Pregnancy After Amputation: A Systematic Review of Pregnancy Experiences for Women With Lower Extremity Amputations.

ABSTRACT: Pregnancy could affect the mobility of women with lower extremity limb loss, deficiency, or amputations. The aim of this systematic review was to characterize the pregnancy-related experiences, including prosthesis, gait aid, and mobility outcomes, of women with lower extremity limb loss, deficiency, or amputations. MEDLINE, CINAHL, and Embase databases were searched for all relevant English-language articles describing pregnancy experiences of women with lower extremity limb loss, deficiency, or amputations. Data extracted were age, amputation level and etiology, obstetrical history, prosthesis and/or gait aid use before, during, and after pregnancy, and pregnancy-related complications. Risk of bias was assessed using applicable CLARITY tools. Data were analyzed with descriptive statistics. Among 399 retrieved studies, 24 met inclusion criteria describing 31 pregnancies in 25 women. All were case series/reports with high risk of bias. All women had acquired lower extremity limb loss, deficiency, or amputations. Sixteen women had hemipelvectomy (64%) and 4 had transfemoral amputations (16%). Three women used a prosthesis, 5 did not, and use was not described for 17 (68%). Prosthesis or gait aid use changed in 2 pregnancies, did not change in 6, and was not specified in 23 (74%). Available cases are likely not representative; additional research is required to characterize the impact of pregnancy on women with lower extremity limb loss, deficiency, or amputations.

Walking while talking: validation in older adults with lower-limb amputation.

BACKGROUND: Walking while talking (WWT) is a dual-task (cognitive and motor) performance test that has not yet been validated in older adults with lower-limb amputation (LLA). WWT is composed of two sections: WWT-simple (walking while reciting every letter of the alphabet) and WWT-complex (walking while reciting every other letter of the alphabet). OBJECTIVE: To determine the validity, and provide normative data and a new scoring system for the WWT test in older adults with LLA. STUDY DESIGN: Baseline cross-sectional data were collected from 56 community-living older adults (≥50 years old) with LLA at rehabilitation hospitals in Vancouver, BC, London, ON, and Edmonton, AB, Canada. METHODS: Time and number of recited letters and errors during both sections were recorded. A new score was developed based on all these variables. Correlations of the recorded times with the Activities-specific Balance Confidence (ABC) scale and the 2-Minute Walk Test (2MWT) score were used to evaluate the validity of the WWT test. RESULTS: As hypothesized, the times for both sections of the WWT were negatively correlated with both the ABC and 2MWT scores. Positive correlations were observed between the scores developed for both WWT sections with the 2MWT score. CONCLUSION: Times taken to complete each section of the WWT test were correlated with the 2MWT and the ABC scale scores, providing evidence for the validity of the WWT test. We also provided a scoring method that is more objective and in line with the dual-task nature of the test.

Rehabilitation outcomes after major lower limb amputation in the oldest old: a systematic review.

BACKGROUND: Because the population grows older and the burden of chronic disease increases, many individuals will undergo major lower limb amputation (LLA) at advanced ages. There is a scarcity of literature focusing on the outcomes of rehabilitation for people who acquire LLA at 80 years of age and older. OBJECTIVES: To determine the scope of empirical evidence regarding prosthetic rehabilitation for newly acquired LLA in the oldest old (≥80 years of age). STUDY DESIGN: Systematic Review. METHODS: The databases CINAHL, EMBASE, MEDLINE, and Scopus were searched from inception through June 6, 2020 (PROSPERO: #CRD 42020188623). Two authors independently reviewed all titles and abstracts for inclusion. Inclusion criteria, LLA of any etiology at the transtibial level or above, those who were ≥80 years of age at the time of amputation, and had rehabilitation outcomes reported. RESULTS: Of 11,738 articles identified from databases, 117 underwent full-text review and 10 met inclusion criteria. Multiple rehabilitation outcomes were assessed by the selected studies, including general outcomes, prosthetic-related outcomes, and functional abilities. Individuals ≥80 years of age were able to successfully use a prosthesis, discharged home, and performed activities independently or with support. However, increased age was negatively associated with prosthesis fitting and rehabilitation success was not uniform in some participants. CONCLUSIONS: The oldest old with major LLA can be successful in prosthetic rehabilitation. Age alone should not disqualify individuals from assessment or participation in an amputee rehabilitation program. More research is needed to better understand the rehabilitation outcomes in this population of people with LLA.

