Validity of fibromyalgia survey questionnaire (2016) assessed by telephone interview and cross-cultural adaptation to Brazilian Portuguese language.

BACKGROUND: To verify the validity of the 2016-revised Fibromyalgia Survey Questionnaire (FSQ) by telephone interview compared to self-administration and to produce a valid version of FSQ in Brazilian Portuguese language. METHODS: The Brazilian version of FSQ was produced following the recommendations for cross-cultural adaptation. Validity of Brazilian FSQ self-administration was assessed by checking agreement of its results with fibromyalgia diagnosis according the 1990 American College of Rheumatology (ACR) criteria. Reproducibility and validity of FSQ by telephone were assessed by comparing its results with the previous FSQ self-administration. RESULTS: A Brazilian Portuguese version (FSQ-Brazil) was produced. FSQ-Brazil had good internal consistency (Cronbach's alpha between 0.73 and 0.94). Agreement between the results obtained by self-administration of FSQ-Brazil and by telephone interview was substantial or almost perfect for almost all questions about pain sites and all questions about other somatic symptoms (Cohen's kappa higher than 0.6). There were small but significant bias toward higher scores of widespread pain index and fibromyalgia severity scale in the telephone interview compared to self-administration. Fibromyalgia definition by self-administration and telephone interview with FSQ-Brazil both revealed substantial agreement with the diagnosis based on ACR 1990 criteria (Cohen's kappa 0.62 and 0.65; respectively). CONCLUSIONS: FSQ-Brazil demonstrated good internal consistency, reproducibility and validity both by self-administration and by telephone interview. However, caution must be taken with the interpretation of quantitative scores of widespread pain index and symptoms severity scale, which slightly differed according the method (self-administration or interview) in our study.

Validity of fibromyalgia survey questionnaire (2016) assessed by telephone interview and cross-cultural adaptation to Brazilian Portuguese language

Abstract Background: To verify the validity of the 2016-revised Fibromyalgia Survey Questionnaire (FSQ) by telephone interview compared to self-administration and to produce a valid version of FSQ in Brazilian Portuguese language. Methods: The Brazilian version of FSQ was produced following the recommendations for cross-cultural adaptation. Validity of Brazilian FSQ self-administration was assessed by checking agreement of its results with fibromyalgia diagnosis according the 1990 American College of Rheumatology (ACR) criteria. Reproducibility and validity of FSQ by telephone were assessed by comparing its results with the previous FSQ self-administration. Results: A Brazilian Portuguese version (FSQ-Brazil) was produced. FSQ-Brazil had good internal consistency (Cronbach's alpha between 0.73 and 0.94). Agreement between the results obtained by self-administration of FSQ-Brazil and by telephone interview was substantial or almost perfect for almost all questions about pain sites and all questions about other somatic symptoms (Cohen's kappa higher than 0.6). There were small but significant bias toward higher scores of widespread pain index and fibromyalgia severity scale in the telephone interview compared to self-administration. Fibromyalgia definition by self-administration and telephone interview with FSQ-Brazil both revealed substantial agreement with the diagnosis based on ACR 1990 criteria (Cohen's kappa 0.62 and 0.65; respectively). Conclusions: FSQ-Brazil demonstrated good internal consistency, reproducibility and validity both by self-administration and by telephone interview. However, caution must be taken with the interpretation of quantitative scores of widespread pain index and symptoms severity scale, which slightly differed according the method (self-administration or interview) in our study.(AU)

Avaliação da microarquitetura e resistência óssea por tomografia computadoriazada quantitativa periférica de alta resolução (HR-pQCT) em pacientes com lúpus eritematoso sistêmico de início juvenil / Bone impairment assessed using high resolution peripheral quantitative computed tomography (HR-pQCT) in juvenile-onset systemic lupus erythematosus

