RESUMO
Myasthenia gravis can present with rapid respiratory failure as the first manifestation of disease. In the Lambert-Eaton myasthenic syndrome (LEMS), such a manifestation has rarely been reported. We are reporting a patient who developed respiratory failure as the first manifestation of LEMS without associated carcinoma.
Assuntos
Síndrome Miastênica de Lambert-Eaton/complicações , Síndrome do Desconforto Respiratório/etiologia , Insuficiência Respiratória/etiologia , Idoso , Feminino , HumanosAssuntos
Cistos Aracnóideos/complicações , Síndrome do Nevo Basocelular/complicações , Adulto , Síndrome do Nevo Basocelular/cirurgia , Encéfalo/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Transtornos de Enxaqueca/diagnóstico , Transtornos de Enxaqueca/etiologia , Neoplasias Cutâneas/cirurgiaRESUMO
We report three patients with both spongiform encephalopathy and cerebellar amyloid plaques; one showed kuru-like plaques and was diagnosed as having Creutzfeldt-Jakob disease (CJD), and two had multicentric plaques and were diagnosed as having Gerstmann-Sträussler-Scheinker disease (GSSD). Evaluation of these cases and review of others previously reported suggests a clinicopathologic correlation between type of cerebellar plaque and neurologic clinical course. CJD patients who showed kuru-like plaques generally had disease with early onset (average age, 49.1 years) and long duration (average, 34 months), as compared with CJD patients without kuru-like plaques. GSSD patients usually had multicentric cerebellar plaques, and cases were usually familial, had early age of onset (average, 42.7 years), and were of long duration (average, 73 months). Myoclonus was infrequent in GSSD patients and pathologically spongiform change was minimal; spinal tract degeneration was common.
Assuntos
Amiloide , Encéfalo/patologia , Doenças Cerebelares/patologia , Síndrome de Creutzfeldt-Jakob/patologia , Doenças por Vírus Lento/patologia , Adulto , Idoso , Ataxia Cerebelar/patologia , Feminino , Humanos , Kuru/patologiaRESUMO
The renal, hepatic, or gastrosplenic arteries of eleven juvenile pigs were selectively injected intraarterially with 95% ethanol to evaluate its efficacy as an agent for use in permanent occlusion and infarction of the vascular bed supplied by the injected artery. A dose of 2.2 cc/5 kg (1 cc/5 lb) of 95% ethanol was injected over 30-45 sec. The animals were then killed at 1 to 91 days and all pigs demonstrated tissue infarction and vascular occlusion. Our results confirm that ethanol is an effective agent for the infarction of organs and that complications can result if catheter placement is not precise and normal tissue is inadvertently perfused.