Validity of measures for life space mobility and physical activity in older adults with lower-limb amputation.

BACKGROUND: Older adults with lower-limb amputations (LLAs) often experience lack of confidence and poor balance, which limits their mobility. There are few validated measures for assessing these outcomes in the LLA population. OBJECTIVES: To assess the validity of the Life Space Assessment (LSA) and the Physical Activity Scale for the Elderly (PASE) for older adults with LLA. STUDY DESIGN: Secondary analyses of cross-sectional data. METHODS: Sixty-eight older adults with LLA across Canada were recruited to complete the LSA and the PASE. Validity was assessed via correlations with the Activities-specific Balance Confidence (ABC), Four-Square Step Test (FSST), and Two-Minute Walk Test (2-MWT). RESULTS: As hypothesized, the LSA was positively correlated with the ABC (ρ = 0.36, 95% confidence interval [CI] [0.17, 0.62]) and 2-MWT (r = 0.49, 95% CI [0.27, 0.70]) and negatively correlated with FSST (ρ = -0.39, 95% CI [-0.56, -0.10]). The PASE was positively correlated with the ABC (ρ = 0.34, 95% CI [0.10, 0.56]) and 2-MWT (ρ = 0.32, 95% CI [0.05, 0.52]), and negatively correlated with FSST (ρ = -0.36, 95% CI [-0.53, -0.07]). CONCLUSIONS: The LSA has validity in measuring life space mobility. The PASE captures the physical activity with weaker support of validity in older adults with LLA. CLINICAL RELEVANCE: The LSA and PASE are quick low-cost tools for clinicians to assess mobility-related functional health and physical activity, respectively, in older adults with LLA. However, the PASE may contain activities that are not common among older adults with LLA.

Potential of Timed 25-Foot Walk Values in Predicting Maximum Walking Distance in Persons with Multiple Sclerosis.

BACKGROUND: Expanded Disability Status Scale (EDSS) scores of 4.0 or greater are determined primarily by maximum walking distance (MWD). Estimation of MWD by persons with multiple sclerosis (MS) is often used due to the impracticality of formally walking a person with MS in a clinic setting. Previous studies have demonstrated discrepancies between estimated and actual MWDs. Whether Timed 25-Foot Walk test (T25FW) values can be used to predict MWD is currently unknown. This study aimed to determine whether T25FW time is predictive of MWD in persons with MS. METHODS: This study is a post hoc analysis of a previously described prospective cohort study. Persons with MS with an EDSS score of 3.5 to 5.5 were included. The participant's T25FW values and MWD were measured. RESULTS: Of the 38 adult participants (mean age, 50.8 years; 27 women [71%]), 24 (63%) had relapsing-remitting MS. The median EDSS score was 4.5 (range, 3.5-5.5). The T25FW times were divided into seven categories (<5.0, 5.0-5.9, 6.0-6.9, 7.0-7.9, 8.0-8.9, 9.0-9.9, and ≥10.0 seconds). The MWDs were divided into corresponding EDSS score categories: ≥500, 300-499, 200-299, 100-199, and ≤99 m. Ordinal logistic regression, when controlled for age, found the T25FW categories to be predictive of EDSS score (χ2 = 17.630, df = 7, P = .014). CONCLUSIONS: The T25FW value may be used as a surrogate estimate of MWD. Further studies are needed to confirm the reliability of the T25FW in predicting MWD.

Risk Factors for Falls in Individuals With Lower Extremity Amputations During the Pre-Prosthetic Phase: A Retrospective Cohort Study.

