[Dynamics of free-radical oxidation indices in blood of dogs with different radiosensitivity level].

The parameters of free radical oxidation of dog's blood irradiated by protons in lethal doses (130-370 Gy) were investigated. The reliable differences of luminescence dynamics in radiosensitive and radioresistant animals were noted. It was concluded that the chemiluminescence responce on local irradiation of brain zone differs considerably from such in case of total animal irradiation.

[The prediction of individual radiosensitivity by the indices of blood chemiluminescence in intact animals]. / Prohnozuvannia indyvidual'noï radiochutlyvosti za deiakymy pokaznykamy khemiliuminestsentsiï krovi intaktnykh tvaryn.

The possibility of prediction of individual radiosensitivity by the chemiluminescence test is considered in this paper. Chemiluminescence is the phenomena which reflects a lot of biochemical processes connected indirectly with radiosensitivity. It has been established that dependence of the animal mortality on the value of the knmax/knmin ratio (kn coefficients of free-radical reaction rates) is of the parabolic shape. This agrees with available data that animals with extreme deviations of homoeostasis characteristics from average values are more susceptible to radiation than animals with characteristics close to average ones. Thus, the characteristics k1, k2 and k3 can be recommended as the determinants when predicting the radiation injury result.

[Correlation of chemiluminescent parameters of blood in non-irradiated animals with their survival after irradiation]. / Koreliatsiia pokaznykiv khemiliuminestsentsii krovi u neoprominenykh tvaryn z chasom tryvannia ikh zhyttia pislia oprominennia.

Blood chemiluminescence is a reflection of the free radical oxidation process in every organism. The changes of its intensity, as a consequence of changes in the rate of this process, are connected, in its turn, with the changes, in the functional state of the organism. It is supposed that the differences in the radiosensitivity depend on the conditions in which free radical oxidation processes take place. Therefore, the indices of blood chemiluminescence of intact rats have been studied. The aim of the investigation is to find the correlations between these indices and the survival of animals irradiated with gamma-quantas in doses of 3.5, 7.0 and 9.0 Gr. It is established that the coefficients of the reaction rate (k1, k2 and k3) most reliably correlate with survival, whereas no correlation is observed between the other indices of chemiluminescence and survival.

[Circadian and seasonal rhythms in the radiosensitivity of mongrel white rats]. / Sutochnye i sezonnye ritmy radiochuvstvitel'nosti belykh besporodnykh krys.

From experiments in albino mongrel rats it is shown that the radiosensitivity of gamma-irradiated (60Co) animals follows a daily rhythm. A synchronization of the daily rhythms in radiosensitivity was noted in winter and during the first spring month which was impaired in April. Established were the rhythms of radiosensitivity for three seasons, i. e. winter, spring and summer, with the extremes in the dependence upon mean annual values varying significantly.