[Liver sinusoidal cells: nature, functional characteristics, and cooperative relationships]. / Sinusoidal'nye kletki pecheni: priroda, funktsional'naia kharakteristika i kooperativnaia vzaimosviaz'.

Morphological and functional features as well as cooperative relations of Kupffer's cells, endotheliocytes, lipocytes and pit-cells under normal and pathological conditions delineated in the literature are reviewed. It is shown that liver sinusoid cells protect the parenchyma, control hepatocyte regeneration, take part in the antitumor immunity, participate in the metabolism of lipids, lipoproteins, proteins, biogenic amines and collagen while the cooperative interaction between them and hepatocytes determines an interhepatic homeostasis.

[Evaluation of therapeutic effectiveness of prednisolone in patients with chronic active hepatitis based on the morphometry of liver biopsy specimens]. / Otsenka terapevticheskoi effektivnosti prednizolona u bol'nykh khronicheskim aktivnym gepatitom po dannym morfometrii bioptatov pecheni.

In 42 patients with chronic active hepatitis (CAH), liver biopsies were subjected to histological study and morphometry before and after prednisolone treatment (21 patients comprising group I) and treatment with a complex of vitamins B1, B6, B12 and C (21 patients comprising group II). Combined study of liver biopsies during treatment makes it possible to evaluate objectively enough the results of prednisolone therapy of CAH patients. The authors confirmed the efficacy of prednisolone therapy of patients with sero-negative CAH. These patients demonstrated a reduction in dystrophic alterations, volume of inflammatory cells in the portal tracts and in the areas of necrosis, a lowering of the number of aggressive lymphocytes. Prednisolone was discovered to have an adverse effect on seropositive CAH, to activate virus replication in liver tissue, intensify necrotic alterations in the parenchyma and inflammatory reaction in the portal tracts.