BACKGROUND: Falls in individuals with lower limb amputations (LLAs) pose significant health concerns. The literature is limited regarding falls during the preprosthetic phase of rehabilitation for persons with LLAs. OBJECTIVE: To determine the incidence of falls and identify factors associated with falls during the preprosthetic recovery phase. DESIGN: Retrospective chart audit. SETTING: Inpatient rehabilitation program. PARTICIPANTS: Four hundred forty individuals with LLAs (age ± SD = 61.93 ± 14.53 years, 73.18% male) who attended inpatient rehabilitation from 26 July 2011 to 21 August 2017. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASUREMENTS: The number of self-reported falls was recorded from the time of surgery to admission for inpatient rehabilitation. Outcomes of interest were any fall (1+ fall) and recurrent falls (2+ falls). A retrospective chart audit was performed on consecutive admissions to an inpatient rehabilitation program. RESULTS: The incidence of falls was 8.37 per 1000 patient-days. Falls were sustained by 60.9% of the sample. Unilateral transtibial amputation was independently associated with an increased risk of recurrent falls (relative risk [RR] 1.59, 95% confidence interval [CI] 1.13-2.23, P = .008). Diabetes mellitus was independently associated with an increased risk of any fall (RR 1.18, 95% CI 1.01-.38, P = .03). Finally, bilateral transtibial amputation was independently associated with a reduced risk of any fall (RR 0.59, 95% CI 0.39-0.90, P = .014). CONCLUSIONS: Consistent with the current literature, diabetes mellitus and a unilateral transtibial amputation were risk factors for falling, whereas a bilateral transtibial amputation and increasing age presented new findings as factors associated with decreased falling. LEVEL OF EVIDENCE: III.

Relationship between body image and physical functioning following rehabilitation for lower-limb amputation.

The aim of the present study was to evaluate change in body image and the association between body image at discharge and mobility 4 months after rehabilitation. A prospective cohort comprising adults older than or equal to 50 years of age undergoing rehabilitation for first major lower-limb amputation at an inpatient prosthetic rehabilitation program were assessed at discharge and 4 months after rehabilitation. Paired t-tests compared total Amputee Body Image Scale (ABIS), gait velocity, and L-test scores between discharge (T1) and 4 months (T2). Multivariable linear regression assessed relationship between ABIS scores and mobility. Nineteen participants completed assessments (mean±SD age=60.86±6.85 years; 63.20% male patients). Body image changed from T1 (43.58±7.83) to T2 (48.26±12.21), but was not statistically significant (P=0.063). Mobility significantly improved at T2. ABIS scores at T1 were not associated with mobility at T2. Mobility improved after discharge but was not related to body image at T1. Additional research on the impact of body image perception on patient outcomes after rehabilitation is needed.

Comparing the Effects of Dual-Task Gait Testing in New and Established Ambulators With Lower Extremity Amputations.

BACKGROUND: Gait is a complex process that involves coordinating motor and sensory systems through higher-order cognitive processes. Walking with a prosthesis after lower extremity amputation challenges these processes. However, the factors that influence the cognitive-motor interaction in gait among lower extremity amputees has not been evaluated. To assess the interaction of cognition and mobility, individuals must be evaluated using the dual-task paradigm. OBJECTIVE: To investigate the effect of etiology and time with prosthesis on dual-task performance in those with lower extremity amputations. DESIGN: Cross-sectional study. SETTING: Outpatient and inpatient amputee clinics at an academic rehabilitation hospital. PARTICIPANTS: Sixty-four individuals (aged 58.20±12.27 years; 74.5% male) were stratified into 3 groups; 1 group of new prosthetic ambulators with transtibial amputations (NewPA) and 2 groups of established ambulators: transtibial amputations of vascular etiology (TTA-vas), transtibial amputations of nonvascular etiology (TTA-nonvas). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Time to complete the L Test measured functional mobility under single and dual-task conditions. A serial arithmetic task (subtraction by 3s) was paired with the L Test to create the dual-task test condition. Single-task performance on the cognitive arithmetic task was also recorded. Dual-task costs (DTCs) were calculated for performance on the cognitive and gait tasks. Analysis of variance determined differences between groups. A performance-resource operating characteristic (POC) graph was used to graphically display DTCs. RESULTS: Gait performance was worse under dual-task conditions for all groups. Gait was significantly slower under dual-task conditions for the TTA-vas (P < .001), TTA-nonvas (P < .001), and NewPA groups (P < .001). However, there was no between-group difference for gait DTC. The 3 groups tested did not differ in the amount of cognitive DTC (DTCcog). Dual-task conditions also had a negative impact on cognitive task performance for the TTA-nonvas (P = .02) and NewPA groups (P < .001). The TTA-vas group had a slight improvement during dual-task conditions and has a positive DTCcog as a result (P = .04). However, no between-group differences were seen for DTCcog. The POC graph demonstrated that many individuals had a decrease in performance on both tasks; however, the gait task was prioritized for the majority (56.2%) of participants. CONCLUSIONS: Cognitive distractions while walking pose challenges to individuals regardless of etiology, level of amputation, or time with the prosthesis. These findings highlight that individuals are at risk for adverse events when performing multiple tasks while walking. LEVEL OF EVIDENCE: II.

