Assuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Toxidermias/diagnóstico , Exantema/diagnóstico , Piridinas/efeitos adversos , Sulfonas/efeitos adversos , Artralgia/tratamento farmacológico , Artralgia/patologia , Toxidermias/etiologia , Toxidermias/imunologia , Toxidermias/patologia , Etoricoxib , Exantema/induzido quimicamente , Exantema/imunologia , Exantema/patologia , Feminino , Humanos , Pessoa de Meia-Idade , Osteoartrite/tratamento farmacológico , Osteoartrite/patologia , Testes do EmplastroRESUMO
No disponible
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Exantema/complicações , Exantema/imunologia , Axila/lesões , Axila/fisiopatologia , Ibuprofeno/uso terapêutico , Hipersensibilidade a Drogas/complicações , Hipersensibilidade a Drogas/tratamento farmacológico , Hipersensibilidade a Drogas/imunologia , Aspartato Aminotransferases/uso terapêutico , Alanina Transaminase/uso terapêutico , Metilprednisolona/uso terapêutico , Anti-Inflamatórios não Esteroides/uso terapêutico , Hipersensibilidade/complicaçõesRESUMO
No disponible
Assuntos
Humanos , Rinite , Conferências de Consenso como Assunto , Rinite/diagnóstico , Rinite/terapiaRESUMO
Chronic urticaria is a changeable disorder with an unknown length of duration. Thus, an objective method which could differentiate affected individuals from healthy individuals and with predictive information about when treatment might be diminished or stopped would be desirable. Therefore, we have tried to achieve this by means of Multitest, a device rendering good skin reaction reproduction and reagents such as 48/80 Compound (a nonspecific mast cell degranulator) and histamine. These substances were applied on 1 to 10(3) Mol concentrations for histamine and 10 to 10(3) mg/ml as the degranulating agent. Sixteen patients and 10 controls were submitted to this test, variables such as drugs modifying wheals, time of the day, age range and skin area were controlled. In both groups a clear dose-response relationship was demonstrated by either reagent. However, an excessive individual variability appeared in each sample and significant differences could not be shown so much for sensitivity or for reactivity (responses by the lowest and the highest concentrations, respectively). We conclude that the lack of differences observed on cutaneous mast cell "releasability" and skin vessels response to histamine in chronic urticaria patients could be due to a rather outstanding role of other cells and its mediators, in mechanisms of that chronic disease.
Assuntos
Histamina/imunologia , Pele/imunologia , Urticária/imunologia , p-Metoxi-N-metilfenetilamina/imunologia , Adulto , Doença Crônica , Relação Dose-Resposta Imunológica , Feminino , Humanos , Masculino , Testes Cutâneos , Urticária/diagnósticoRESUMO
The authors report the first description of occupational asthma induced by sensitisation to danta or kotibe wood in an atopic, smoking, cabinet maker presenting with non-specific bronchial hyper-reactivity. The asthma used to appear several hours after finishing work and was exclusively on those days when he was handling danta wood. After exclusion of the offending allergen for several weeks a delayed asthmatic reaction was seen seven hours after a provocation test with the incriminated wood dust. The bronchial reaction was accompanied by cutaneous symptoms also. An immediate positive cutaneous reaction to the wood dust extract was seen and the cutaneous sensitivity could be passively transferred. These results, as well as the efficacy of treatment with disodium cromoglycate, suggest that an IgE mechanism is involved in the pathogenesis of this occupational asthma.
