1.
Biol Psychiatry
; 20(10): 1090-7, 1985 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3899198
RESUMO
Fenfluramine (Fen) 40 mg, a selective releaser of serotonin, and dextroamphetamine (Dex) 15 mg were administered in a double-blind crossover design to 16 subjects with major affective disorder, depression. Three hours after administration both drugs significantly improved depression and improved vigor, fatigue, and confusion-bewilderment on the subscales of the Profile of Mood States. Dex was significantly better than Fen only on the vigor and fatigue subscales. Other data from this study suggest that when used acutely Fen can mimic long-term antidepressant effects, whereas the acute effects of Dex are similar to its stimulating effects in normals.
Assuntos
Transtorno Depressivo/tratamento farmacológico , Dextroanfetamina/uso terapêutico , Fenfluramina/uso terapêutico , Adulto , Idoso , Ensaios Clínicos como Assunto , Transtorno Depressivo/psicologia , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Norepinefrina/sangue , Testes Psicológicos , Serotonina/sangue
2.
Ann Intern Med
; 91(5): 795, 1979 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-496130
3.
Ann Intern Med
; 90(2): 276-7, 1979 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-443673