Dual-task related gait changes in individuals with trans-tibial lower extremity amputation.

BACKGROUND: The improvement of gait and mobility are major rehabilitation goals following lower extremity amputations. However, when living in the community many daily activities require the multitasking of motor and cognitive tasks. The dual-task paradigm can be used to evaluate the concurrent performance of mobility and cognitive tasks. RESEARCH QUESTION: The purpose of this study was to evaluate the effects of dual-task gait testing in older adults with trans-tibial amputations. METHODS: Twenty-four people (15 men, mean age ±â€¯SD, 62.72 ±â€¯8.59) with trans-tibial amputation walked on an electronic walkway at i) self-selected comfortable pace and ii) self-selected comfortable pace while counting backwards by threes from a number randomly selected between 100 and 150. Cognitive performance, in the form of corrected response rate, was also evaluated as a single-task. RESULTS: The dual-task testing produced poorer performance in velocity (single-task = 58.15 ±â€¯23.16 cm/s, dual-task = 50.92 ±â€¯21.16 cm/s, p = 0.008), cadence (single-task = 76.65 ±â€¯15.84 steps/min, dual-task = 67.85 ±â€¯15.76 steps/min, p = 0.002) and stride time (single-task = 1094 ±â€¯458.28 ms, dual-task = 1241.44 ±â€¯513.73 ms, p = 0.005). Step length, stance time and single limb support time symmetry were also affected, such that less time was spent on the amputated limb during the dual-task testing. SIGNIFICANCE: Dual-task testing demonstrated interference resulting in a poor performance in both gait and cognitive performance in trans-tibial amputees. Further research is suggested to evaluate the change in cognition-mobility effects over time and the relationship of this value to future adverse events such as falls and successful outcomes such as community ambulation and reintegration.

Self-reported maximum walking distance in persons with MS may affect the EDSS.

BACKGROUND: In persons with MS (PwMS), the Expanded Disability Status Scale (EDSS) is used to monitor disability progression. Scores between 4.0 and 7.0 are determined by maximum walking distance. Self-estimation of this value is often employed in clinic settings. OBJECTIVE: To examine the accuracy with which PwMS estimate their walking distance, and observe subsequent changes to the EDSS. METHODS: This prospective cohort study recruited PwMS with previously recorded EDSS of 3.5-7.0. Participants estimated their maximum walking distance and then walked as far as they could along a pre-specified course. Each distance was converted to an EDSS score, the "estimated EDSS" and the "actual EDSS". Chi-Square analysis was used to compare EDSS scores. Logistic regression was used to determine predictors of inaccurate estimations. RESULTS: Of the 66 PwMS in this study, 43.9% had a difference in the actual EDSS compared to the estimated EDSS. Median estimated EDSS was 4.75 (range 3.0-7.0); after walking assessment, median actual EDSS was 5.0 (range 3.0-7.0), which represented a significant difference [X2 (df 64, N=66)=206.9; p<0.001]. Actual EDSS decreased in 9 PwMS (13.6%) and increased in 20 PwMS (30.3%). Logistic regression did not find any demographic/disease characteristic to be predictive of this discrepancy. CONCLUSION: Some PwMS do not accurately estimate maximum walking distance; only 56.1% of PwMS accurately estimated their actual EDSS.

Peer assessment in the objective structured clinical examination: A scoping review.

