1.
Cesk Farm
; 41(7-8): 264-5, 1992 Oct.
Artigo
em Eslovaco
| MEDLINE
| ID: mdl-1362693
RESUMO
The present paper investigated histological changes in the myocardium in two potential beta-adrenolytic agents, 4-[3-isopropylamino-2-hydroxypropoxy]-3-[propoxymethyl]acetophenone and 4-[3-isopropylamino-hydroxypropoxy]-3-[pentyloxymethyl]acetophenon e after intravenous administration in doses of 8 mg/kg and 24 mg/kg. It results from the found data that in both agents in the doses used there are no necrotic changes in the myocardium and the values of the impairment range within the 1st degree of Zbinden's classification, comparable to the standard metipranolol.
Assuntos
Acetofenonas/toxicidade , Antagonistas Adrenérgicos beta/toxicidade , Miocárdio/patologia , Propanolaminas/toxicidade , Animais , Coração/efeitos dos fármacos , Masculino , Ratos , Ratos Wistar
2.
Pharmazie
; 40(1): 64, 1985 Jan.
Artigo
em Alemão
| MEDLINE
| ID: mdl-3991794