[The synthesis of linear trilactosamine].

Trilactosamine Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-sp, where sp = O(CH2)3NH2 is a spacer, was synthesized. The tetrasaccharide fragment Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta-sp was obtained by successive glycosylation using elongation by one monosaccharide residue at a time, and the tetrasaccharide was then transformed into a hexasaccharide with a disaccharide glycosyl donor. A 2,2,2-trichloroethoxycarbonyl group was used for the protection of the glucosamine amino group.