BACKGROUND: The objective structured clinical examination (OSCE), originally designed with experts assessing trainees' competence, is more frequently employed with an element of peer assessment and feedback. Although peer assessment in higher education has been studied, its role in OSCEs has not reviewed. AIMS: The aim of this study is to conduct a scoping review and explore the role of peer assessment and feedback in the OSCE. METHODS: Electronic database and hand searching yielded 507 articles. Twenty-one full records were screened, of which 13 were included in the review. Two independent reviewers completed each step of the review. RESULTS: Peer-based OSCEs are used to assess students' accuracy in assessing OSCE performance and to promote learning. Peer examiners (PE) tend to award better global ratings and variable checklist ratings compared to faculty and provide high-quality feedback. Participating in these OSCEs is perceived as beneficial for learning. CONCLUSIONS: Peer assessment and feedback can be used to gauge PE reliability and promote learning. Teachers using these OSCEs must use methodology which fits their purpose. Competency-based education calls for diversification of assessment practices and asks how assessment impacts learning; the peer-based OSCE responds to these demands and will become an important practice in health professions education.

Impact of Course Configuration on 6-Minute Walk Test Performance of People with Lower Extremity Amputations.

Purpose: The configuration of the 6-minute walk test (6MWT) may influence the distance walked and comparability of results among subjects and across programmes. The purpose of this study was to evaluate the relative and absolute test-retest reliability of two 6MWT configurations and to evaluate the agreement between these two configurations in users of lower extremity prosthetics. Methods: A cross-sectional design was used to analyze data from 25 subjects completing in-patient prosthetic rehabilitation (mean age 63.12 [SD 13.77] y; 72% male). Two configurations of the 6MWT were examined, and relative and absolute test-retest reliabilities were calculated. Bland-Altman plots were constructed to evaluate agreement between configurations. Results: The relative test-retest reliability was excellent for both Configuration 1 and Configuration 2: ICC 0.97, 95% CI: 0.93, 0.98, and ICC 0.97, 95% CI: 0.94, 0.99, respectively. Comparable values for absolute test-retest reliability were also found. The Bland-Altman plot demonstrated a difference of ±63.92 meters between configurations. Conclusions: The two 6MWT configurations had excellent relative and absolute test-retest reliability, but the results from each configuration do not agree sufficiently to make them interchangeable or directly comparable. This highlights the importance of explicitly indicating the test configuration for the 6MWT when reporting results.

Objectif : la configuration du test de marche de 6 minutes (TM6M) peut influencer la distance marchée et la comparabilité des résultats entre sujets et entre programmes. L'objectif de cette étude était d'évaluer la fiabilité relative et absolue test­retest de deux configurations de TM6M et d'évaluer la concordance de ces deux configurations chez des personnes portant une prothèse à un membre inférieur. Méthodologie : les chercheurs ont analysé les données de 25 sujets suivant une réadaptation prothétique à l'hôpital à l'aide d'une méthodologie transversale (âge moyen de 63,12 [ÉT 13,77] ans; 72 % d'hommes). Ils ont examiné les deux configurations du TM6M et calculé la fiabilité relative et absolue test­retest. Ils ont créé un graphique Bland­Altman pour évaluer la concordance entre les configurations. Résultats : la fiabilité relative test­retest était excellente pour les deux configurations. CIC 0,97; IC à 95 % (0,93; 0,98) et CIC 0,97; IC à 95 % (0,94; 0,99), respectivement. Ils ont aussi observé des valeurs comparables pour la fiabilité absolue test­retest. Le graphique Bland­Altman a révélé une différence de±63,92 m entre les deux configurations. Conclusions : les deux configurations du TM6M ont obtenu une excellente fiabilité relative et absolue test­retest. Cependant, les résultats de chaque configuration ne concordent pas suffisamment pour les rendre interchangeables ou directement comparables. Cette constatation fait ressortir l'importance d'indiquer explicitement la configuration du test pour le TM6M au moment de rendre compte des résultats.

Barriers to outcome measure administration and completion at discharge from inpatient rehabilitation of people with amputation.

