1.
Cleve Clin Q
; 49(4): 255-64, 1982.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7168915
Assuntos
Cromatina/ultraestrutura , Neurônios Motores/ultraestrutura , Organoides/ultraestrutura , Tétano/patologia , Vacúolos/ultraestrutura , Humanos , Hipóxia/patologia , Masculino , Pessoa de Meia-Idade , Mitocôndrias/ultraestrutura , Doenças Neuromusculares/patologia , Partículas Submitocôndricas/ultraestrutura , Toxina Tetânica/efeitos adversos
2.
Brain
; 103(4): 885-904, 1980 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7002260
RESUMO
Brains from three human cases of Creutzfeldt-Jakob disease and three monkey cases of transmitted Creutzfeldt-Jakob disease were examined. Spongiform change was present in all cases on both light and electron microscopic examination. Electron microscopic examination revealed membrane alterations within vacuoles in all cases. On SEM, both ulcerated and focally thickened membranes were apparent; TEM revealed splitting of unit membranes as well as focally thickened amorphous membranes. Small blisters with 70 to 150 nm particulates were seen on membranes in SEM. TEM revealed 10 nm electron-dense particles which might be either part of the infectious agent or a membrane alteration caused by it. The significance of these findings was discussed.