RESUMO
Cubebin, a dibenzylbutyrolactone lignan isolated from the crude hexane extract of the leaves of Zanthoxyllum naranjillo, showed a significant anti-inflammatory activity by using the paw edema induced by carrageenin in rats, but did not provide a significant reduction in the cell migration for the acute carrageenin-induced inflammatory reaction in the peritoneal cavity of rats. Neither was it effective in reducing the edema induced by dextran nor the edema induced by histamine. It partially reduced the edema induced by serotonin. Moreover, it significantly reduced the edema induced by prostaglandin PGE2 and the number of writhings induced by both acetic acid and PGI2 in mice. Therefore, it may be suggested that the mechanism of action of cubebin is similar to that observed for most of the non-steroidal drugs.
Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Lignanas/farmacologia , Rosales/química , Animais , Masculino , Camundongos , Folhas de Planta/química , Ratos , Ratos WistarRESUMO
Acute phase proteins play an important role in clinical laboratory diagnosis, especially after recent development of quantitation methods. Turbidimetry and nephelometry, spectrophotometric procedures based on the quantitation of scattered and reflected light, permit laboratory analyses of higher precision, sensitivity and specificity compared to previously employed methods.
Assuntos
Proteínas de Fase Aguda/análise , Técnicas de Laboratório Clínico , Biomarcadores , HumanosAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Neoplasias da Mama/tratamento farmacológico , Hemostasia/efeitos dos fármacos , Coagulação Sanguínea/efeitos dos fármacos , Ciclofosfamida/efeitos adversos , Fluoruracila/efeitos adversos , Humanos , Metotrexato/efeitos adversosRESUMO
The authors showed that the colorimetric methods used to effect aminoacidopathies screening are inadequate and unspecific. The thin layer chromatography was chosen to effect such screening and the authors showed the incidence in newborns of some aminoacid metabolism abnormalities.