We performed a retrospective chart review of consecutive patients discharged from an inpatient amputee rehabilitation program over a 2 yr period (January 2010-December 2011). Our objective was to determine barriers to the completion of a standardized maximum walk test (MWT) at discharge. Over the study period, there were 190 discharges. The sample had a mean age of 63.5 yr (standard deviation [SD] +/- 14.2 yr), was 71.6% male, and had a majority of transtibial amputation (67%). The average length of inpatient stay was 28.1 d (SD +/- 13.2 d). MWT including distance and time was completed in 149 (78%) of the discharges; the main factors limiting patient performance on this measure were cardiorespiratory fatigue (53%), lower-limb pain (24%), back pain (12%), and skin problems (6%). Among those patients who completed the MWT, in 31% no limiting factor was identified. Forty-one discharge MWTs were not completed as a result of nonambulatory status (34%), acute illness (17%), limb pain (7%), skin problems (12%), or other reasons. Knowing these limitations may direct care from a clinical standpoint and provides valuable data for research planning to further examine outcome measures in this population.

Use of calcitonin in recalcitrant phantom limb pain complicated by heterotopic ossification.

BACKGROUND: Phantom limb pain (PLP) is a common complication after amputation, affecting up to 80% of the amputee population. However, only 5% to 10% of amputees have severe PLP impacting daily function. The present report details the management of severe, treatment-resistant PLP in a 72-year-old man with a traumatic left transradial amputation and a comorbid complication of heterotopic ossification (HO). OBJECTIVE: To describe a case of PLP with HO and the possible role of calcitonin in the treatment of both conditions. METHODS: A systematic review of the literature regarding the management of PLP. RESULTS: Seventeen articles that directly addressed PLP were identified; 11 were randomized controlled trials. All involved small samples and follow-up ranged from 6 h to one year, with the majority limited to six weeks. DISCUSSION: In the present case, medication management was limited by side effects, lack of response and the patient's desire to avoid long-term medication. Investigations revealed HO, which was suspected to envelop the median nerve in the proximal forearm. After several unsuccessful medication trials, the literature was reviewed in search of common variables between HO formation and persistent PLP. Ultimately, the biochemical effects associated with nerve injury were identified to be a possible factor in both HO and PLP development. Calcitonin's proposed mechanisms of action may help to manage HO and PLP at multiple stages of disease development and maintenance. In the present case, a four-week trial of intranasal calcitonin was successful, with pain control lasting at least 18 months. CONCLUSION: The present case report provided a review of the current literature in PLP pharmacological management and the current understanding of the etiology of PLP and HO, as well as how the two may coexist. It also provided an opportunity to discuss the proposed mechanisms of action of calcitonin in the management of PLP and HO.

Anatomy of the proximal tibiofibular joint and interosseous membrane, and their contributions to joint kinematics in below-knee amputations.

A result of below-knee amputations (BKAs) is abnormal motion that occurs about the proximal tibiofibular joint (PTFJ). While it is known that joint morphology may play a role in joint kinematics, this is not well understood with respect to the PTFJ. Therefore, the purposes of this study were: (i) to characterize the anatomy of the PTFJ and statistically analyze the relationships within the joint; and (ii) to determine the relationships between the PTFJ characteristics and the degree of movement of the fibula in BKAs. The PTFJ was characterized in 40 embalmed specimens disarticulated at the knee, and amputated through the mid-tibia and fibula. Four metrics were measured: inclination angle (angle at which the fibula articulates with the tibia); tibial and fibular articular surface areas; articular surface concavity and shape. The specimens were mechanically tested by applying a load through the biceps femoris tendon, and the degree of motion about the tibiofibular joint was measured. Regression analyses were performed to determine the relationships between the different PTFJ characteristics and the magnitude of fibular abduction. Finally, Pearson correlation analyses were performed on inclination angle and surface area vs. fibular kinematics. The inclination angle measured on the fibula was significantly greater than that measured on the tibia. This difference may be attributed to differences in concavity of the tibial and fibular surfaces. Surface area measured on the tibia and fibula was not statistically different. The inclination angle was not statistically correlated to surface area. However, when correlating fibular kinematics in BKAs, inclination angle was positively correlated to the degree of fibular abduction, whereas surface area was negatively correlated. The characteristics of the PTFJ dictate the amount of fibular movement, specifically, fibular abduction in BKAs. Predicting BKA complications based on PTFJ characteristics can lead to recommendations in treatment.

Low vitamin B12 in patients on admission to an amputation rehabilitation unit: a retrospective study.

