The ontogeny of aerobic and diving capacity in the skeletal muscles of Weddell seals.

Our objective was to determine the ontogenetic changes in the skeletal muscles of Weddell seals that transform a non-diving pup into an elite diving adult. Muscle biopsies were collected from pups, juveniles and adults and analyzed for changes in fiber type, mitochondrial density, myoglobin concentrations and aerobic, lipolytic and anaerobic enzyme activities. The fiber type results demonstrated a decrease in slow-twitch oxidative (Type I) fibers and a significant increase in fast-twitch oxidative (Type IIA) fibers as the animals mature. In addition, the volume density of mitochondria and the activity of lipolytic enzymes significantly decreased as the seals matured. To our knowledge, this is the first quantitative account describing a decrease in aerobic fibers shifting towards an increase in fast-twitch oxidative fibers with a significant decrease in mitochondrial density as animals mature. These differences in the muscle physiology of Weddell seals are potentially due to their three very distinct stages of life history: non-diving pup, novice diving juvenile, and elite deep diving adult. During the first few weeks of life, pups are a non-diving terrestrial mammal that must rely on lanugo (natal fur) for thermoregulation in the harsh conditions of Antarctica. The increased aerobic capacity of pups, associated with increased mitochondrial volumes, acts to provide additional thermogenesis. As these future elite divers mature, their skeletal muscles transform to a more sedentary state in order to maintain the low levels of aerobic metabolism associated with long-duration diving.

Rapid maxillary expansion with incisor intrusion: a study of vertical control.

This is a prospective study of 20 consecutively treated patients needing maxillary expansion and incisor intrusion. The patients were treated with a bonded maxillary expansion appliance, intrusion of the incisors with either a one-piece or three-piece base arch and anchorage augmented by the use of vertical-pull chincup therapy. Because rapid palatal expansion and intrusion of maxillary incisors both produce extrusion of posterior teeth, this study was undertaken to determine if a combination of controlled forces could prevent undesirable increases in vertical dimension. The maxillae were widened approximately 8 mm, the incisors were intruded 3 mm, the maxillary molars stayed the same or were intruded slightly, and the mandibular plane angle stayed essentially the same. In addition, A-point was retracted slightly and the occlusal plane was rotated in a counter-clockwise direction.

Celebrities and deceptive ads: Medigap sellers mislead many elderly.

Many elderly, misled by celebrity and door-to-door sales pitches, are buying unneeded medigap insurance policies. With federal regulations unlikely, it is up to states to stop abuses.

Vertical control in fully-banded orthodontic treatment.

A review of clinical considerations in the control of vertical dimension, with a statistical evaluation of 79 cases treated with a vertical-pull chincup before and during fixed-appliance therapy.