Lexical repertoire of 24 and 30-month-old children speaking Brazilian portuguese: preliminary results. / Repertório lexical de crianças de 24 e 30 meses falantes do português brasileiro: resultados preliminares.

PURPOSE: To check the lexical repertoire of Brazilian Portuguese-speaking children at 24 and 30 months of age and the association between the number of words spoken and the following variables: socioeconomic status, parents' education, presence of siblings in the family, whether or not they attend school, and excessive use of tablets and cell phones. METHODS: 30 parents of children aged 24 months living in the state of São Paulo participated in the study. Using videoconferencing platforms, they underwent a speech-language pathology anamnesis, an interview with social services, and then they completed the "MacArthur Communicative Development Inventory - First Words and Gestures" as soon as their children were 24 and 30 months old. Quantitative and qualitative inferential inductive statistics were applied. RESULTS: the median number of words produced was 283 at 24 months and 401 at 30 months, indicating an increase of around 118 words after six months. The child attending a school environment had a significant relationship with increased vocabulary. CONCLUSION: The study reinforces the fact that vocabulary grows with age and corroborates the fact that children aged 24 months already have a repertoire greater than 50 words. Those who attend school every day produce at least 70 more words than those who do not.

OBJETIVO: Verificar o repertório lexical de crianças falantes do português brasileiro aos 24 e 30 meses e a associação entre a quantidade de palavras faladas e as variáveis: nível socioeconômico, escolaridade dos pais, presença de irmãos no convívio familiar, frequentar ou não escola e uso exacerbado de tablets e celulares pelas crianças. MÉTODO: 30 pais de crianças com 24 meses, residentes no estado de São Paulo participaram do estudo. Por meio de plataformas de videoconferência eles foram submetidos à anamnese fonoaudiológica, entrevista com o serviço social e preencheram o "Inventário MacArthur de Desenvolvimento Comunicativo - Primeiras Palavras e Gestos", quando seus filhos tinham 24 e 30 meses. Foi aplicada estatística indutiva inferencial, quantitativa e qualitativa. RESULTADOS: A mediana das palavras emitidas foi de 283 aos 24 meses e 401 aos 30 meses, indicando aumento em torno de 118 palavras após seis meses. A criança estar frequentando ambiente escolar apresentou relação significativa com o aumento do vocabulário. CONCLUSÃO: O estudo reforça o crescimento do vocabulário conforme o avanço da idade e corrobora o fato de as crianças com 24 meses já possuírem um repertório maior que 50 palavras. Aqueles que frequentam escola diariamente produzem pelo menos 70 palavras a mais dos que não frequentam.

Repertório lexical de crianças de 24 e 30 meses falantes do português brasileiro: resultados preliminares / Lexical repertoire of 24 and 30-month-old children speaking Brazilian portuguese: preliminary results

RESUMO Objetivo Verificar o repertório lexical de crianças falantes do português brasileiro aos 24 e 30 meses e a associação entre a quantidade de palavras faladas e as variáveis: nível socioeconômico, escolaridade dos pais, presença de irmãos no convívio familiar, frequentar ou não escola e uso exacerbado de tablets e celulares pelas crianças. Método 30 pais de crianças com 24 meses, residentes no estado de São Paulo participaram do estudo. Por meio de plataformas de videoconferência eles foram submetidos à anamnese fonoaudiológica, entrevista com o serviço social e preencheram o "Inventário MacArthur de Desenvolvimento Comunicativo - Primeiras Palavras e Gestos", quando seus filhos tinham 24 e 30 meses. Foi aplicada estatística indutiva inferencial, quantitativa e qualitativa. Resultados A mediana das palavras emitidas foi de 283 aos 24 meses e 401 aos 30 meses, indicando aumento em torno de 118 palavras após seis meses. A criança estar frequentando ambiente escolar apresentou relação significativa com o aumento do vocabulário. Conclusão O estudo reforça o crescimento do vocabulário conforme o avanço da idade e corrobora o fato de as crianças com 24 meses já possuírem um repertório maior que 50 palavras. Aqueles que frequentam escola diariamente produzem pelo menos 70 palavras a mais dos que não frequentam.

