[Co-infection of malaria and COVID-19 in patients admitted to the COVID Infectious Disease Department of the Libreville University Hospital Center]. / Co-infection paludisme et COVID-19 chez les patients admis au service d'infectiologie COVID du Centre Hospitalier Universitaire de Libreville.

The purpose of this study was to report the cases of co-infection of malaria and COVID-19, after systematic search for plasmodium in patients treated in the COVID Infectious Disease Department (SiCOV) of the Libreville University Hospital (LUH). We conducted a prospective, observational study in the LUH SiCOV from April to July 2020. Patients of both sexes, aged over 18 years, with positive Polymerase Chain Reaction (PCR) test for SARS-CoV-2 with thick blood smear result available, were included. For each patient, demographics (age, gender, weight, height), history and clinical and biological examination results were reported in the Excel file. Of a total of 253 patients who met the inclusion criteria, 8 had malaria associated with positive SARS-CoV-2 PCR. These were women (3) and men (5), with an average age of 36.9 years (25- 53 years). The mode of transmission was unknown in 7/8. All patients were febrile, 6/8 had headaches and 5/8 had respiratory discomfort. Less than half of patients had otolaryngeal (anosmia, ageusia) or digestive (diarrhea) manifestations. One patient with severe form died on day 5 of hospitalization. Clinical similarities between malaria and COVID-19 can lead to confusion in malaria endemic areas. The co-infection of malaria and COVID-19 did not result in severe clinical forms.

Detention provisoire des jeunes femmes accusees d'avortement clandestin ou d'infanticide au Senegal

Introduction: L'activite sexuelle chez les jeunes les expose a un accroissement du risque de contracter des grossesses non desirees. Le recours a l'avortement clandestin avec son corollaire de complications peut entrainer le deces de la jeune femme. Avortement et infanticide sont interdits et sanctionnes par la loi senegalaise. Comment ces jeunes femmes vivent-elles leur detention ? Existe-il des alternatives a la detention pour eviter leur desocialisation ? Methodes: Cette etude retrospective portait sur la maison d'arret des femmes de Dakar situee a Liberte 6; un quartier deDakar. Nous avons procede a des entretiens avec des femmes detenues a la maison d'arret des femmes de Dakar et suspectees d'infanticide ou d'avortement clandestin. Resultats: Les femmes de notre echantillon ont une moyenne d'age inferieure a 25 ans avec parmi elles une fille mineure de 16 ans. Nous avons trouve 18;51 de femmes suspectees d'infanticide ou d'avortement. Dans notre etude 50 des femmes sont originaires de la peripherie et de la banlieue de Dakar et presque 44 proviennent des autres regions du pays. La duree moyenne de detention provisoire est de neuf mois. Conclusion: Malgre leur qualification distincte dans le code penal : l'infanticide est un crime et l'avortement un delit; les femmes suspectees d'avoir commis ces actes sont soumises a de longues detentions preventives

[HBs Ag and antibodies to hepatitis C virus in complicated chronic liver disease in Gabon. A case control study]. / Antigène HBs et anticorps anti-VHC dans les hépatopathies chroniques compliquées au Gabon.

BACKGROUND AND OBJECTIVE: The prevalence of HBs Ag and anti-HCV antibodies are high in the general population in Gabon. The aim of this study was to perform a case control study to determine the role of hepatitis B and C viruses in decompensated cirrhosis and hepatocellular carcinoma. METHODS: Between October 1990 and June 1998, HBs Ag and anti-HCV antibodies were investigated in 1 204 newly hospitalized patients. Sixty-seven had decompensated cirrhosis, 38 had hepatocellular carcinoma and six an association of both diseases. Prevalences were compared with those in a group of 527 sex and age matched controls from the same cohort. RESULTS: HBs Ag prevalence among cases was 35.1% (decompensated cirrhosis: 34.2%; hepatocellular carcinoma: 40.5%) and 12.5% among controls. Anti-HCV were detected in 32.4% of cases (decompensated cirrhosis: 34.2%; hepatocellular carcinoma: 28.6%) and in 20.1% of controls. Complicated chronic liver disease was linked to HBs Ag (OR=11.3; IC: 4.8-26.7; cirrhosis: OR=18; IC: 5.3-61.5; hepatocellular carcinoma: OR=8.3; IC: 2.5-27.8) in patients from 15 to 34 years old. Above 45 years, complicated chronic liver disease was linked to anti-HCV antibodies (OR=2.9; IC: 1.6-5.3; cirrhosis: OR=2.8; IC: 1.4-5.8; hepatocellular carcinoma: OR=3.2; IC: 1.1-9.5). CONCLUSION: Both Hepatitis B and C viruses are linked to complicated chronic liver disease in Gabon in an age-dependent manner.