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Fitoterapia ; 123: 73-78, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28941743

RESUMO

Three new iridoids, valejatanins A-C (1-3), and one new natrual iridoid (4), together with four known sesquiterpenoids (5-8), were isolated from the roots of Valeriana jatamansi Jones. Compounds 3 and 4 are C(4)-epimers. Their structures were elucidated by extensive spectroscopic analysis (IR, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. The absolute configuration of 5 was determined for the first time by single-crystal X-ray diffraction analysis with Cu-Kα irradiation. The cytotoxic activities of all compounds were evaluated against HT29, K562 and B16 cancer cell lines in vitro by MTT assay. Valejatanin A (1) showed noteworthy cytotoxic activities with IC50 values of 22.17, 15.26, 3.53µg/mL against three cancer cell lines. The antibacterial activities of all compounds against bacteria were tested in vitro. Compound 6 exhibited antibacterial activities against Staphylococcus aureus and Pseudomonas aeruginosa.


Assuntos
Antibacterianos/química , Iridoides/química , Sesquiterpenos/química , Valeriana/química , Animais , Antibacterianos/isolamento & purificação , Linhagem Celular Tumoral , Humanos , Iridoides/isolamento & purificação , Camundongos , Testes de Sensibilidade Microbiana , Estrutura Molecular , Raízes de Plantas/química , Pseudomonas aeruginosa/efeitos dos fármacos , Sesquiterpenos/isolamento & purificação , Staphylococcus aureus/efeitos dos fármacos
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