ABSTRACT Purpose To check the lexical repertoire of Brazilian Portuguese-speaking children at 24 and 30 months of age and the association between the number of words spoken and the following variables: socioeconomic status, parents' education, presence of siblings in the family, whether or not they attend school, and excessive use of tablets and cell phones. Methods 30 parents of children aged 24 months living in the state of São Paulo participated in the study. Using videoconferencing platforms, they underwent a speech-language pathology anamnesis, an interview with social services, and then they completed the "MacArthur Communicative Development Inventory - First Words and Gestures" as soon as their children were 24 and 30 months old. Quantitative and qualitative inferential inductive statistics were applied. Results the median number of words produced was 283 at 24 months and 401 at 30 months, indicating an increase of around 118 words after six months. The child attending a school environment had a significant relationship with increased vocabulary. Conclusion The study reinforces the fact that vocabulary grows with age and corroborates the fact that children aged 24 months already have a repertoire greater than 50 words. Those who attend school every day produce at least 70 more words than those who do not.

Ejercicios motores orofaciales no verbales: uso y conocimiento de los fonoaudiólogos que trabajan con personas con trastornos de los sonidos del habla / Nonspeech oral motor exercises: use and knowledge of speech-language pathologists working with people with speech sound disorders

Estudios realizados en diferentes países (por ejemplo, Australia, Canadá, India, República de Irlanda, EE.UU., Reino Unido) han demostrado que los fonoaudiólogos utilizan ejercicios motores orofaciales no verbales (EMONV) para tratar los trastornos de los sonidos del habla (TSH), atrayendo atención hacia el sustancial debate que existe respecto a la eficacia clínica de estos ejercicios. En este contexto, el presente estudio tuvo como objetivo investigar y caracterizar el uso de los EMONV por parte de fonoaudiólogos portugueses que realizan intervenciones en TSH y evaluar el conocimiento que lo respalda. Para ello, se invitó a profesionales de la fonoaudiología que trabajan con niños con TSH a completar un cuestionario basado en Thomas y Kaipa (2015). Un total de 184 participantes respondió a la encuesta; 93,5% informó contar con conocimientos sobre los EMONV, 78.5% utiliza EMONV para el tratamiento de TSH y 80,2% los considera efectivos en el tratamiento del TSH (89% indicó que adquirió su conocimiento sobre EMONV a través de cursos de pregrado y posgrado; 98,5% informó que utiliza los EMONV para mejorar las funciones motoras de los órganos fonoarticulatorios). Este estudio ofrece una descripción general del uso de los EMONV por parte de fonoaudiólogos portugueses en la intervención en niños con TSH. Muchos de los participantes en este estudio informaron que utilizan EMONV en el tratamiento de TSH, independientemente de la falta de evidencia para respaldar su uso en este contexto. Estos hallazgos demuestran que el porcentaje de fonoaudiólogos en Portugal que utilizan EMONV es similar al encontrado en los EE.UU., Reino Unido, Canadá e India, pero diferente del porcentaje en Australia e Irlanda.

Previous studies, conducted in different countries (e.g. Australia, Canada, India, Republic of Ireland, USA, UK), have shown that speech-language pathologists (SLPs) use nonspeech oral motor exercises (NSOMEs) to treat speech sound disorders (SSDs), bringing attention to the substantial debate regarding the clinical effectiveness of NSOMEs. The aim of the present study was to investigate and characterize the use of NSOMEs by Portuguese SLPs in the intervention of SSDs, and to analyze the evidence that supports it. To do so, SLPs who provide therapy to children with SSDs were invited to complete an online questionnaire, based on a previous survey conducted in India by Thomas and Kaipa (2015). A total of 184 participants responded to the survey; 93.5% reported knowing about NSOMEs, 78.5% used NSOMEs in their intervention for SSDs, and 80.2% considered them effective in treating SSDs (89% indicated that their knowledge about NSOMEs was acquired through graduate and post-graduate courses; 98.5% reported that theyused NSOMEs to improve the motor function of the articulators). This study offers an overview of Portuguese speech-language pathologists' reported use of NSOMEs as part of the intervention of speech sound disorders in children. Many of the participants in this study reported that they did use NSOMEs in SSD treatments, regardless of the lack of evidence to support their use in this context. Furthermore, the results show that the percentage of SLPs in Portugal using NSOMEs is similar to those found in the USA, UK, Canada, and India, but different from those in Australia and Ireland.

