Better off alone? Comparing the substance use, mental health and trauma risks of youth alcohol and other drug service users either living in out of home care, living with parents or experiencing homelessness.

INTRODUCTION: All young people seeking assistance from youth alcohol and other drug services require support to help them minimise the harms from their substance use and continue to develop healthy and meaningful lives. A particular focus on young people in residential out of home care (OoHC) highlights the increased risks of substance use, mental health issues and continued vulnerabilities in this group. While in the past, research contrasted this group with young people living at home, this study contrasted young people in OoHC with homeless youths alongside those living with parents. METHODS: The research contrasted these three groups of young people on substance use profiles, mental health and wellbeing and vulnerability to abuse (historic and current) in the Youth Needs Census conducted in Victoria and Queensland over 2013-2017. RESULTS: The results demonstrate a clear risk of increased casual and daily methamphetamine use in the homeless youth group and occasional heroin use in the OoHC group. Mental health measures for both the OoHC and homeless youths were worse than the young people living at home. Trauma was similarly higher in these groups, with both historical and ongoing risks of violent crime for homeless youths. DISCUSSION AND CONCLUSIONS: The results demonstrate the similar and serious health and wellbeing risks facing both youths in residential OoHC and homeless youths. These results are concerning as one of these groups is ostensibly in the care of the community and government, while the other group is experiencing unstable accommodation and associated physical risks.

Which behaviours? Identifying the most common and burdensome behaviour changes in amyotrophic lateral sclerosis.

Behaviour change is increasingly recognised as a common feature of amyotrophic lateral sclerosis (ALS), and may be similar to that seen in frontotemporal dementia (FTD). The behaviours most disturbed in ALS, and those that relate most significantly to caregiver burden, however, have not been well established. Forty ALS participants and their caregivers, and 27 age- and gender-matched healthy controls and their relatives, participated in this study. ALS participants were assessed on a disease rating scale, and caregivers and control informants completed the revised version of the Cambridge Behaviour Inventory and a measure of burden. ALS caregivers reported significantly more disturbance than healthy control informants on the functional domains of everyday skills, self-care, and sleep, and in the behavioural domains of mood and motivation. There were no differences between groups in frequency of memory and orientation difficulties, or behaviours characteristic of FTD, such as changes to eating habits or stereotypic and motor behaviour, indicating that the behavioural profile in ALS may differ from FTD. In the ALS group, the domains with the strongest relationship to caregiver burden were everyday skills, motivation and memory, likely because poor motivation, memory dysfunction and difficulties completing activities of daily living require more carer support via direct supervision, prompting or hands on care. Services to support ALS patients and caregivers need to provide targeted interventions for those functional and behavioural changes which are most burdensome in the disease.

Comparing neurocognition in severe chronic schizophrenia and frontotemporal dementia.

OBJECTIVE: Previous research has suggested cognitive similarities between schizophrenia and frontotemporal dementia. In the current study, we compared neurocognition in a group of hospitalised patients with chronic schizophrenia, who may have a more severe form of schizophrenia resembling Emil Kraepelin's dementia praecox, with patients with frontotemporal dementia. We hypothesised minimal group differences in cognitive performance, and a large overlap in between-group score distributions in each cognitive domain. METHODS: Retrospective neuropsychological data for 26 patients with severe chronic schizophrenia and 34 patients with frontotemporal dementia (behavioural variant) was collated. Neuropsychological measures were categorised into 16 cognitive domains. Raw scores were converted into standardised z-scores for each measure, which were then averaged across measures within each domain. In addition to difference analysis, equivalence testing was utilised, whereby overlap percentages were computed to reflect the amount of score distribution overlap in each domain between groups. RESULTS: A statistically significant difference was observed only in the executive function sub-domain of Switching. Small-to-moderate and moderate effect sizes were noted in four other domains. Equivalence testing showed more than 85% of overlap in score distribution in most domains. CONCLUSIONS: Our findings suggest that some patients with severe chronic schizophrenia have cognitive deficits similar in degree and pattern to patients with frontotemporal dementia. The few differences observed between both groups of patients are important for differential diagnostic purposes. One limitation is the retrospective nature of the study. Suggestions for future research include longitudinal follow-up studies of these two patient populations and studies of aspects beyond neurocognition. An implication of our findings is that the 'dementia of schizophrenia' concept may be applicable to patients with severe chronic schizophrenia.

Temporal dissociation between distractors and targets: the impact of residual distractor processing on target responses.

The authors manipulated the extent of distractor interference with learned, mapped responses by presenting distractors to participants (N = 16) before, simultaneously with, or after the target. Interference was significantly less when the distractor preceded the target's presentation by 200 ms than when distractor and target were presented simultaneously. Interference decreased progressively with increasing intervals. For both simultaneous and temporally separated distractor-target presentations, incongruent distractors were associated with the greatest interference, and neutral and congruent distractors interfered to a lesser degree. Distractors at fixation had a crucially greater impact on goal-directed responses to the target than did distractors at periphery. The authors discuss the findings in the context of (a) the time course of the processing of all inputs, (b) the subsequent enhancement of target-related information and responses, and (c) the inhibition of distractor-related information and responses.

The impact of Degraded distractors on (Nondegraded) target identification.

In this series of experiments, based on Biederman's Recognition by Components theory, we postulate that corners (vertices) of objects are crucial in programming and execution of goal-directed action. We used a distractor interference paradigm to present line drawings of letters (M and W) with distractors (also M and W), which were either nondegraded or degraded (that is, corners or line segments missing). Degraded distractors caused less interference overall (reduced response times and errors) than Nondegraded distractors, when these were presented peripherally or at fixation (Experiments 1 and 2). When presented at fixation, however, distractors with corners missing caused greater interference than distractors with line segments missing. This pattern was not replicated with non-identical, non-mirror reversed stimuli (H and E: Experiment 3). We speculate that corners are critical in determining the extent of distractor interference. When missing from view, and given sufficient attentional resources and structural similarity, they may be reconstructed by the visuomotor system to aid performance to the target.