Assuntos
Serviços de Saúde Comunitária/organização & administração , Infecções por HIV/terapia , HIV-1 , Planejamento de Assistência ao Paciente/organização & administração , Adulto , Serviços de Saúde Comunitária/economia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Planejamento de Assistência ao Paciente/economia , VirginiaRESUMO
In a sample of 228 Framingham Study participants aged 58 to 86 who were typed for HLA, neither frequencies of individual antigens nor heterozygosity at the A or B loci appeared to be related to age. Previously found associations could be chance occurrences, or HLA-related effects on longevity in the general population might be small. It is also possible that such effects occur at younger ages than those included in our study or that HLA is related to the aging process in a way that is detectable only at very advanced ages.
Assuntos
Envelhecimento , Antígenos HLA/genética , Idoso , Genética Populacional , Antígeno HLA-A1 , Antígenos HLA-B , Antígeno HLA-B40 , Heterozigoto , Humanos , Massachusetts , Pessoa de Meia-IdadeRESUMO
In a population-based study of herpesvirus infection and human leukocyte antigen (HLA) phenotype, conducted during the period 1977-1979 in the Framingham Study cohort, HLA-Bw16 was found less often and HLA-Cw2 more often in individuals with histories of herpes labialis than in other individuals. Similarly, both geometric mean antibody titer to herpes simplex type 1 and proportion of individuals with detectable antibody were higher in those without Bw16 and in those with Cw2. No strong association was found between HLA and history of herpes zoster or titer to herpes simplex type 2, varicella-zoster virus or cytomegalovirus.
