Indication criteria for monoclonal antibody treatment for COVID-19 in the era of vaccination: is an update needed?

This study describes a cohort of 223 patients who received anti-S protein monoclonal antibody (mAb) treatment for COVID-19 after having met the indication criteria set by the national guidelines in the Czech Republic at the time. The authors compare the vaccinated and unvaccinated subpopulations of this cohort. The results show that most of the patients (73.5%) already had significant circulating levels of anti-S antibodies detectable at the time of treatment. The authors confirm a positive correlation between number of vaccine doses and S-protein antibody levels. The data show, that vaccinated patients are overall less likely to be hospitalized than unvaccinated ones. The authors recommend a change in the national guidelines for mAb treatment in the Czech Republic.

[Listeriosis a review of current knowledge]. / Listerióza prehled soucasných znalostí.

The study includes a recent review of the epidemiology, pathogenesis and clinical picture of listeriosis and new data concerning its treatment.

[Listeriosis - four case reports]. / Listerióza - kazuistika ctyr prípadu.

The authors described four cases of listeria infection. The patients were hospitalized in the Department of Infectious Diseases of the Masaryk Hospital in Ustí nad Labem during the epidemic outbreak of this infection around the turn of 2006/2007. The disease in three of the four patients was manifested as purulent meningitis and in the remaining one as a sepsis. All of the patients were above the age of 55 years; moreover, two of them were assumed to be immunocompromised. In three of the patients, whose laboratory findings revealed purulent meningitis, direct microscopy of cerebrospinal fluid (CSF), specific latex agglutination test and PCR were negative. Final diagnosis was determined on the basis of the CSF and blood cultures reported 3-4 days after collection. None of the patients suffered from diarrhoea. In the epidemiological anamnesis, only two of them admitted consumption of food that could become source of infection. The patients were successfully treated with either ampicillin and chloramphenicol.