Theory of mind in Portuguese school children: An exploratory study / Teoría de la mente en niños escolares portugueses: un estudio exploratorio

Introduction and objectives: Theory of mind (ToM) has been studied as well as children's mental states in relation to their everyday behaviour and is indispensable for skilled communication. Considering the importance of measuring ToM in school children, the aim of this exploratory investigation was to apply a preliminary Portuguese version of the ToM Picture Stories Task in a sample of school children aged from 6 to 8 years and to analyze the impact of individual differences (e.g. gender, parent's age, educational level, number of siblings) on task performance. Purpose: This article analyses ToM performance in a sample of 103 Portuguese school children in a public school. Method: Two stories of the ToM Pictures Sequencing Task were used to assess ToM competence in a sample of 103 participants (54 females and 49 males) aged from 6 to 8 years. Individual differences (e.g., gender, number of siblings, parents educational levels and age) were also considered. Results: The results showed good performances in story 1, but not as good in story 2. Positive correlations were found between age and year of schooling and performance in ToM tasks. Conclusion: Future research is needed regarding the influence of cognitive and linguistic skills in high-order ToM skills in school children.(AU)

Introducción y objetivos: La teoría de la mente (TM) ha sido estudiada como los estados mentales de los niños en relación con su comportamiento cotidiano, y es indispensable para la comunicación. Teniendo en cuenta la importancia de medir la TM en niños en edad escolar, el objetivo de esta investigación exploratoria fue aplicar una versión preliminar portuguesa de la tarea TM Picture Stories Task en una muestra de niños en edad escolar de 6 a 8 años y analizar el impacto de las diferencias individuales (p. ej., género, edad de los padres, nivel educativo, número de hermanos) en el desempeño de la tarea. Objetivo: El objetivo del trabajo fue determinar las habilidades de la TM en 103 niños portugueses. Metodología: Participaron 103 participantes (54 mujeres y 49 varones) con edades comprendidas entre los 6 y los 8 años. Todos fueron evaluados con dos pruebas de TM «Theory of Mind Pictures Sequencing Task». Resultados: Los resultados mostraron un buen desempeño en la historia 1, pero no tan bueno en la historia 2. Se encontraron correlaciones positivas entre la edad y el año de escolarización y el desempeño en tareas de la TM. Conclusiones: Futura investigación es necesaria en relación con la TM en la influencia de las habilidades cognitivas y lingüísticas de los niños.(AU)

Effects of the Narrative Intervention Program for Preschool Portuguese Children.

OBJECTIVE: This article analyzes the contribution of a narrative intervention program in linguistic performance (measured by the percentage of correct consonants [PCC], mean length of utterance [MLU], and auditory memory [AM]) of children. PATIENTS AND METHODS: A group of 14 children with primary language impairments participated in this study. The children were divided into two groups (seven children in each): the narrative intervention group (experimental group) and the control group. All children were treated by the same speech-language therapist. The narrative intervention program consisted of eight weekly group sessions. Outcome measures of PCC, MLU, and AM (of pseudowords, words, sentences, and orders) were taken before and after intervention. A qualitative assessment of the intervention effects from the perspective of the children's parents was also included. RESULTS: The results suggest improvements in PCC and MLU but no support for intervention effectiveness on these measures. In AM, the results indicate a significant intervention effect on words and orders. Parents reported intervention to be favorable/very favorable. CONCLUSION: The narrative intervention program was effective in enhancing children's AM. However, further investigation is required to provide clinical evidence for speech and language therapists to employ this program for children with primary language impairments.

Assessment of discomfort in patients with cognitive failure in palliative care.

OBJECTIVE: When cognitive impairment precludes patients' report of symptoms, it becomes necessary to use other means. The purpose of our study was to evaluate the validity of the method currently in use on our service. METHOD: Two members of the team simultaneously assessed the patient and independently recorded whether the patient showed signs of discomfort, and a third questioned patients with cognitive failure who maintained some ability to respond if something was bothering them. RESULTS: Some 200 assessments were made of 116 patients. The kappa coefficient of agreement was 0.615. The sensitivity was 17% and specificity 99%. The positive predictive value was 88%, and the negative predictive value was 73%. SIGNIFICANCE OF RESULTS: Due to the low sensitivity of this method, it cannot be recommended as a screening tool.

Evolution of costs of cancer drugs in a Portuguese hospital.