Objetivo: Avaliar por HR-pQCT a densidade mineral óssea volumétrica (vDMO), a microarquitetura e as características biomecânicas do rádio distal e tíbia, assim como os marcadores laboratoriais do metabolismo ósseo em pacientes com lúpus eritematoso sistêmico de início juvenil (LESJ) comparados com controles saudáveis e determinar se este método permite identificar parâmetros que diferenciem pacientes com e sem fraturas vertebrais (FV). Métodos: Foram avaliadas 56 pacientes e comparadas a 56 controles saudáveis pareados por sexo, idade e estágio de Tanner. A HRpQCT foi realizada no rádio distal e na tíbia. Marcadores bioquímicos do metabolismo ósseo foram avaliados: pró-peptídeo amino-terminal do colágeno tipo I (P1NP), telo-peptídeo carboxi-terminal do colágeno tipo I (CTX), paratormônio intacto (iPTH), esclerostina (SOST) e 25hidroxivitamina D (25OHD). Fratura vertebral foi avaliada por VFA-DXA (método semiquantitativo de Genant). Resultados: Redução na densidade volumétrica e na resistência óssea, assim como comprometimento da microarquitetura óssea tanto cortical como trabecular foram encontrados em pacientes com LESJ comparados com controles saudáveis, principalmente no rádio distal (p < 0.05). Além disso, pacientes com FV apresentavam valores significantemente menores nos parâmetros trabeculares, somente no rádio distal, comparados com pacientes sem FV (Total.DMO: 229,45 ± 42,09 vs 275,93 ± 56,87 mg/cm3; p = 0,034; Trabecular.DMO [Tb.DMO]: 136,96 ± 30,84 vs 163,17 ± 30,45 mg/cm3; p = 0,034; BV/TV: 0,114 ± 0,026 vs 0,136 ± 0,029; p = 0,034) e também menores valores em relação a propriedades biomecânicas (Módulo Aparente: 1236 ± 334 vs 1523 ± 367 N/mm2; p = 0,039). Pacientes com fratura vertebral apresentaram maiores índices de SLICC/ACR-DI (0,67 ± 0,78 vs 0,11 ± 0,32; p = 0,002). Parâmetros laboratoriais do metabolismo ósseo foram semelhantes entre os grupos avaliados. Análise de regressão logística incluindo parâmetros que foram...

Objective: The aim of this study was to investigate using HR-pQCT the volumetric bone mineral density (vBMD), microarchitecture and biomechanical features at distal radius and tibia, and laboratory bone markers in JoSLE patients compared to controls and determine whether this method can discriminate JoSLE patients with or without VF. Methods: We compared 56 female JoSLE patients with age- and Tanner- matched healthy controls. HR-pQCT was performed at distal radius and at tibia. Serum levels of amino-terminal pro-peptide of type I collagen (P1NP), C-terminal telopeptide of type I collagen (CTX), intact parathormone (iPTH), sclerostin (SOST) and 25 hydroxivitamin D (25OHD) were evaluated. Vertebral fractures (VF) were analyzed by VFA-DXA (Genant's method). Results: Reduced parameters of density and strength as well as microarchitecture alteration of cortical and trabecular bone were observed in JoSLE patients compared to controls, mainly at distal radius (p < 0.05). In addition, patients with VF had a significant decrease in trabecular bone parameters solely at distal radius (Total.BMD: 229.45 ± 42.09 vs. 275.93 ± 56.87 mg/cm3; p = 0.034; Trabecular.BMD[Tb.BMD]: 136.96 ± 30.84 vs. 163.17 ± 30.45 mg/cm3; p = 0.034; BV/TV: 0.114 ± 0.026 vs. 0.136 ± 0.29; p=0.034; Apparent modulus: 1,236 ± 334 vs. 1,523 ± 367 N/mm2; p = 0.039) and higher score disease damage (SLICC/ACR-DI: 0.67 ± 0.78 vs. 0.11 ± 0.32; p = 0.002). Bone metabolism markers were alike in all groups evaluated. Logistic regression analysis including parameters that were significant at univariate analysis reveal that Tb.BMD (OR:0.98, 95%CI 0.95-0.99, p = 0.039) and SLICC/ACR-DI (OR:7.37, 95%CI 1.75-30.97, p=0.006) were independent risk factors for vertebral fractures. Conclusion: In conclusion, this is the first demonstration of bone microstructure and strength deficit in JoSLE patients, particularly at distal radius. Furthermore, our results show that VF are associated with trabecular...

Good clinical response to methotrexate treatment in a patient with fibroblastic rheumatism.

Fibroblastic rheumatism (FR) is a rare disease first described by Chaouat (in Rev Rhum Mal Osteoartic 47:345-351, 1980) and is characterized by a combination of rheumatologic and dermatological manifestations. Rheumatologic features are symmetrical polyarthralgias with joint stiffness, associated with cutaneous nodules and sclerodactyly. Histology shows an increased number of fibroblasts and a marked dermal fibrosis. A large number of treatments have been tried, but all of them have shown an unpredictable effect on FR. We report a Brazilian case of FR showing a good clinical response to methotrexate treatment. This drug may be considered an effective treatment in FR.