RESUMO
The authors examined change in cerebral metabolic function over time by using PET in HIV-infected individuals diagnosed with AIDS. Ten subjects with AIDS received [18F]2-fluoro-2-deoxy-D-glucose PET scans and completed a comprehensive neuropsychological battery. The scan and test battery were repeated after 6 months. Over time, the subjects showed increased relative basal ganglia metabolism as well as increased parietal lobe metabolism. There were no statistically significant changes in neuropsychological performance. These results suggest that PET may be more sensitive than traditional neuropsychological evaluation to subtle central nervous system changes in AIDS.
Assuntos
Complexo AIDS Demência/diagnóstico por imagem , Glicemia/metabolismo , Encéfalo/diagnóstico por imagem , Metabolismo Energético/fisiologia , Tomografia Computadorizada de Emissão , Complexo AIDS Demência/diagnóstico , Complexo AIDS Demência/fisiopatologia , Adulto , Gânglios da Base/diagnóstico por imagem , Gânglios da Base/fisiopatologia , Bissexualidade , Encéfalo/fisiopatologia , Mapeamento Encefálico , Desoxiglucose/análogos & derivados , Fluordesoxiglucose F18 , Seguimentos , Homossexualidade Masculina , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Lobo Parietal/diagnóstico por imagem , Lobo Parietal/fisiopatologiaRESUMO
Eighty-one clinically diagnosed (DSM-III) Hispanic and Anglo schizophrenic subjects were evaluated with a structured diagnostic interview, the National Institute of Mental Health Diagnostic Interview Schedule (NIMH-DIS), and a battery of rating instruments (Brief Psychiatric Rating Scale, Clinical Global Impressions, Global Assessment Scale, and Hopkins Symptom Checklist 90 [SCL-90]). The authors examined: a) consistency in reporting of symptoms across different instruments administered in different formats and b) the importance of ethnic background in consistency of responses to the different instruments. A subgroup of patients (23% of total) "denied" lifetime schizophrenic symptoms in the lay interviewer-administered structured interview ("DIS negative" schizophrenic subjects). The proportion of DIS negative subjects was very similar across the two ethnic groups. However, responses by DIS negative schizophrenic subjects to a self-rating instrument (SCL-90) were significantly different for Hispanic and Anglo subjects. A subgroup of Anglo subjects denied symptoms in the DIS, but volunteered them in the self-rating instrument. Responses of Hispanic subjects were consistent regardless of format.
