Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Estimulantes do Sistema Nervoso Central/uso terapêutico , Clonidina/efeitos adversos , Dextroanfetamina/uso terapêutico , Simpatolíticos/efeitos adversos , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Estimulantes do Sistema Nervoso Central/administração & dosagem , Criança , Clonidina/administração & dosagem , Clonidina/uso terapêutico , Dextroanfetamina/administração & dosagem , Overdose de Drogas , Quimioterapia Combinada , Humanos , Masculino , Simpatolíticos/administração & dosagem , Simpatolíticos/uso terapêuticoRESUMO
The Wiskott-Aldrich Syndrome (WAS) is a rare X-linked immunohematological disorder characterized by eczema, profound thrombocytopenia, and progressive immunodeficiency. Severe hemorrhage, overwhelming sepsis, or lymphoreticular malignancy usually cause death in childhood. Recently, bone marrow transplantation (BMT) has been curative in some well-established cases, but there is no general agreement about the place of BMT in infants with WAS before the development of significant immunological abnormalities. We describe the successful use of early histocompatible BMT in a 10-month-old infant in whom WAS was diagnosed on the basis of eczema, thrombocytopenia, small platelets, and raised serum immunoglobulin A (Ig) and IgE, but before the development of immunodeficiency as evidenced clinically by recurrent infections, or immunologically by low serum IgM or consistently abnormal lymphocyte responses to mitogens. After an unstable period for several weeks posttransplantation when he developed marked hepatomegaly and severe interstitial pneumonitis, he made a good recovery. His eczema and thrombocytopenia resolved and he has shown no clinical or laboratory evidence of immunodeficiency. It is now over 2 years since his BMT. Because of the poor prognosis of WAS, where a histocompatible donor is available, BMT at the earliest opportunity, despite the inherent risks of such a procedure, may be the best option for an infant with WAS.
Assuntos
Transplante de Medula Óssea , Síndrome de Wiskott-Aldrich/cirurgia , Fatores Etários , Transplante de Medula Óssea/efeitos adversos , Seguimentos , Humanos , Hospedeiro Imunocomprometido , Imunoglobulinas/análise , Lactente , Contagem de Leucócitos , Masculino , Contagem de Plaquetas , Fibrose Pulmonar/etiologia , Síndrome de Wiskott-Aldrich/sangue , Síndrome de Wiskott-Aldrich/imunologiaRESUMO
We have carried out a randomised prospective controlled trial of the effect of tinted lenses on the reading ability of 24 non-asthmatic dyslexic children aged between nine and twelve years. Reading ability was assessed using the Neale Analysis of Reading. After one school term, there was no significant difference in the change in reading age between treatment and control groups. After two school terms (approximately six months), only 11 children (44%) were still wearing the glasses. Of 381 suitable subjects for entry into the study, 208 were excluded because of a diagnosis of asthma (to avoid effects of medication on cerebral function). As a result, we may have excluded subjects who would have responded favourably to tinted lenses.