AIM: To analyze the costs of cancer drugs administered in a Portuguese Hospital compared with the Karolinska Institute study. METHODS: To evaluate spending on cancer drugs, we retrospectively analyzed data on the overall costs of cancer drugs, obtained at the Department of Medical Oncology of the Centro Hospitalar de Entre Douro e Vouga, between 2004 and 2010. In this comparative study we selected only drugs belonging to the following groups: chemotherapy, targeted therapy, immunotherapy and endocrine therapy. The selected drugs were further grouped according to their market placement year: ≤ 1998, 1999 to 2002, 2003 to 2005, and 2006 to 2010. Drugs used as supportive therapy and bisphosphonates were excluded. RESULTS: The overall costs of cancer drugs increased gradually between 2004 and 2008 (from €1911947 to €3666284), with an increase in the number of patients treated during this period. The expenditure decreased in 2009 (€3438155) and increased again in 2010 (€3673116), but the costs increment was not the same as in previous years. Chemotherapy and targeted therapy were responsible for most of the expenditure. Drugs placed on the national market before 1999 accounted for more than 50% of the expenditure up to 2007. From 2008, these drugs represented less than 50% of the total expenditure. Cancer drugs placed between 1999 and 2002 accounted for 25%-35% of the costs in all the years studied, while drugs placed between 2003 and 2005 accounted for less than 30%. Drugs placed between 2006 and 2010 were responsible for less than 10% of the expenditure. CONCLUSION: In this study, older drugs were responsible for most of the expenditure up to 2007, which is in agreement with the Karolinska study.

Bacillary prostatitis after intravesical immunotherapy: a rare adverse effect.

Nowadays, the most efficient form of intravesical immunotherapy for superficial transitional cell carcinoma of the urinary bladder is the instillation of bacillus Calmette-Guérin (BCG), proceeding from an attenuated strain of Mycobacterium bovis. In up to 40% of cases, its instillation is associated with significantly elevated prostate-specific antigen (PSA) levels. In these cases, prostate biopsy should be withheld for 3 months and PSA should be monitored. Bacillary prostatitis is a rare occurrence in patients treated with intravesical BCG immunotherapy. Although symptomatic bacillary prostatitis is even rarer, it is the worst type of this condition. The aims of this study are to report a case of bacillary prostatitis as a rare adverse effect of intravesical BCG immunotherapy and to make a theoretical review about how to manage this complication. A 58-year-old man, former smoker, underwent a transurethral resection of the bladder in February 2004 because of a papillary transitional cell carcinoma of the bladder (pT1G2N0M0). After surgery, BCG instillation therapy was given in a total of 15 instillations, the last one in March 2007. In the last 3 months of therapy, until May 2007, a progressive increase in his PSA level was registered, and he underwent a prostate biopsy revealing granulomatous prostatitis of bacillary etiology. The semen culture was positive for M. bovis. After 3 months of a two-drug (isoniazid and rifampin) antituberculous regimen, the semen culture became negative and the PSA level decreased. The early identification of intravesical BCG immunotherapy complications allows their effective treatment. However, when a histological diagnosis of asymptomatic granulomatous prostatitis is made, the execution and type of treatment are controversial.

Metastatic renal cell carcinoma: the importance of immunohistochemistry in differential diagnosis.

INTRODUCTION: Clear cell carcinoma accounts for 75% of all types of renal neoplasms. Approximately one third presents with metastatic disease at diagnosis. Immunohistochemical studies play a significant diagnostic role. CASE REPORT: We report the case of a 48-year-old heavy smoker who presented with productive cough and progressive dyspnea. The study revealed a renal mass and lung alterations compatible with primary tumor of the lung. The patient underwent a right complete nephrectomy. The anatomopathological exam showed clear cell renal carcinoma (pT1bN0Mx). After transthoracic needle aspiration biopsy, the clinical diagnosis was stage IV adenocarcinoma of the lung. Initially, the patient received one cycle of chemotherapy (cisplatin/pemetrexed). Two weeks later, the immunohistochemistry tests revealed a secondary lesion with probable renal origin. Chemotherapy was stopped and the patient was started on sunitinib treatment. After two cycles the disease progressed. A second-line treatment with everolimus was proposed; however, the patient died 2 weeks later due to terminal respiratory insufficiency. DISCUSSION: Clear cell renal cell carcinoma remains one of the great mimickers in pathology. Immunohistochemistry is a valuable tool in the differential diagnosis of lung carcinomas. With the help of thyroid transcription factor 1, it is possible to distinguish a primary lung tumor from a metastasis with a reasonable degree of certainty. The present case report illustrates the challenge of making a definitive and adequate diagnosis. The immunohistochemistry added information that changed the whole treatment strategy. For the best treatment approach, it is fundamental that clinicians await all possible test results, before establishing a treatment plan.