its biocompatibility and antimicrobial properties were also determined in vitro. Furthermore, in order to assess the bioabsorbable character, its biodegradation was investigated in vitro in the presence of lysosome in media of different pH, mimicking the wound exudate at different stages of healing. The biodegradation was monitored by gravimetrical measurements, SEM microscopy and fractal analyses of the images. The fractal dimension values and the lacunarity of SEM pictures were accurately calculated. All these successful investigations led to the conclusion that the tested materials are at the expected high standards.

Fractal analysis in the quantification of medical imaging associated with multiple sclerosis pathology.

BACKGROUNDS: Multiple sclerosis (MS) is an inveterate phlogistic situation characterized by focal and vaguely diffusive de-myelination and neurodegeneration, in the sphere of central nervous system (CNS). The brain's chronic inflammatory reaction includes astrocyte stimulation and microglial motivation, as well as macrophages marginal conscription. This lasting serious soreness of the brain is connected with neurodegeneration period and disability advance. METHODS: The present study is considering two main purposes as follows. Primarily, to apply the fractal analysis in the idea of documenting the fractals dominance at all stages of the nervous system hierarchy, giving faith to the precept of their funciar relevancy. Secondly, to take into account the problems unresolved of the thorough connections between self-organized criticality concept and self-similarity notion. More precisely, in reality we will obtain information about the fractal size and lacunarity of magnetic resonance imaging (MRI), on the areas of interest of the brain, rich in microglial cells with fringes from peripheral macrophages cells. RESULTS: This approach will play a decisive role in the action of detecting neural disabilities, such as in particular multiple sclerosis cortical onset, the final goal of our investigation. The diagnosis is based on interpretation of both histological sample pictures and images obtained by nuclear magnetic resonance. Using fractal analysis, we have calculated, for each image separately, both the fractal dimension and the lacunarity, as an objective quantitative measure of the demyelinating action. CONCLUSIONS: For three histopathological samples on glial cells, with visible erosions, the fractal dimension has value over 1.89 and the lacunarity value is between 0.050 and 0.079. In the gray level stages of the studied MRI pictures, the fractal dimension is above the value of 1.7 and the lacunarity is between the values of 0.0286 and 0.0393.

Electrical Signal Modeling in Cochlear Implants. Study of Temperature and Humidity Effects.

The present paper discusses the climatic effects of humidity and temperature on cochlear implant functioning and the quality of the electrical sound signal. MATLAB Simulink simulations were prepared, offering insights into signal behavior under such climatic parameter changes. A simulation setup of the cochlear implant was developed, where a source type selection was used to change between a voice recording and a "chirp" sound. In addition, a DC blocking filter was applied to the input signal. A simulation code, with the application of the climatic influence via the air attenuation function, was developed. Thereby, the attenuation of temperature and humidity in the sound atmospheric circulation of the input signal, at T = 0 °C and RH = 0% and at T = 36 °C and RH = 40% was graphically represented. The results of the electrical pulse generator for each of the eight channels, with the IIR filter, Gaussian noise, temperature variation, humidity influence, and control of denoise block activity, were thus obtained.

Comparative study on the performance of five different Hall effect devices.

Five different Hall Effect sensors were modeled and their performance evaluated using a three dimensional simulator. The physical structure of the implemented sensors reproduces a certain technological fabrication process. Hall voltage, absolute, current-related, voltage-related and power-related sensitivities were obtained for each sensor. The effect of artificial offset was also investigated for cross-like structures. The simulation procedure guides the designer in choosing the Hall cell optimum shape, dimensions and device polarization conditions that would allow the highest performance.