[Disseminated intravascular coagulation syndrome (DIC) in stomach and intestinal cancer]. / Sindrom disseminirovannoi vnutrisosudistoi svertyvaemosti (DVS) pri rake zheludka i kishechnika.

Hemostasis was studied in 70 patients with gastric or intestinal cancer. Pronounced imbalance in blood coagulation was established, resulting in chronic disseminated intravascular coagulation (DIC) syndrome in 55.7 and thrombophilia--in 20% of cases. Advancement of tumor to stage IV was followed by development of stage II (subacute) DIC syndrome. The syndrome was frequently manifested by thrombohemorrhagic complications which occurred in 14.5% of cancer patients (autopsy data). It was inferred that timely treatment of malignancies, early administration of heparin, fibrinolysis--activating drugs and deaggregants are pathogenetically justified means for prevention and treatment of DIC syndrome.

[Disorders of hemostasis in peptic ulcer of the stomach and duodenum]. / Narusheniia gemostaza pri iazvennoi bolezni zheludka i dvenadtsatiperstnoi kishki.

Eighty-seven patients with complicated patterns of peptic ulcer were examined for different components of the hemostatic system including gastric and duodenal fibrinolysis. It was established that the penetrating ulcer gives rise to hypocoagulemia and accelerates fibrinolysis. The perforating and hemorrhagic ulcers are associated with hypercoagulation, which is a manifestation of the stress response of the body. It is shown that gastric juice and the duodenal content have a hypocoagulation (heparinoid) action on blood and plasma coagulation. Peptic ulcer is marked by high gastric and duodenal fibrinolysis and proteolysis both in the gastric and duodenal mucosa and in the free gastric and duodenal contents as well. It is postulated that all the factors under consideration, which are unfavourable for local hemostasis, may be involved in the pathogenesis of gastroduodenal hemorrhages. The author holds that hemostatics, which suppress fibrinolysis and the acid-peptic factor and stimulate blood coagulation and clot formation in the zone of hemorrhage, may be used locally.

[Treatment of profuse gastroduodenal hemorrhages in peptic ulcer and myocardial infarction]. / Lechenie profuznykh iazvennykh gastroduodenal'nykh krovotechenii pri infarkte miokarda.

Results of the treatment of 7 patients with gastroduodenal hemorrhage in acute myocardial infarction have shown that urgent operative treatment is indicated after inefficient concentrative hemostatic therapy within 3--6 hours or in recurrent hemorrhages.