OBJECTIVE: The purpose of this study was to determine the prevalence of low vitamin B12 (VB12) in patients on admission to an amputation rehabilitation unit and identify specific populations at risk. METHODS: A retrospective chart review was performed for 127 participants comprising patients with major lower limb amputations admitted to a regional amputation rehabilitation program between January 1, 2011 and December 31, 2012. Electronic medical records were reviewed for demographic data, amputation data, medication history, serum VB12 levels, and other related blood work. A literature-based cutoff of VB12 <260 pmol/L was used as the criterion for low VB12. RESULTS: The prevalence of low VB12 was 59.8%. Patients aged ≥55 years were found to have an increased prevalence of low VB12 (P = .05). Serum VB12 levels were significantly lower among patients aged ≥55 years (P < .05) and among patients with a mean corpuscular volume >97 fL (P < .01). No other differences in prevalence were determined among different demographics, etiologies, or comorbidities. CONCLUSIONS: Patients with an amputation have a high prevalence of low VB12 levels compared with the general population. Low VB12 status may impact rehabilitation outcomes through anemia, cognitive decline, and neuropathy. No reliable indicators for which patients should be screened were found, and therefore, a universal approach to screening and treatment is needed.

In vitro biomechanical evaluation of fibular movement in below knee amputations.

BACKGROUND: In below knee amputations, the remaining fibula may be subjected to abnormal forces resulting in problematic tibia-fibular movement. The purpose of the current work was to examine the effect of amputation length and interosseous membrane integrity on fibular movement when subjected to unopposed biceps femoris muscle tension. METHODS: Forty embalmed cadaveric specimens were subjected to a below knee amputation with fibular lengths of 5cm and 10cm. A subset of specimens (n=20) was further modified by sectioning the interosseous membrane. The tibias were mounted in a material testing machine and the biceps femoris was sutured to the actuator. Position-controlled tensile cyclic loading was applied (initial displacement of 4mm for 100 cycles at 0.5Hz with increments of 2mm up to 20mm) to the biceps femoris. The kinematics of the fibula with respect to the tibia was analyzed for three degrees of freedom: abduction, flexion and rotation. FINDINGS: There was no interaction between below knee amputation length and interosseous membrane integrity on the degree of abduction, flexion, and rotation. However, below knee amputations with a sectioned interosseous membrane are abducted to a significantly greater degree than intact interosseous membrane below knee amputations. Furthermore, although embalmed specimens were tested here, embalming was consistent across specimens and it is unlikely that this confounded the findings. INTERPRETATION: Understanding the cause of fibular abduction in below knee amputation will lead to recommendations for preventive surgical and rehabilitative measures.

Comorbidities in amputation: a systematic review of hemiplegia and lower limb amputation.

PURPOSE: The purpose of this review of the scientific literature was to investigate the incidence and prevalence of hemiplegia with lower limb amputation, and to identify outcomes following the dual disability of hemiplegia and amputation. METHODS: Electronic searching of the literature identified major studies examining the effects of hemiplegia on rehabilitation following amputation. Data were extracted and levels of evidence assigned for each subtopic area. RESULTS: The summary conclusions are Level 4 evidence. The prevalence of amputation and hemiplegia is 8-18% and amputation and hemiplegia occur most often in the same leg. Once individuals with hemiplegia and lower limb amputation are selected for prosthetic rehabilitation, rate of successful functional ambulation is greater than 58%. In general there is a lower rate of prosthetic success and independence with hemiplegia than without. Predictive factors associated with success include less severe hemiplegia, laterality of hemiplegia (ipsilateral and right side), transtibial level of amputation and absence of impaired mental function. There is wide variation in length of hospital stay, but a specialty multidisciplinary team reduces length of stay. CONCLUSIONS: Patients with dual disability of hemiplegia and amputation generally benefit from a prosthetic rehabilitation program. Further study on predictive factors for outcome would be beneficial. IMPLICATIONS FOR REHABILITATION: • The prevalence of hemiplegia with lower limb amputation ranges from 8 to 18%, most frequently affecting the same leg. • The majority of patients attain successful functional levels of ambulation with prosthetic rehabilitation, although lower rates than nonhemiplegic patients. • Predictive factors associated with greater success include less severe hemiplegia, ipsilateral hemiplegia, transtibial level of amputation and absence of impaired mental function.