Assuntos
Adenocarcinoma/complicações , Adenocarcinoma/genética , Síndrome Hipereosinofílica/complicações , Síndrome Hipereosinofílica/genética , Proteínas de Fusão Oncogênica/genética , Neoplasias Pancreáticas/complicações , Neoplasias Pancreáticas/genética , Idoso , Idoso de 80 Anos ou mais , Cromossomos Humanos Par 12/genética , Cromossomos Humanos Par 15/genética , Doença Crônica , Feminino , Humanos , Síndrome Hipereosinofílica/sangue , Hibridização in Situ Fluorescente , Translocação GenéticaRESUMO
Clinical charts from 63 consecutive highly immunocompromised haematologic patients presenting with pulmonary nodular lesions on CT scan, classified as either probable or possible invasive fungal disease (IFD) according to the revised EORTC/MSG classification, were retrospectively studied. Histopathological analysis of lung tissues, available for 23 patients, demonstrated proven IFD in 17 cases (14 invasive aspergillosis and 3 invasive zygomycosis), diffuse alveolar damage in one and organising pneumonia (OP) in five cases. In the OP cases, three of which have been defined as probable IFD according to EORTC/MSG classification, extensive immunohistochemical, molecular and immunological analyses for fungi were negative. Our case descriptions extend the notion that OP may be encountered as a distinct histopathological entity in pulmonary nodular lesions in patients with leukaemia with probable/possible IFD.
