RESUMO
La isotretinoína fue aprobada para el tratamiento del acné desde 1982 y en la actualidad es usada para el tratamiento de un amplio número de alteraciones dermatológicas. Entre las recomendaciones de la American Academy of Dermatology Consensus Conference está no usar este tratamiento en mujeres embarazadas, sin embargo no se hace mención a los posibles riesgos en la salud sexual y reproductiva masculina, población en la cual también es comúnmente usado este medicamento para el tratamiento del acné.
Isotretinoin was tested for treatment of acne from 1982 and nowadays is used for treatment of a wide number of skin alterations. Among the recommendations of the American Academy of Dermatology Consensus Conference is included the non-use of this treatment in pregnant women, however, it is not mentioned the potential risks in sexual and reproductive men health, group in which is commonly used for treatment of acne.
RESUMO
OBJECTIVES: This is a descriptive prospective study of semen analysis in 113 men who were candidates for vasectomy as an option for fertility control after a recent event of fertility. METHODS: Each subject provided a semen sample for the analysis of volume, pH, spermatozoid concentration, mobility, and morphology. The results were compared with the reference values established by WHO. RESULTS: Different from what was expected, a great proportion of these fertile subjects, 54.9%, showed at least one altered parameter in comparison to minimal values established by WHO. Generally, median values for the whole group were normal: volume 2.4 ml, spermatozoid concentration measured in Makler and Neubauer chambers 89 and 91 millions/ml, respectively; sperm mobility (A + B) 56%; vitality 78%; and normal morphology 79%. CONCLUSIONS: In this group of fertile subjects we found a high probability to have altered semen parameters, which argues questions the real value and significance of sperm analysis in the diagnosis of a subfertile patient.
